Polymorphisms in XPD and hOGG1 and Prostate Cancer Risk: A Meta-Analysis

Zhu, Shimiao; Zhang, Hui; Tang, Yang; Wang, Jianmin

doi:10.1159/000339603

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…For XPD , the Asp312Asn (rs1799793) polymorphism was consistently shown to be associated with an increased risk of PCa in Asian populations in both additive and recessive genetic models [29–33] but not in Caucasian or African populations. For example, a protective association was observed between Asp312Asn (rs1799793) genotypes and PCa risk in Caucasian populations in one meta-analysis [31] but not in other three meta-analyses [29, 30, 33]. Likewise, an association was observed between Asp312Asn (rs1799793) genotypes and PCa risk in African populations in three meta-analyses [31–33] but not in other two meta-analyses [29, 30].…”

Section: Discussionmentioning

confidence: 99%

“…For example, a protective association was observed between Asp312Asn (rs1799793) genotypes and PCa risk in Caucasian populations in one meta-analysis [31] but not in other three meta-analyses [29, 30, 33]. Likewise, an association was observed between Asp312Asn (rs1799793) genotypes and PCa risk in African populations in three meta-analyses [31–33] but not in other two meta-analyses [29, 30]. Similar to the previously published studies, we did not find any association between XPD Lys751Gln (rs13181) genotypes and PCa in Chinese populations.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Wang

et al. 2016

Oncotarget

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Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64–1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Wang

et al. 2016

Oncotarget

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“…In two meta-analyses, the XPD Lys751Gln and hOGG1 Ser326Cys polymorphisms were found associated with prostate cancer but not with hepatocellular carcinoma [17,18]. Zhang et al, in their study on diabetic patients reported that XPD Lys751Gln was not, however, the hOGG1 Ser326Cys polymorphism was associated with age related cataract [19].…”

Section: Discussionmentioning

confidence: 97%

Investigation of DNA repair genes XPD and hOGG1 in type 2 Diabetes mellitus

Yigitbasi¹,

Yurdum²,

Yılmaz³

et al. 2017

Med-Science

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Increased oxidative stress in type 2 diabetes cause to the accumulation of DNA damage and results diabetic complications. Xeroderma pigmentosum complementation group D (XPD) and human oxoguanine glycosylase 1 (hOGG1) are genes involved in the repair of oxidative DNA damage. In this study, we aimed to evaluate association between XPD Lys751Gln and hOGG1 Ser326Cys polymorphisms with type 2 diabetes mellitus (T2DM) in the Turkish population. Seventy-one T2DM patients and 54 healthy individuals were incorporated into this study. DNA was extracted from whole blood. The Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (RFLP) techniques were used. There was statistically significant difference between patient and control groups in the genotype distribution of XPD Lys751Gln polymorphism (p˂0.05). While the Lys/Lys genotype was found significantly higher in control group, the Lys/Gln was higher in patients. (p˂0.05). There was no significant difference between groups in the genotype distribution of hOGG1 Ser326Cys polymorphism. Despite the small number of subjects included in the study, it could be interpreted that the Lys/Gln genotype of XPD Lys751Gln polymorphism may be contributing to the development of diabetes.

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“…According to current literature, single nucleotide polymorphisms in these two BER genes are correlated with various cancers [13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms (SNPs) of hOGG1 and XRCC1 DNA repair genes and the risk of ovarian cancer in Polish women

et al. 2015

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The aim of this study was to determine single nucleotide polymorphisms in hOGG1 (Ser326Cys (rs13181)) and XRCC1 (Arg194Trp (rs1799782)) genes, respectively, and to identify the correlation between them and the overall risk, grading and staging of ovarian cancer in Polish women. Our study comprised 720 patients diagnosed with ovarian cancer and 720 healthy controls. The genotype analysis of hOGG1 and XRCC1 polymorphisms was performed using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (PCR-RFLP). Odds ratios (OR) and 95 % confidence intervals (CI) for each genotype and allele were calculated. Results revealed an association between hOGG1 Ser326Cys polymorphism and the incidence of ovarian cancer. Variant Cys allele of hOGG1 increased the overall cancer risk (OR 2.89; 95 % CI 2.47-3.38; p < .0001). Moreover, ovarian cancer grading remained in a relationship with both analysed polymorphisms; G1 tumours presented increased frequencies of hOGG1 Cys/Cys homozygotes (OR 18.33; 95 % CI 9.38-35.81; p < .0001) and XRCC1 Trp/Trp homozygotes (OR 20.50; 95 % CI 10.17-41.32; p < .0001). Furthermore, G1 ovarian cancers displayed an overrepresentation of Cys and Trp allele. In conclusion, hOGG1 Ser326Cys and XRCC1 Arg194Trp polymorphisms may be regarded as risk factors of ovarian cancer.

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Polymorphisms in XPD and hOGG1 and Prostate Cancer Risk: A Meta-Analysis

Cited by 18 publications

References 41 publications

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Investigation of DNA repair genes XPD and hOGG1 in type 2 Diabetes mellitus

Single nucleotide polymorphisms (SNPs) of hOGG1 and XRCC1 DNA repair genes and the risk of ovarian cancer in Polish women

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