Polymorphisms in STAT4 are not associated with treatment response and spontaneous clearance of hepatitis C virus in europeans

Asimakopoulos, Anastasia; Mangia, Alessandra; Dore, Gregory J.; Lloyd, Andrew R.; George, Jacob; Eslam, Mohammed

doi:10.1002/hep.28626

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Another highlight of the present study is the differential role of rs7574865 in HBV‐ and HCV‐infected Caucasian patients. In a recent study, we did not observe any association between rs7574865 genotype and spontaneous HCV viral clearance, response to IFN‐α therapy, fibrosis severity or fibrosis progression (n = 1211) . At present, it is not clear why STAT4 rs7574865 predicts liver injury only in patients with CHB.…”

Section: Discussionmentioning

confidence: 99%

“…We recently reported that rs7574865 does not play any role in either the response to interferon‐based treatment, spontaneous clearance or fibrosis progression in Caucasian patients with chronic hepatitis C . Whether this lack of association is due to ethnic differences or more likely to differences in the hepatic immune response to HBV and HCV is unknown, but intriguing.…”

Section: Introductionmentioning

confidence: 99%

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A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B

Sharkawy

Thabet

Lampertico³

et al. 2018

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B

Sharkawy

Thabet

Lampertico³

et al. 2018

Aliment Pharmacol Ther

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“…The natural history of viral hepatitis infection including HBV infection exhibited a marked inter-individual variation, indicating a pivotal role for genetic basis in shaping the outcome of such patients (16). The last years have witnessed multiple GWAS studies, which revealed multiple risk variants for common complex diseases including infectious diseases (8,9,(17)(18)(19)(20). However, to date, most studies were conducted in either Caucasian or other Asian populations, with very limited data in the Pakistani population, while Pakistan is a country with a very high prevalence of HBV infection and a large population.…”

Section: Discussionmentioning

confidence: 99%

PNPLA3 and TM6SF2, but Not MBOAT7, Are Associated with Steatosis and HBV Viral Persistence in Pakistani Population

Jalil

Arshad

Khan

et al. 2020

Jundishapur J Microbiol

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Background: Hepatitis B infection has an intimate relationship with lipids. The role of lipid-related variants remains unknown in the risk of hepatitis B infection persistence and steatosis in the Pakistani population. Recently, three GWAS-based polymorphisms in the TM6SF2, PNPLA3, and MBOAT7 genes have suggested being associated with steatosis and/or liver injury. However, the role of these variants is unknown in Hepatitis B virus (HBV) persistence and steatosis in the Pakistani population. Objectives: We determined whether TM6SF2, PNPLA3, and MBOAT7 genetic variations are associated with HBV chronicity and hepatic steatosis in the Pakistani population. Methods: A total of 297 patients visiting the Hayat Abad Medical Complex in Peshawar were included in this study. Clinical analysis, along with genotyping of SNPs in the PNPLA3, TM6SF2, and MBOAT genes, was performed using the TaqMan genotyping assay. Logistic regression analysis, along with other tests as appropriate, was used to determine the association of the analyzed SNPs with HBV persistence, chronicity, and hepatic steatosis in the analyzed set of patients. Results: In 297 subjects (240 HBV patients and 57 healthy controls), PNPLA3 rs738409 (OR: 0.43, 95% CI: 0.23 -0.81, P = 0.009) and TM6SF2 rs58542926 (P = 0.018) genotypes were independently associated with the risk of chronic HBV infection, but not MBOAT rs641738 (OR: 1.3, 95% CI: 0.64 -2.62, P = 0.454). We also observed that the PNPLA3 rs738409 GG genotype was associated with 2.97fold and TM6SF2 rs58542926 genotype T allele with 1.54-fold increased risk of steatosis. Conclusions: PNPLA3 rs738409 and TM6SF2 rs58542926, but not MBOAT rs641738, were the risk variants for HBV persistence and steatosis in the Pakistani population.

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“…An intriguing finding of our work was the differential impact of the STAT4 variant on hepatic inflammation and fibrosis in chronic hepatitis B compared to chronic hepatitis C. We have shown that this variant is not associated with either the response to interferon‐based treatment, spontaneous clearance or fibrosis progression in chronic hepatitis C . This suggests that there are differential immune pathway responses between these two hepatitis viruses.…”

mentioning

confidence: 81%

Editorial: STAT‐4 polymorphism ‐ a tool to personalise clinical practice in chronic HBV infection. Authors’ reply

Sharkawy

George

Eslam

2018

Aliment Pharmacol Ther

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Polymorphisms in STAT4 are not associated with treatment response and spontaneous clearance of hepatitis C virus in europeans

Cited by 4 publications

References 4 publications

A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B

A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B

PNPLA3 and TM6SF2, but Not MBOAT7, Are Associated with Steatosis and HBV Viral Persistence in Pakistani Population

Editorial: STAT‐4 polymorphism ‐ a tool to personalise clinical practice in chronic HBV infection. Authors’ reply

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