Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study

Abstract

In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were selected to genotype analysis according to exclusion criteria. Patients were divided into the following groups: Group I: control patients (n = 78) without and Group II.: study patients (n = 54) with evidence of perioperative myocardial infarction. Genotyping for GSTP1 A (Ile105Ile/Ala113Ala), B (Ile105Val/Ala113Ala) and C (Ile105Val/Ala113Val) alleles was performed by using real-time-PCR. The heterozygous AC allele was nearly three times elevated (18.5 vs. 7.7 %) in the patients who suffered postoperative myocardial infarction compared to controls. Contrary, we found allele frequency of 14.1 % for homozygous BB allele in the control group whereas no such allele combination was present in the study group. These preliminary results may suggest the protective role for the B and C alleles during myocardial oxidative stress whereas the A allele may represent predisposing risk for cellular injury in patients undergoing cardiac surgery.

Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism

“…The recognition that GST genes are consistently altered in various animal models of lung injury and are among the top genes that accurately predict development of primary graft failure in lung transplant donors (19) certainly points toward these promising directions. Our pilot genetic data may also highlight a role of specific GST gene polymorphism in the development of perioperative myocardial infarction (20), thus extending the paradigm beyond lung ischemia reperfusion injury.…”

Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease

“…Glutathione S-transferase (GST) polymorphism is identified as one of the factors that could lead to an increased incidence of MI during cardiac surgery. To investigate the association between GST polymorphism and MI, Kovacs et al [121] conducted a study on 758 patients that had cardiac surgery. After measuring levels of troponin 1 (T1) and myocardial-based creatine kinase (CKMB), two groups of patients were formed.…”

“…On the other hand, allele AC was detected in a group of patients with MI. Authors suggested that the presence of allele B may have a protective role in the development of MI, while the presence of alleles A and C was associated with increased risk for MI [121].…”

Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

“…The authors concluded that the reduction of glutathione levels in plasma may be an independent risk factor for the development of cardiovascular disease. Kovacs et al . investigated the link between myocardial infarction and glutathione S‐transferase polymorphism in patients that underwent cardiac surgery using genetic tests.…”

“…The authors concluded that the reduction of glutathione levels in plasma may be an independent risk factor for the development of cardiovascular disease. Kovacs et al 35 investigated the link between myocardial infarction and glutathione S-transferase polymorphism in patients that underwent cardiac surgery using genetic tests. The results suggested that the presence of allele B might have a potential role for protecting in the development of myocardial infarction, while the presence of alleles A and C could be associated with an increased risk of myocardial infarction.…”