Polyols production during single and mixed substrate fermentations in Debaryomyces hansenii

Gı́rio, Francisco M.; Amaro, Carmen; Azinheira, H; Pelica, Fátima; Amaral-Collaço, M. T.

doi:10.1016/s0960-8524(99)00078-4

Cited by 53 publications

(50 citation statements)

References 32 publications

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“…Chemical production of arabitol is expensive, requiring the use of chromatographic purification steps [2]. Arabitol can also be produced through the biotransformation of appropriate sugars, e.g., those obtained from hydrolyzates of the hemicellulosic fraction of plant biomass [3,4]. So far, the following yeast genera have been used to produce arabitol from L-arabinose: Debaryomyces, Candida, Pichia, Wickerhamomyces, and Saccharomycopsis [1].…”

Section: Introductionmentioning

confidence: 99%

“…Saha and Bothast [4] investigated 49 yeast strains capable of growing on L-arabinose and concluded that Candida entomaea NRRL Y-7785 and Pichia guilliermondii NRRL Y-2075 were superior secretors of L-arabitol (a yield of about 0.7 g/g). Girio et al [3] observed the ability of Debaryomyces hansenii to produce arabitol from L-arabinose in a batch culture at 30°C. Kordowska-Wiater et al [6] reported that C. parapsilosis DSM 70125, C. shehatae ATCC 22984, and P. guilliermondii DSM 70052 were efficient producers of arabitol at concentrations of 14.0 g/l, 8.5 g/l, and 6.9 g/l, respectively, produced from 20 g/l L-arabinose.…”

Section: Introductionmentioning

confidence: 99%

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Application of response surface methodology for the optimization of arabinose biotransformation to arabitol by Candida parapsilosis

2013

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L-arabitol, a polyol with applications in the food and pharmaceutical industries, is secreted by different yeasts, e.g., Candida spp., Pichia spp., and Debaryomyces spp. The process of its biotechnological production is highly dependent on the physical and chemical conditions of culture. The aim of this study was to use statistical response surface methodology (RSM) to optimize the biotransformation of L-arabinose to arabitol by Candida parapsilosis, a yeast species able to assimilate pentoses. Batch cultures of the yeast were prepared following a Plackett-Burman design for seven variables. Following this, rotation speed, temperature, and L-arabinose concentration were chosen for a central composite design (CCD) experiment, which was carried out to optimize the production L-arabitol. The results showed that the optimal levels for the three factors were: rotation speed 150 rpm, temperature 28°C, and L-arabinose concentration 32.5 g/l. The predicted concentration of arabitol after two days of incubation of C. parapsilosis under the above conditions was 14.3 g/l. The value of R2=0.8323 suggested that this model was well-fitted to the experimental data, and this was confirmed during a verification experiment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of response surface methodology for the optimization of arabinose biotransformation to arabitol by Candida parapsilosis

2013

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“…D is the range of allowed values for the parameters, establishing the bounds of the problem's search domain. All the parameters are required to be non-negative but, in order to avoid divisions by zeros we instead set their lower bounds to a value 10 −7 ; the upper bounds were set to biological plausible values, by literature inspection [12] [14] and, in the case of some of the yield coefficients, stoichiometric restrictions.…”

Section: Parameter Estimation As An Optimization Problemmentioning

confidence: 99%

Comparison of GA and PSO performance in parameter estimation of microbial growth models: A case-study using experimental data

Calcada¹,

Rosa²,

Duarte

et al. 2010

IEEE Congress on Evolutionary Computation

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Abstract-In this work we examined the performance of two evolutionary algorithms, a genetic algorithm (GA) and particle swarm optimization (PSO), in the estimation of the parameters of a model for the growth kinetics of the yeast Debaryomyces hansenii. Fitting the model's predictions simultaneously to three replicates of the same experiment, we used the variability among replicates as a criterion to evaluate the optimization result. The performance of the two algorithms was tested using 12 distinct settings for their operating parameters and running each of them 20 times. For the GA, the crossover fraction, crossover function and magnitude of mutation throughout the run of the algorithm were tested; for the PSO, we tested swarms with 3 different types of convergence behavior -convergent with and without oscillations and divergent -and also varied the relative weights of the local and global acceleration constants. The best objective function values were obtained when the PSO fell in the zone of convergence with oscillations or zigzagging, and had a local acceleration larger than the global acceleration.

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“…Os trabalhos centram-se no estudo de diversos fatores que influenciam a bioconversão de xilose em xilitol tais como a concentração inicial de xilose (FELIPE et al, 1997a;MEYRAL et al, 1991;NOLLEAU et al, 1993), a presença de glicose no meio de fermentação (BICHO et al, 1988;SILVA, 2004;GÍRIO et al, 2000;SUGAI, DELGENES, 1995), a fonte de nitrogênio (BARBOSA et al, 1988), o pH (FELIPE et al, 1997a;SLININGER;BOLEN;KUTZMAN, 1990,), a temperatura (BARBOSA et al, 1988) a disponibilidade de oxigênio (ACOSTA; SILVA; FELIPE, 2000), a concentração de células no inóculo (FELIPE et al, 1997b; e o efeito dos compostos inibidores formados durante o processo de hidrólise dos materiais lignocelulósicos (CLARK, MACKIE, 1984;LARSSON et al, 1999, LARSSON et al, 2000.…”

Section: Obtenção De Xilitol Por Via Biotecnológicaunclassified

“…Segundo Gírio et al (2000), altas concentrações de glicose resultam em diminuição das atividades enzimáticas de xilose redutase e xilitol desidrogenase, enzimas-chave da bioconversão de xilose em xiltol. Segundo estes autores, este comportamento é acompanhado do consumo mais rápido de glicose, precedente ao consumo de xilose, nas primeiras horas de fermentação.…”

Section: Presença De Glicoseunclassified

Estudo de viabilidade econômica da produção de xilitol a partir de hidrolisado hemicelulósico de palha de cevada

Moraes¹

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Polyols production during single and mixed substrate fermentations in Debaryomyces hansenii

Cited by 53 publications

References 32 publications

Application of response surface methodology for the optimization of arabinose biotransformation to arabitol by Candida parapsilosis

Application of response surface methodology for the optimization of arabinose biotransformation to arabitol by Candida parapsilosis

Comparison of GA and PSO performance in parameter estimation of microbial growth models: A case-study using experimental data

Estudo de viabilidade econômica da produção de xilitol a partir de hidrolisado hemicelulósico de palha de cevada

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