1981
DOI: 10.1016/s0022-3476(81)80556-2
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Polymorphonuclear leukocyte transfusion for the treatment of sepsis in the newborn infant

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Cited by 99 publications
(33 citation statements)
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“…This concept that NSP depletion is a factor in death from sepsis is strengthened by the observation that new born dogs who were inoculated with bacteria and subsequently developed marrow neutro phil depletion, survived if treated with neu trophil transfusion, but littermates trans fused with equal volumes of plasma or red blood cells died [8]. In other studies survival also improved when septic neutropenic hu man neonates were transfused with irriadated donor granulocytes [7,13].…”
Section: Discussionmentioning
confidence: 99%
“…This concept that NSP depletion is a factor in death from sepsis is strengthened by the observation that new born dogs who were inoculated with bacteria and subsequently developed marrow neutro phil depletion, survived if treated with neu trophil transfusion, but littermates trans fused with equal volumes of plasma or red blood cells died [8]. In other studies survival also improved when septic neutropenic hu man neonates were transfused with irriadated donor granulocytes [7,13].…”
Section: Discussionmentioning
confidence: 99%
“…These results suggest that antibiotic therapy alone may have limited efficacy in preventing many of the early deaths seen in fulminant neonatal gram-negative meningitis. Recent studies have demonstrated that white cell transfusions and fresh frozen plasma may improve survival in neonatal sepsis and meningitis (5,13). Specific antibody to surface antigens of gram-negative bacteria and drugs with anti-endotoxin or antiinflammatory activity should also be evaluated.…”
Section: Discussionmentioning
confidence: 99%
“…With illness, however, these functions may also become compromised (16). Granulocyte transfusions can improve the outcome in neonatal sepsis, indicating that a relative impairment of neonatal neutrophil function does occur during illness (10).…”
Section: Discussionmentioning
confidence: 99%