Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan

Abstract

BackgroundStudies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may improve our understanding of individual differences in sensitivity or resistance to certain drugs, thereby helping to avoid adverse drug reactions (ADRs) in patients and improve the quality of therapies. Here, we aimed to analyse single nucleotide polymorphisms (SNPs) involved in the ADME of multiple drugs in Kazakhs from Kazakhstan.ResultsA total of 158 SNPs involved in the ADME of various drugs were studied. We analysed 320 Kazakh DNA samples using OpenArray genotyping. Of the 158 SNPs, 75 were not found in heterozygous or homozygous variants. Comparative analysis among Kazakhs and world populations showed a fairly high percentage of population differentiation.ConclusionThese results provide further information for pharmacogenetic databases and may contribute to the development of personalized approaches and safer therapies for the Kazakh population. Moreover, these data provide insights into the different racial groups that may have contributed to the Kazakh population.Electronic supplementary materialThe online version of this article (doi:10.1186/s12863-016-0329-x) contains supplementary material, which is available to authorized users.

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Genetic Association of CYP1B1 4326 C>G Polymorphism with Disease-Free Survival in TNBC Patients Undergoing TAC Chemotherapy Regimen

“…Genetic variations such as single nucleotide polymorphisms (SNPs) have been widely studied as potential biomarkers in predicting disease recurrence and treatment outcomes. SNPs in genes encoding drug metabolizing enzyme such as cytochrome (P450) may activate (or inactivate) the gene function activity, that can lead to deregulation of the drug adsorption, distribution, metabolism and excretion (ADME) (Iskakova et al, 2016) and consequently lead to therapeutic failures and/or adverse drug reactions.…”

Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population

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