Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation

Wang, Liang‐Jen; Chan, Wen-Ching; Chou, Miao-Chun; Chou, Wen-Jiun; Lee, Min-Jing; Lee, Sheng-Yu; Lin, Pao‐Yen; Yang, Yi‐Hsin; Yen, Cheng‐Fang

doi:10.1038/srep45595

Cited by 10 publications

(5 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exposure of STS only possesses in the specific areas of the brain, which are basal ganglia, frontal cortex, and thalamus (highly affected regions whose physiological function have a direct concern with ADHD) (Stergiakouli et al., 2011). The number of evidence ensures the role of STS in ADHD, cytogenetic deletions in males lead to encompassing the gene, which further leads to an increase in the susceptibility to disorder (Brookes et al., 2010; Wang et al., 2017). The DHEA(S) level has an inverse relationship with the symptomatology of ADHD, which can be enhanced by MPH treatment (Lee et al., 2008; Pallanti & Salerno, 2020).…”

Section: Animal Models Of Adhdmentioning

confidence: 99%

“…This model is based upon the number of findings that suggest the spontaneously hypertensive rat (SHR) model as an excellent hyperactive model to study ADHD (Leffa et al., 2018; Wang et al., 2017). According to the principle, the model is based on inbred strain derived from the Wistar‐Kyoto (WK) rat, there are several up‐regulatory as well as dawn‐regulatory pathological pathways that makes this model more reliable, For example, the impaired release of DA, due increase in D5 and D1 receptors density presynaptically, alteration in the fashion of release of noradrenergic system, down‐regulation of beta‐adrenoreceptors and various other aspects help to shape out this model and provide good face, predictive validities.…”

Section: Animal Models Of Adhdmentioning

confidence: 99%

See 1 more Smart Citation

Animal models of attention‐deficit hyperactivity disorder (ADHD)

Rahi

Kumar

2021

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Attention‐deficit hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder characterized by three primary symptoms hyperactivity, attention deficit, and impulsiveness, observed in both children and adults. In childhood, this disorder is more common in boys than in girls, and at least 75% will continue to suffer from the disorder until adulthood. Individuals with ADHD generally have poor academic, occupational, and social functioning resulting from developmentally inappropriate levels of hyperactivity and impulsivity, as well as impaired ability to maintain attention on motivationally relevant tasks. Very few drugs available in clinical practice altogether abolish the symptoms of ADHD, therefore, to find new drugs and target it is essential to understand the neuropathological, neurochemical, and genetic alterations that lead to the progression of ADHD. With this contrast, an animal study is the best approach because animal models provide relatively fast invasive manipulation, rigorous hypothesis testing, as well as it provides a better angle to understand the pathological mechanisms involved in disease progression. Moreover, animal models, especially for ADHD, serve with good predictive validity would allow the assessment and development of new therapeutic interventions, with this aim, the present review collect the various animal models on a single platform so that the research can select an appropriate model to pursue his study.

show abstract

Section: Animal Models Of Adhdmentioning

confidence: 99%

Section: Animal Models Of Adhdmentioning

confidence: 99%

Animal models of attention‐deficit hyperactivity disorder (ADHD)

Rahi

Kumar

2021

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…Each factor index, as well as the FSIQ, has a population mean of 100 and a standard deviation of 15. The WISC-IV has been applied for Taiwanese school-aged children in several clinical studies [38,39].…”

Section: Neurocognitive Assessmentsmentioning

confidence: 99%

Cognitive development of children with Kawasaki Disease and the parenting stress of their caregivers

Wang

Tsai

Chang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background Kawasaki disease (KD) is an acute form of febrile vasculitis that occurs in early childhood. The multi-systemic vasculitis common in KD patients may influence blood perfusion in the brain, and thus caregivers of KD children may feel stress with regard to caring for them. Intravenous immunoglobulin (IVIG) infusion is the standard treatment for acute KD, and the most serious complication of KD is coronary artery aneurysms (CAL). This study aimed to investigate the relationships between KD heterogeneity and the risk of patients’ cognitive impairment or caregivers’ parenting stress. Methods This cross-sectional study consisted of 176 patients with KD (mean age: 5.5 years, 60.8% male) and 85 healthy children (mean age: 6.4 years, 54.1% male). Based on the children’s age, each KD patient and control subject was administered an assessment using the Mullen Scales of Early Learning or the Wechsler Intelligence Scale, and parenting function of their caregivers was assessed using the Parenting Stress Index-Short Form (PSI). Results We observed no significant differences in any developmental index, cognitive function, or parenting stress between KD patients and controls. Among the KD children, IVIG administration nor CAL was associated with children’s cognitive scores. However, the caregivers of patients who had CAL suffered from greater PSI total scores than those of patients without CAL (p = 0.019). Furthermore, the caregivers who had education levels of a master’s degree or above showed less parenting stress than those who had an education level of college (p = 0.010) or lower (p = 0.021). Conclusion No significant differences in developmental index, cognitive function or parenting stress between KD patients and controls. In KD patients, neither IVIG response nor CAL appear to have a relationship with development milestones or cognitive function. However, caregivers’ education is associated to parenting stress, and caregivers of KD patients who developed CAL may feel stress about the unpredictable sequela caused by CAL for their children. Such caregivers may require support to fulfill their parenting roles.

show abstract

“…65,67 Deficiencies in the production of this enzymes are the etiology of diseases, can be fatal and incompatible with life, making them essential to the physiology. 68 69 Further, DHEA can be reduced to androstenediol by 17βhydroxysteroid dehydrogenase 1 (17β-HSD1; HSD17B1). 70 The isoenzymes 3β-hydroxysteroid dehydrogenase 1/2 (3β-HSD; HSD3B1 and HSD3B2, respectively) are responsible to convert DHEA into androstenedione and androstenediol into testosterone.…”

Section: Sex Steroid Hormones and Physiologymentioning

confidence: 99%

“…Androgen hormones biosynthesis. DHEA-S is converted in DHEA by the catalysis action of steroid sulfatase enzyme (STS; STS), while sulfotransferase 2A1 (ST2A1; SULT2A1) do the reverse way by conjugating sulfate to DHEA 69. Further, DHEA can be reduced to androstenediol by 17βhydroxysteroid dehydrogenase 1 (17β-HSD1; HSD17B1) 70.…”

mentioning

confidence: 99%

The role of sex steroid hormones in Crohn\'s disease

Silva¹

View full text Add to dashboard Cite

Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation

Cited by 10 publications

References 69 publications

Animal models of attention‐deficit hyperactivity disorder (ADHD)

Animal models of attention‐deficit hyperactivity disorder (ADHD)

Cognitive development of children with Kawasaki Disease and the parenting stress of their caregivers

The role of sex steroid hormones in Crohn\'s disease

Contact Info

Product

Resources

About