Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population

Sobti, Ranbir Chander; Berhane, Nega; Mahedi, Salih Abdul; Kler, Rupinder; Hosseini, Seyed Ali; Kuttiat, Vijish; Wanchu, Ajay

doi:10.1007/s11010-009-0293-0

Cited by 19 publications

(12 citation statements)

References 45 publications

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“…Genetic polymorphisms are capable of influencing the immune response during inflammation and tissue damage [27]. Our observation that the wild-type AA genotype was present in the highest frequencies in both the patients and controls suggests the lack of a direct modulation of infection with SNPs with the infection, which corroborated previous results obtained with HCV carriers [28].…”

Section: Discussionsupporting

confidence: 91%

HBV Viral Load and Liver Enzyme Levels May Be Associated with the WildMBL2AA Genotype

Moura

Amoras

Araújo

et al. 2017

Mediators of Inflammation

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The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92), and a noninfected control group (n = 300) were investigated. The presence of polymorphisms was detected using a real-time polymerase chain reaction to correlate with liver disease pathogenesis and fibrosis staging according to the Metavir classification. The genotypic and allelic frequencies showed no significant differences between the groups, but patients with active HBV and the wild AA genotype presented a positive correlation between increased transaminase and HBV DNA levels and the presence of mild to moderate fibrosis. Patients with HCV and the wild AA genotype presented mild inflammation and higher HCV RNA levels, although the same association was not observed for the fibrosis scores. The results suggest that the mutations in exon 1 of the MBL2 gene do not contribute directly to the clinical and laboratory features of HCV and HBV infections, but further studies should be performed to confirm whether the wild AA genotype has indirect effect on disease progression.

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Section: Discussionsupporting

confidence: 91%

HBV Viral Load and Liver Enzyme Levels May Be Associated with the WildMBL2AA Genotype

Moura

Amoras

Araújo

et al. 2017

Mediators of Inflammation

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“…With regard to HIV-1, cytokines have been identified as important tools toward better understanding of the profound interactions occurring between HIV-1 and the human immune system. Moreover, cytokine genes have been implicated to influence the rate of disease progression in HIV-1 seropositive patients either positively or negatively [6,7,26,27]. …”

Section: Discussionmentioning

confidence: 99%

IL-18 Gene Promoter Region 607C/A Polymorphism in HIV-1 Infected North Indian Population

Sobti¹,

Sharma²,

Abitew³

et al. 2011

Balkan Journal of Medical Genetics

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Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and in its progression to acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates immune responses and plays a pathogenic role in HIV-1 infection by enhancing viral replication. Single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter region may lead to altered transcriptional activity and IL-18 production, and may account for variation in the risk of HIV-1 infection. We have investigated the association between IL-18 promoter polymorphism −607C>A and HIV-1 infection through a case-control study of 500 patients with HIV-1/AIDS and an equal number of age and sex matched controls in a north Indian population. Genotyping using sequence specific primer-polymerase chain reaction (SSP-PCR) showed a statistically significant reduced risk of HIV-1 infection for the A>A genotype [odds ratio (OR) = 0.57, 95% confidence interval (95% CI) = 0.33–0.98, p = 0.040], but not for the C>A genotype (OR = 0.87, 95% CI = 0.66–1.14, p = 0.321). We concluded that the −607A allele of the IL-18 gene promoter polymorphism may play a protective role against the progression of HIV-1 infection in this population.

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“…Among these, the most studied SNP at position -174 (IL-6 -174G/C) can modify transcriptional regulation and cytokine levels, and has an impact on inflammatory phenotypes (Fishman et al, 1998). Previous studies have shown that IL-6 -174 G/C polymorphism is associated with the development and progression of various human diseases including systemic lupus erythematosus, neuroblastoma, coronary heart disease, HIV/AIDS, and nephritis (Sobti et al, 2010;Santos et al, 2011;Yin et al, 2012;Totaro et al, 2013;Yang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk

Nie¹,

Xie

Cao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Previous studies examining the association between interleukin-6 (IL-6) -174G/C polymorphism and psoriasis risk have produced inconsistent results. The aim of this study was to offer a comprehensive review of the association between IL-6 -174G/C polymorphism and psoriasis risk through a meta-analysis. Literature search of PubMed and Embase databases was conducted to identify all eligible studies published before October 29, 2015. Four case-control studies involving 651 psoriasis cases and 552 controls were included in this meta-analysis. Data were extracted, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the associations. Combined analysis revealed a significant association between this polymorphism and psoriasis risk under the recessive model (OR = 1.69, 95%CI = 1.12-2.55, P = 0.013 for GG vs GC + CC), and the heterozygous comparison model (OR = 1.70, 95%CI = 1.29-2.23, P < 0.001 for GG vs GC). However, no significant association was observed under the allelic model (OR = 1.37, 95%CI = 0.99-1.89, P = 0.060 for G vs C), the dominant model (OR = 1.25, 95%CI = 0.92-1.71, P = 0.152 2 G. Nie et al. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 15 (2): gmr.15028255 for GG + GC vs CC), and the homozygote comparison model (OR = 1.62, 95%CI = 0.79-3.32, P = 0.186 for GG vs CC). We conclude that the IL-6 -174G/C polymorphism contributes to psoriasis risk. However, further studies should be performed to validate our results.

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Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population

Cited by 19 publications

References 45 publications

HBV Viral Load and Liver Enzyme Levels May Be Associated with the WildMBL2AA Genotype

HBV Viral Load and Liver Enzyme Levels May Be Associated with the WildMBL2AA Genotype

IL-18 Gene Promoter Region 607C/A Polymorphism in HIV-1 Infected North Indian Population

Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk

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