Polypharmacy and Mortality Among Nursing Home Residents With Advanced Cognitive Impairment: Results From the Shelter Study

Onder, Graziano; Liperoti, Rosa; Foebel, Andrea D.; Fialová, Daniela; Topinková, Eva; Roest, Henriëtte van der; Gindin, Jacob; Cruz-Jentoft, Alfonso J.; Fini, Massimo; Gambassi, Giovanni; Bernabei, Roberto

doi:10.1016/j.jamda.2013.03.014

Cited by 108 publications

(81 citation statements)

References 34 publications

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“…A large Swedish dataset reported that 33.5% of patients were receiving five or more regular medications [24]. In a study of nursing home residents with advanced cognitive impairment, 13.9% of the population were on ten or more regular prescribed medications [12]. Another study in Norway reported that participants with Alzheimer's Disease were treated with a significantly higher number of medications as compared to controls (5.1 vs. 2.9 respectively), even after adjustment for co-morbidity [10].…”

Section: Comparison With Related Workmentioning

confidence: 99%

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Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data

et al. 2016

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1Co-morbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data Word count: 2,303 Competing interestsWe declare the following interests: BG and GM report grants from the Chief Scientist Office ARPG 07/01 during the conduct of the study. Authors' ContributionsBG and SWM conceived the idea of the study. GMcL carried out statistical analysis and drafting of the results and methodology with BG. FC drafted literature review and interpretation of findings with BG, ER and SWM. All authors contributed to draft revisions. All authors approved the final version before submission. SWM is the guarantor for this study. AcknowledgementsThis analysis had no external funding. The original study which created the dataset was funded by Scottish Government Chief Scientist Office Applied Research Programme Grant 07/01. The funder had no role in study design, data collection, data analysis, data interpretation, or writing of the report, or the decision to submit for publication. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. We would like to thank all the practices which gave permission for the data to be used for research and the Primary Care Clinical Informatics Unit at the University of Aberdeen, which provided the data contained herein. The views in this publication are not necessarily the views of the University of Aberdeen, its agents, or employees. We thank Katie Wilde and Fiona Chaloner of the University of Aberdeen, who did the initial data extraction and management. This paper reports a large cross sectional study of polypharmacy and physical comorbidity among older people with dementia.People with dementia had more physical conditions and were also prescribed more medications than those without dementia.This data highlights the importance of integrating specialist and non-specialist care to support complex symptom management.

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Section: Comparison With Related Workmentioning

confidence: 99%

“…Comorbidity and polypharmacy are both associated with worsening effects on cognition, functional ability and survival of individuals with dementia [11,12]. This paper examines a large population sample of people aged 65 years and over, examining prevalence of physical co-morbidity and polypharmacy in people with and without dementia.…”

Section: Introductionmentioning

confidence: 99%

Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data

et al. 2016

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“…Overtreatment of persons with diabetes mellitus is associated with frailty (57-59). Overall, polypharmacy has been associated with a reduction in walking speed and gait strength, disability and mortality (60)(61)(62)(63)(64). Polypharmacy is also related to cognitive decline and delirium (65)(66)(67).…”

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confidence: 99%

Frailty and polypharmacy

Rolland¹,

Morley

2016

The Journal of nutrition, health and aging

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“…The prevalence of adverse drug reactions is documented to be 20-30 % in the 70-79 years age group compared with 3-6 % in the 20-29 years age group [7][8][9][10]. Frequent drugrelated complications result in a higher percentage of acute care admissions (in 6.6-41.3 % of older patients) [11], a higher number of physicianś visits and consequently a significantly greater proportion of total expenditure for drug treatment [11][12][13]. Total drug-related costs are estimated to be three to four times higher than the direct medication costs [14][15][16], and the rational use of drugs in the elderly is of major economic and social concern in many countries worldwide.…”

mentioning

confidence: 99%

Aging of the Population, Clinical Pharmacy Services, and Interdisciplinary Cooperation in the Optimization of Pharmacotherapy in Older Patients

Fialová

Desplenter

2016

Drugs Aging

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Polypharmacy and Mortality Among Nursing Home Residents With Advanced Cognitive Impairment: Results From the Shelter Study

Cited by 108 publications

References 34 publications

Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data

Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data

Frailty and polypharmacy

Aging of the Population, Clinical Pharmacy Services, and Interdisciplinary Cooperation in the Optimization of Pharmacotherapy in Older Patients

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