Polymorphisms of tumor necrosis factor-alpha and breast cancer risk: a meta-analysis

Shen, Chao; Sun, Haiming; Sun, Donglin; Xu, Lei; Zhang, Xuelong; An, Lê Văn; Jia, Xueyuan; Bai, Jing; Chen, Feng; Ye, Yu; Jin, Yan; Yu, Jingcui; Fu, Songbin

doi:10.1007/s10549-010-1184-5

Cited by 49 publications

(36 citation statements)

References 31 publications

(34 reference statements)

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“…Although genotype changes at position –308 of the TNF- α promoter are frequently observed in several cancers [18,19,20], in the subgroup analysis according to the source of controls and ethnicity, no significantly statistical evidence was found for healthy and benign control among Asian and Caucasian subjects in various statistical models for the association between –308 G/A polymorphism and bladder cancer risk. The results of this meta-analysis were consistent with the meta-analysis results of some types of cancer [21], but inconsistent with other meta-analyses [22]. It is conceivable that different types of cancer have different etiopathogeneses.…”

Section: Discussioncontrasting

confidence: 55%

Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

Yang

Lv³

et al. 2012

Urol Int

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There is no consensus on the association between the tumor necrosis factor-α (TNF-α) gene promoter –308 A/G single nucleotide polymorphisms and bladder cancer risk. To obtain a more precise estimation of this correlation, we conducted a meta-analysis. The PubMed, MEDLINE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched for relevant published studies. Seven case-control studies with a total of 1,311 cases and 1,436 controls were identified and analyzed. A notable correlation was observed between the TNF-α genotype and bladder cancer grade (AA+GA vs. GG; odds ratio 1.96, 95% confidence interval 1.37–2.80, p = 0.0002). In summary, this meta-analysis demonstrates that the TNF-α –308 AA+GA genotype may be a marker to the tumor-invasive stage of bladder cancer.

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Section: Discussioncontrasting

confidence: 55%

Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

Yang

Lv³

et al. 2012

Urol Int

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“…In our population, the frequency of this polymorphism was 14% in BC patients and 1% in controls and was identified as a risk factor. Other studies have observed the association between the -308G>A polymorphism and BC (Li et al, 2008;Pooja et al, 2011;Shen et al, 2011).…”

Section: Discussionmentioning

confidence: 91%

“…Furthermore, TNF-α induces the expression of adhesion molecules, facilitating the invasion of metastatic tumor cells (Champ et al, 2012). Multiple studies have found a significant association between this cytokine and increased risk for BC (Fang et al, 2010;Shen et al, 2011), and an increase in the severity of the disease (Azmy et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…The TNF-α-308G>A polymorphism is located in the promoter region of the gene and involves the substitution of a guanine (G) by an adenine (A). This change effects gene expression, increasing production of TNF-α (Cereda et al, 2012) and has been extensively associated with complex diseases, including BC (Azmy et al, 2004;Fang et al, 2010;Shen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women

Gómez-Flores-Ramos¹,

Dios²,

Puebla-Pérez³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with those of 465 Mexican women with breast cancer. The observed genotype frequencies for controls and breast cancer patients were 1 and 14% for AA, 13 and 21% for GA, and 86 and 65% for GG, respectively. We found that the odds ratio (OR) for AA genotype was 2.4, with a 95% confidence interval (95%CI) of 5.9-101.1 (P = 0.0001). The association was also evident when comparing the distribution of the AA-GA genotype in patients in the following categories: 1) premenopause and obesity I (OR = 3.5, 95%CI = 1.3-9.3, P = 0.008), 2) Her-2 neu and tumor stage I-II (OR = 2.5, 95%CI = 1.31-4.8, P = 0.004), 3) premenopause and tumor stage III-IV (OR = 1.7, 95%CI = 1.0-2.9, P = 0.034), 4) chemotherapy non-response and abnormal hematocrit (OR = 2.4, 95%CI = 1.2-4.8, P = 0.015), 5) body mass index and Her-2 neu and III-IV tumor stage (OR = 2.8, 95%CI = 1.2-6.6, P = 0.016), and 6) nodule metastasis and K-I67 (OR = 4.0, 95%CI = 1.01-15.7, P = 0.038). We concluded that the genotypes AA-GA of the -308G>A polymorphism in TNF-α significantly contribute to breast cancer susceptibility in the analyzed sample from the Mexican population.

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“…The rs361525 minor allele is only present in the heterozygous genotype, and has previously been reported to be present at a frequency of 0.1-0.2%, based on different population data (Mohamed et al, 2010;Vázquez-Huerta et al, 2014). Although these polymorphisms have been connected to various diseases, including CRC (Fan et al, 2011;Shen et al, 2011;Cereda et al, 2012;Chu et al, 2012;Gómez Flores-Ramos et al, 2013;Stanilov et al, 2014;Vázquez-Huerta et al, 2014), study results have been inconsistent. The aim of this investigation was to measure TNF-α concentration in the plasma of Mexican CRC patients and determine its relationship with the -308G>A and -238G>A polymorphisms and haplotypes of the TNF-α gene.…”

Section: Introductionmentioning

confidence: 99%

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

et al. 2016

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ABSTRACT. The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295-8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α -308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.

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Polymorphisms of tumor necrosis factor-alpha and breast cancer risk: a meta-analysis

Cited by 49 publications

References 31 publications

Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

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