Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer

Riener, Eva-Katrin; Hefler, Lukas; Grimm, Christoph; Galid, A.; Zeillinger, Robert; Tong-Cacsire, Dan; Gitsch, G.; Leodolter, Sepp; Tempfer, Clemens

doi:10.1016/j.ygyno.2004.03.030

Cited by 32 publications

(23 citation statements)

References 28 publications

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“…Moreover, evidence can also be found in the literature associating eNOS alleles with different parameters concerning ovarian and vulvar cancers (21,22). In particular, polymorphisms rs2070744 (also known as T786C) and rs1799983 (also named Glu298Asp), have been previously shown to be functional or, at least associated to other pathologies (23)(24)(25)(26)(27)(28).…”

Section: Introductionmentioning

confidence: 93%

Genetic analysis of Caveolin-1 and eNOS genes in colorectal cancer

Conde

Ramírez-Lorca²,

López-Jamar³

et al. 2006

Oncol Rep

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Abstract. Caveolae are involved in physical compartmentalization between different groups of signaling events. Its main component, CAV1, modulates different pathways in cellular physiology. The emerging evidence pointing to the role of CAV1 in cancer led us to study whether different alleles of this gene are associated with colorectal cancer (CRC). Since one of the most characterized enzymes regulated by CAV1 is eNOS, we decided to include both genes in this study. We analyzed five SNPs in 360 unrelated CRC patients and 550 controls from the general population. Two of these SNPs were located within eNOS and three within the CAV1 gene. Although haplotype distribution was not associated with CRC, haplotype TiA (CAV1) was associated with familiar forms of CRC (p<0.05). This was especially evident in CRC antecedents and nuclear forms of CRC. If both CG (eNOS) and TiA (CAV1) haplotypes were taken together, this association increased in significance. Thus, we propose that CAV1, either alone or together with eNOS alleles, might modify CRC heritability.

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Section: Introductionmentioning

confidence: 93%

Genetic analysis of Caveolin-1 and eNOS genes in colorectal cancer

Conde

Ramírez-Lorca²,

López-Jamar³

et al. 2006

Oncol Rep

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“…Although several studies with conflicting outcomes have been conducted on eNOS polymorphisms and risk for different types of cancers including prostate, ovarian and vulvar [8][9][10], only one small study (71 cases) has explored the potential association between breast cancer risk and the eNOS -786T > C (but not the 894G > T) polymorphism [11] and no studies have examined these gene variants in relation to breast cancer survival. We evaluated the potential association between the selected genetic polymorphisms in eNOS (-786T > C and 894G > T), two functionally important SNPs, and breast cancer survival, and also assessed whether this association could be modified by clinicopathological phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of eNOS, Hormone Receptor Status, and Survival of Breast Cancer

Choi

Lee

Noh

et al. 2006

Breast Cancer Res Treat

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The endothelial cell-specific form of nitric oxide synthase (eNOS) may play an important role in tumor progression via angiogenesis or apoptosis. We studied eNOS -786T > C and 894G > T (Glu298Asp), two functionally significant SNPs, in relation to hazard of breast cancer recurrence or death in 873 women with incident, non-metastatic breast cancer, recruited from two teaching hospitals in Seoul, Korea, 1995-2002. Hazards were estimated by Cox proportional hazard models, in relation to genotype, adjusting for hormone receptor status, lymph node involvement, and tumor size. Women carriers of the eNOS -786C allele had significantly increased hazards of breast cancer recurrence or death, compared with women having the TT genotype (HR = 2.1, 95% CI = 1.03-4.33); risks increased up to 3-fold in ER positive cases (HR = 3.2, 95% CI = 0.95-10.50). The hazard was also increased in eNOS 894T carriers, however, it did not reach statistical significance (HR = 1.8, 95% CI = 0.85-3.93). The combined genotypes containing -786C or 894T was associated with a 2.5-fold risk, compared to the TT-GG genotypes, the most dominant genotype combination (95% CI = 1.29-4.68), with the greatest risks in ER positive cases (HR = 4.9, 95% CI = 1.31-18.36). These results indicate that the eNOS -786C polymorphism, and possibly the 894T polymorphism, are associated with breast cancer recurrence and death, particularly in women with ER positive tumors.

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“…However, the results of association studies on these polymorphisms with cancer risk are controversial. [30][31][32][33][34][35] Because the sample sizes of the published studies on polymorphisms in the eNOS gene and cancer risk were relatively small, we hypothesized that functional polymorphisms in the eNOS gene can modulate individual susceptibility to breast cancer, and therefore we tested this hypothesis in a much larger hospital-based case-control study of 421 sporadic breast cancer patients and 423 cancer-free healthy control subjects, with a focus on susceptibility in young (age 55 years) women.…”

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confidence: 99%

Promoter polymorphism (−786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non‐Hispanic white women age younger than 55 years

Lü

Wei

Bondy

et al. 2006

Cancer

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In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high‐sensitivity fluorine MRI strategy. It is shown that the harmful effects of J‐coupling can be eliminated by carefully choosing the bandwidth of the 180° pulses in a spin‐echo sequence. The T2 of the CF3 resonance of the molecule is measured using a multispin‐echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin‐echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin‐echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles. Magn Reson Med 63:1119–1124, 2010. © 2010 Wiley‐Liss, Inc.

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Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer

Cited by 32 publications

References 28 publications

Genetic analysis of Caveolin-1 and eNOS genes in colorectal cancer

Genetic analysis of Caveolin-1 and eNOS genes in colorectal cancer

Genetic Polymorphisms of eNOS, Hormone Receptor Status, and Survival of Breast Cancer

Promoter polymorphism (−786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non‐Hispanic white women age younger than 55 years

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