Polymorphisms of the CYR61 gene in patients with acute myeloid leukemia in a Han Chinese population

Abstract

It was demonstrated in previous studies that cysteine-rich angiogenic inducer 61 (Cyr61) plays vital roles in hematological disorders, and we have already reported that the Cyr61 protein is a tumor promoter in acute myeloid leukemia (AML). Here, we investigated the association between CYR61 gene polymorphisms and susceptibility to AML.We genotyped 2 single-nucleotide polymorphisms (rs2297141 and rs6576776) in the region of the CYR61 gene by improved multiplex ligase detection reaction genotyping assays in a total of 275 samples, including samples from 137 AML patients and 138 healthy controls. Chi-squared tests and logistic regression analysis were performed to compare the different distributions of the genotypes and alleles between patients and healthy controls.The rs2297141 A allele was associated with lower risk of AML compared with the G allele (odds ratio [OR] = 0.704, 95% confidence interval [CI] = 0.503–0.985, P = .04) in both the dominant (OR = 0.447, 95% CI = 0.22–0.909, P = .025, AA vs GG) and recessive inheritance models (OR = 0.419, 95% CI = 0.23–0.763, P = .004, AA vs GA + GG). Although the distribution of the rs6576776 alleles was not different between patients with AML and normal controls, the CC genotype significantly increased the risk of AML in the dominant inheritance model (OR = 6.064, 95% CI = 1.303–28.216, P = .01, CC vs GG) and the recessive inheritance model (OR = 5.937, 95% CI = 1.291–27.306, P = .01, CC vs GC + GG). Additionally, it was shown that the rs2297141 and rs6576776 genotypes were associated with AML-M5 and AML-M2, respectively.Our findings indicated that genetic polymorphisms in the CYR61 gene may be considered potential AML risk factors in the Han Chinese population.

Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations

“…The polymorphism rs3753794 of the CCN1 gene was shown to be associated with plasma high-density lipoprotein–cholesterol levels in obese individuals [ 13 ]. Chang-Chun Niu et al findings indicated that rs6576776 in the CCN1 gene may be considered potential acute myeloid leukemia risk factors in the Han Chinese population [ 14 ]. So far, the function of rs954353 has not been studied at the cellular and animal levels.…”

Genetic variants of glutathione S-transferase and the risk of acute myeloid leukemia in a Saudi population

“…AML is associated with favorable, intermediate, and unfavorable risks as per the national comprehensive cancer networks (Xu et al, 2017). Genomic changes play a vital role in AML (Niu et al, 2018). The recent world health organisation (WHO) classifications defines AML with biallelic mutations of CEBPA is recognized as distinct category with favorable prognosis (Ng et al, 2017).…”