Polyphasic study of plant- and clinic-associated Pantoea agglomerans strains reveals indistinguishable virulence potential

Völksch, Beate; Thon, Susanne; Jacobsen, Ilse D.; Gube, Matthias

doi:10.1016/j.meegid.2009.09.016

Cited by 49 publications

(38 citation statements)

References 49 publications

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“…Another rapid and reliable approach would be the determination of pathogenic factors in potential bio-inoculant strains by the amplification of genes encoding them. But such laboratory tests need to be validated with a large number of properly identified isolates, since it has been suggested that independent of their origin, all P. agglomerans strains might possess indistinguishable virulence potential (Volksch et al, 2009). The final biosafety of a novel microbial agent, can be determined by acute toxicity tests (usually carried out on small laboratory animals), and its environmental effects on selected animal species like fishes, earthworms, pollinators, etc.…”

Section: Biosafety Of Novel Pgpr Strainsmentioning

confidence: 99%

Novel plant growth promoting rhizobacteria—Prospects and potential

Chauhan¹,

Bagyaraj²,

Selvakumar

et al. 2015

Applied Soil Ecology

202

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Section: Biosafety Of Novel Pgpr Strainsmentioning

confidence: 99%

Novel plant growth promoting rhizobacteria—Prospects and potential

Chauhan¹,

Bagyaraj²,

Selvakumar

et al. 2015

Applied Soil Ecology

202

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“…This is also true for P. ananatis , P. septica , and P. dispersa , which are known for causing disease in onion and sugar cane plants, but have been implicated in multiple cases of bacteremia and septicaemia [35-37]. Phylogenetic studies examining the relationship between plant and clinical isolates have shown that they are indistinguishable, making their potential pathogenicity in plant and animal hosts unclear [38]. …”

Section: Plant Pathogens That Infect Humansmentioning

confidence: 99%

Insights into Cross-Kingdom Plant Pathogenic Bacteria

Kirzinger

Nadarasah

Stavrinides

2011

Genes

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Plant and human pathogens have evolved disease factors to successfully exploit their respective hosts. Phytopathogens utilize specific determinants that help to breach reinforced cell walls and manipulate plant physiology to facilitate the disease process, while human pathogens use determinants for exploiting mammalian physiology and overcoming highly developed adaptive immune responses. Emerging research, however, has highlighted the ability of seemingly dedicated human pathogens to cause plant disease, and specialized plant pathogens to cause human disease. Such microbes represent interesting systems for studying the evolution of cross-kingdom pathogenicity, and the benefits and tradeoffs of exploiting multiple hosts with drastically different morphologies and physiologies. This review will explore cross-kingdom pathogenicity, where plants and humans are common hosts. We illustrate that while cross-kingdom pathogenicity appears to be maintained, the directionality of host association (plant to human, or human to plant) is difficult to determine. Cross-kingdom human pathogens, and their potential plant reservoirs, have important implications for the emergence of infectious diseases.

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“…Strains of Pantoea are also opportunistic, and have been isolated from human skin abrasions and bodily fluids such as blood and urine, and have even been implicated in several nosocomial outbreaks (De Champs et al 2000;Bicudo et al 2007;Cruz et al 2007;Duan et al 2007;Aly et al 2008;Brady et al 2008;Rezzonico et al 2009;Volksch et al 2009;Lalas and Erichsen 2010). Human infections have been reported to result from penetrative injury from infected plants, often by cuts and scrapes from thorns and splinters (Flatauer and Khan 1978;De Champs et al 2000;Kratz et al 2003;Cruz et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Inheritance of Pantoea type III secretion systems through both vertical and horizontal transfer

2015

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The type III secretion system (T3SS) is an extracellular apparatus used by many Gram-negative bacteria to deliver effector proteins directly into plant and animal cells, thereby facilitating host-specific association. Strains of the enterobacterial genus, Pantoea, have been isolated from a wide variety of hosts, including plants, insects, and humans, yet it is unclear whether the T3SS may be involved in these associations. In this study, we use comparative genomics and phylogenetic methods to examine the origin and distribution of T3SSs in 35 sequenced environmental and clinical strains of Pantoea. We began our analysis by examining the distribution of the previously characterized plant cell-specific PSI-1 and animal cell-specific PSI-2 of the plant pathogenic Pantoea stewartii subsp. stewartii DC283 (PstDC283), and showed that both had a somewhat limited distribution. Our analysis, however, identified two variants of a unique plant cell-specific T3SS (PSI-1a and PSI-1b) in six Pantoea strains, including a clinical isolate. Our genome analysis of PstDC283 also identified a third T3SS that we named PSI-3, which has a similar genetic content and organization to the Salmonella, animal cell-specific SPI-2 system. Phylogenetic analysis of all three systems suggests that the PSI-1 system has been inherited vertically, whereas the newly identified PSI-1a and PSI-1b systems have been acquired independently from other genera within the Enterobacteriaceae. PSI-2 appears to have been acquired horizontally as far back as the Erwinia/Pantoea common ancestor, with evidence of more recent horizontal acquisition of the PSI-3 system. Our results suggest that Pantoea is a relatively old plant pathogen that has lost and subsequently regained different plant-associated T3SSs. This work has broad implications for understanding the host-associating capacity of Pantoea strains, and reveals the propensity for Pantoea isolates to exchange pathogenicity determinants with human-pathogenic members of the Enterobacteriaceae.

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Polyphasic study of plant- and clinic-associated Pantoea agglomerans strains reveals indistinguishable virulence potential

Cited by 49 publications

References 49 publications

Novel plant growth promoting rhizobacteria—Prospects and potential

Novel plant growth promoting rhizobacteria—Prospects and potential

Insights into Cross-Kingdom Plant Pathogenic Bacteria

Inheritance of Pantoea type III secretion systems through both vertical and horizontal transfer

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