Polymorphisms in the Vitamin D Receptor Gene Are Associated With Periodontal Disease

Brito, Rui Barbosa de; Scarel‐Caminaga, Raquel Mantuaneli; Trevilatto, Paula Cristina; Souza, Ana Paula de; Barros, Silvana P.

doi:10.1902/jop.2004.75.8.1090

Cited by 90 publications

(83 citation statements)

References 26 publications

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“…When the three SNPs were analyzed together as haplotypes, we found a significant association between the haplotypes and periodontitis susceptibility (Tables 4 and 5). Similar findings were observed with the same population in a previous study (Kim et al, 2009) and in other studies of Brazilian individuals in which IL10 and a vitamin D receptor (de Brito Junior et al, 2004) were examined. These previous studies corroborate the idea that haplotypes are more powerful in detecting susceptibility alleles than individual polymorphisms and that they may give more information on the disease.…”

Section: Discussionsupporting

confidence: 91%

Association of Haplotypes in theCXCR2Gene with Periodontitis in a Brazilian Population

Viana

Kim

Curtis

et al. 2010

DNA and Cell Biology

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CXCR-2 is a receptor of interleukin-8, which is involved in acute and chronic inflammatory processes. Polymorphisms in the CXCR2 gene have been associated with chronic inflammatory conditions. The aim of this study was to investigate whether the þ785(C=T), þ1208(T=C), and þ1440(G=A) single-nucleotide polymorphisms (SNPs) in the CXCR2 gene, as well as their haplotypes, are associated with susceptibility to periodontitis in Brazilians. DNA was extracted from the buccal epithelial cells of 487 individuals (control ¼ 215; periodontitis ¼ 272). The SNPs were investigated using the sequence-specific primer-polymerase chain reaction method. Associations between the polymorphisms and subject phenotypes were analyzed using the chi-squared statistical test, followed by univariate and multivariate logistic regression modeling. Haplotypes were reconstructed using the expectation-maximization algorithm, and differences in haplotype distribution between the groups were analyzed to estimate genetic susceptibility for periodontitis development. Univariate and multivariate analysis revealed that age, skin color, and smoking status were associated with periodontitis. The þ1440 GG genotype was shown to be protective against periodontitis in both univariate and multivariate analysis (odds ratio [OR] adjusted ¼ 0.42; 95% confidence interval [CI] ¼ 0.19, 0.96). A similar relevant result for the þ1440 GG was obtained in an alternative analysis considering a subgroup containing only white nonsmokers (OR ¼ 0.37; 95% CI ¼ 0.15, 0.92). White nonsmokers with the CTG=TCG haplotype appeared to be genetically protected against the development of periodontitis (OR ¼ 0.29; 95% CI ¼ 0.09, 0.89), while those carrying the CTG=TCA haplotype were more susceptible to the development of periodontitis (OR ¼ 2.08; 95% CI ¼ 1.24, 3.51). In conclusion, the þ1440 SNP and some haplotypes are associated with periodontitis in Brazilian individuals.

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Section: Discussionsupporting

confidence: 91%

Association of Haplotypes in theCXCR2Gene with Periodontitis in a Brazilian Population

Viana

Kim

Curtis

et al. 2010

DNA and Cell Biology

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“…Finally, vitamin D is known to be critical to the maintenance of a constant relationship between calcium and phosphate ions, which are key factors in the strengthening and protection of teeth. The starting point of dental caries is demineralization of the dental hard tissues, that is, the dissolution of calcium from the hydroxyapatite crystals that form the backbone of enamel (Brito et al, 2004). Ninety nine percent of the total bodily calcium has been estimated to exist in the bones and teeth.…”

Section: Discussionmentioning

confidence: 99%

“…However, the activity of its receptor is influenced by polymorphisms in the VDR gene (Valdivielso and Fernandez, 2006), located in chromosome 12q13 and encoding a nuclear receptor-transcription factor. Some studies have suggested that such polymorphisms in the coding region may affect the receptor protein by altering its expression level and/or modulating its affinity for vitamin D, which in turn modulates its calcium homeostasis and metabolism (Brito et al, 2004). Polymorphisms in the VDR gene may also affect the expression of osteoblast genes (such as osteocalcin) via the trans-acting regulation of these genes (Morrison et al, 1992), and has even been implicated in susceptibility to pulmonary tuberculosis (Liu et al, 2004;Sharma et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population

Hu¹,

Li²,

Zhou³

et al. 2015

Genet. Mol. Res.

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“…Vice-versa, in combination with Fc-gammaRIIIB genotype, BsmI may be associated with generalized early-onset periodontitis or, as demonstrated by de Brito, when the allele B of BsmI polymorphism and the T allele of TaqI polymorphism were present, the TB haplotype seemed to increase susceptibility to chronic periodontitis (37)(38)(39). The findings of Gunes indicates that the ApaI, BsmI and TaqI polymorphisms analyzed individually, did not show statistically significant differences in their frequencies in a Turkish population of healthy subjects and patients affected by chronic periodontal disease while, also in this case, the presence of allele T (TaqI) and B (BsmI) in the haplotype BT is over-represented among chronic periodontal cases (40).…”

Section: Bsmimentioning

confidence: 97%

Vitamin D: relevance in dental practice

Martelli¹

2014

ccmbm

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SummaryObjective. The potential role of VDR gene variations in modulating periodontal susceptibility have been a subject of scientific investigations. The aim of this paper is to perform a literature review of the potential correlation between Vitamin D Receptor (VDR) gene polymorphisms and periodontal disease. Materials and methods. A PubMed literature search was made using "vitamin d receptor polymorphisms periodontal disease" as keys words. Only clinical studies in "Humans" as species and "English" as language were considered. Titles and abstracts of all identified records were examined to determine if the candidate articles contained sufficient information on the association of the VDR polymorphisms and the risk of development periodontal disease. Conclusions. Vitamin D may affect the risk of developing periodontal disease via an effect on bone mineral density or via immunomodulatory effects. There are scientific evidences about the correlation between some VDR polymorphisms, periodontitis and bone metabolism. The use of new simple and economics diagnostic techniques of genetic screening, allows to the dental specialists to identify periodontal patients with possible decreased bone mineral density. The complete acquisition of awareness by dentists of the strong relationship between skeletal bone density with periodontal health and osteointegrated implant success, could open a new therapeutic approach for periodontists with an important role in the early detection of osteoporosis and a better patient compliance of the periodontal therapy.

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Polymorphisms in the Vitamin D Receptor Gene Are Associated With Periodontal Disease

Abstract: TaqI and BsmI polymorphisms of the VDR gene are associated with clinical attachment loss due to periodontal disease in a Brazilian population. These findings suggest that VDR genotype might be a risk indicator for susceptibility to chronic periodontitis.

Cited by 90 publications

References 26 publications

Association of Haplotypes in theCXCR2Gene with Periodontitis in a Brazilian Population

Association of Haplotypes in theCXCR2Gene with Periodontitis in a Brazilian Population

Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population

Vitamin D: relevance in dental practice

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