Polymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function

Alexiewicz, Jadwiga M.

doi:10.7326/0003-4819-123-12-199512150-00004

Cited by 186 publications

(112 citation statements)

References 29 publications

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“…21 Neutrophils from patients with diabetes can have impaired biological responses, including reduced bactericidal activity and impaired chemotaxis. 22,23 Compared with neutrophils from age and sex-matched controls, neutrophils from patients with diabetes adhere with less affinity to endothelial cell monolayers. 24,25 In addition, neutrophils from diabetic patients produce 40% less leukotriene B4 than do neutrophils from healthy volunteers.…”

Section: Wwwajcconlineorgmentioning

confidence: 99%

“…Impaired neutrophil function or altered neutrophilendothelial interactions have been proposed as a possible mechanisms for reduced incidence of respiratory dysfunction. 22,23 Likewise, hyperglycemia can have immunomodulatory effects. Hyperglycemia in itself has an independent effect on neutrophil and endothelial properties, resulting in decreased injury in response to endotoxin.…”

Section: Wwwajcconlineorgmentioning

confidence: 99%

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Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Yang

Salam

Ong

et al. 2011

American Journal of Critical Care

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Background Sepsis is a common complication in patients with diabetes mellitus. In a Western population, risk of respiratory dysfunction was lower in diabetic patients with sepsis. Objective To compare organ dysfunction, particularly respiratory dysfunction, between sepsis patients with and without diabetes mellitus in an Asian population. Method Hospital discharge data were collected for the period 2004 through 2008. Patients with sepsis, diabetes mellitus, and organ dysfunction were identified by using the International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification codes. Results Of the 383 238 patients hospitalized during the 5 years, 2943 of the 9221 who had sepsis also had diabetes (31.9%).The most common organ dysfunctions in patients with sepsis were renal (31.5%), cardiovascular (19.2%), and respiratory (10.9%). Among patients with sepsis, respiratory dysfunction was less likely in patients with diabetes (9.4%) than in those without (11.6%; P = .002), but renal dysfunction was more likely in patients with diabetes (46.5%) than in those without (24.4%; P < .001). However, only 27.6% of patients with diabetes had a respiratory source of sepsis compared with 33.4% in patients without diabetes (P < .001). Among patients with sepsis, diabetes mellitus was a significant and independent predictor of respiratory dysfunction (odds ratio, 0.80; 95% confidence interval, 0.66–0.98) after adjustments for age, sex, ethnicity, admission to intensive care, number of comorbid conditions, and other infection sources. Conclusion Among an Asian population, respiratory dysfunction in patients with sepsis is less likely to develop in those with diabetes than in those without diabetes.

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Section: Wwwajcconlineorgmentioning

confidence: 99%

Section: Wwwajcconlineorgmentioning

confidence: 99%

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Yang

Salam

Ong

et al. 2011

American Journal of Critical Care

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“…To the Editor: The −1131 T>C (SNP3) polymorphism of apo A-V gene has been associated in some studies to an increase in triglycerides and in few cases to a decrease in HDL-cholesterol. Its frequency is 12% in Afro-Americans, 16% in Hispanics, 6 to 16% in Caucasians and 7% in a Spanish control cohort [1,2,3,4]. The heterozygote subjects for rare SNP3 allele (C/T) are related to an increase in triglycerides in Hispanic and Caucasian men, although these data were not observed in another study where the increase in triglycerides was only statistically significant in homozygotes for the mutated allele [3].…”

Section: )mentioning

confidence: 51%

“…Several aspects of neutrophil dysfunction in Type 2 diabetes have been attributed to the metabolic consequences of hyperglycaemia and normalisation of glycaemia has been associated with an overall improvement in neutrophil function [4]. However, it is unclear whether impaired neutrophil-cytoskeletal remodelling and abnormal trafficking of cell surface antigens in Type 2 diabetes is due to altered metabolism.…”

Section: Observationsmentioning

confidence: 99%

“…Using density gradient centrifugation according to the method described by Sanchez Quesada [5], six LDL subfractions were isolated [1,2,3,4,5,6] from lesser to greater density: LDL1 (1.020-1.026 g/ml), LDL2 (1.026-1.030 g/ml), LDL3 (1.030-1.036 g/ml), LDL4 (1.036-1.043 g/ml), LDL5 (1.043-1.051 g/ml), LDL6 (1.051-1.056 g/ml). Plasma lipase activity was measured according to a previous study [6].…”

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confidence: 99%

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Neutrophil antigen exposure is altered with age in relatives of patients with Type 2 diabetes

et al. 2004

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Effect of Diabetes Mellitus on Endotoxin-Induced Lung Injury

Wright

Nwariaku²,

Clark³

et al. 1999

Arch Surg

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Objective: To examine the effects of diabetes mellitus on lipopolysaccharide (LPS)-induced pulmonary edema and alveolar neutrophil recruitment and activation.Hypothesis: Zucker diabetic fatty rats are resistant to the effects of intratracheal LPS on the extravasation of plasma proteins into the lungs.Design: Zucker diabetic fatty (ZDF) rats (genotype fa/fa) were used as a model of diabetes mellitus, while their normoglycemic heterozygous littermates served as controls. Lipopolysaccharide (Escherichia coli 0111: B4; 100-200 µg) or vehicle (0.25 mL of isotonic sodium chloride solution) was instilled into the airways of ZDF and control rats. Four hours later, pulmonary microvascular dysfunction was assessed by measuring the extravasation of Evans blue dye into the lung. Lipopolysaccharide-induced neutrophil recruitment was assessed by counting the number of neutrophils within the bronchoalveolar lavage fluid and measuring their expression of CD11b/CD18 by fluorescence-activated cell analysis sorting.Results: The LPS (200 µg) induced a 32% increase in Evans blue dye extravasation into the lungs of controls (P = .008) but had no such effect in diabetic animals. Pulmonary extravasation of Evans blue dye in controls was greater than that of ZDF rats both at baseline (P = .002) and in response to 200 µg of LPS (PϽ.001). The LPS upregulated neutrophil CD11b/CD18 expression in diabetic and nondiabetic groups and induced a greater than 50-fold increase in the number of neutrophils within the airways of both control and diabetic groups (PϽ.001). Conclusion:Despite the recruitment of a large number of neutrophils into the lung, the LPS-induced change in pulmonary microvascular permeability in diabetic animals is substantially less than that of nondiabetic controls.

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Polymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function

Abstract: Patients with NIDDM have elevated [Ca2+]i levels in PMNLs. This abnormality is probably induced by hyperglycemia and is primarily responsible for the imparied phagocytosis seen in these patients.

Cited by 186 publications

References 29 publications

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Neutrophil antigen exposure is altered with age in relatives of patients with Type 2 diabetes

Effect of Diabetes Mellitus on Endotoxin-Induced Lung Injury

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