Polyphenol-functionalized hydrogels using an interpenetrating chitosan network and investigation of their antioxidant activity

Kim, Boram; Kang, Bo Sun; Vales, Temmy Pegarro; Yang, Si Kyung; Lee, Joomin; Kim, Ho‐Joong

doi:10.1007/s13233-018-6001-8

Cited by 27 publications

(12 citation statements)

References 25 publications

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“…Notably, the miscibility of the monomers is a major criterion which governs the overall transmittance of the resultant hydrogels. It is well‐known that the immiscibility of each component results in opaque or phase‐separated hydrogels . Hence, the good percentage transmittance obtained for the copolymer hydrogels indicates that the copolymerization strategy provides homogeneous incorporation of MPC polymers on the p(HEMA)‐hydrogel.…”

Section: Resultsmentioning

confidence: 99%

Protein Adsorption and Bacterial Adhesion Resistance of Cross‐linked Copolymer Hydrogels Based on Poly(2‐methacryloyloxyethyl phosphorylcholine) and Poly(2‐hydroxyethyl methacrylate)

Vales

Jee

Lee

et al. 2020

Bulletin Korean Chem Soc

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Herein, the preparation of the cross-linked copolymer hydrogels composed of various weight ratios of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 2-hydroxyethyl methacrylate (HEMA) monomers employing free-radical polymerization was reported. The integration of the MPC monomer into HEMAbased hydrogels showed good transmittance (>90%) and enhanced the water content retention (79-202%) relative to those of pure HEMA-based hydrogel. Notably, the MPC-containing hydrogels (MPC-H) exhibited the improved anti-biofouling properties due to the formation of a compact hydration layer produced by the biomimetic MPC units at the hydrogel surface. MPC-H exhibited a decrease in the bovine serum albumin (BSA) and lysozyme adsorption of approximately 40-70% and 44-65%, respectively, relative to those of control hydrogel without MPC monomer. The results presented herein demonstrate the potential of expending biocompatible monomers such as HEMA and MPC to efficiently generate a biomaterial that possesses both bio-membrane mimicking character and protein and bacterial resistant properties for various industrial and biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Protein Adsorption and Bacterial Adhesion Resistance of Cross‐linked Copolymer Hydrogels Based on Poly(2‐methacryloyloxyethyl phosphorylcholine) and Poly(2‐hydroxyethyl methacrylate)

Vales

Jee

Lee

et al. 2020

Bulletin Korean Chem Soc

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“…Polyphenol-modified (gallic acid and dopamine) chitosan hydrogels were also prepared by Kim and colleagues [74,75]. The resulting antioxidant capacity was stronger in the GA-functionalized hydrogels, supposedly because of the higher number of hydroxylic groups, and in the hydrogels prepared with longer chitosan chains, probably because of the higher number of conjugable polyphenols.…”

Section: Polymeric Formulationsmentioning

confidence: 99%

Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations

et al. 2019

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Reactive oxygen and nitrogen species (RONS) are produced endogenously in our body, or introduced through external factors, such as pollution, cigarette smoke, and excessive sunlight exposure. In normal conditions, there is a physiological balance between pro-oxidant species and antioxidant molecules that are able to counteract the detrimental effect of the former. Nevertheless, when this homeostasis is disrupted, the resulting oxidative stress can lead to several pathological conditions, from inflammation to cancer and neurodegenerative diseases. In this review, we report on the recent developments of different polymeric formulations that are able to reduce the oxidative stress, from natural extracts, to films and hydrogels, and finally to nanoparticles (NPs).

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“…Significant interest has emerged in the development and design of functional biomaterials with excellent biocompatibility and antibiofouling properties. A promising biomaterial that has long been investigated for diverse biomedical and industrial applications is the hydrogel, which consists of three-dimensional cross-linked hydrophilic polymeric networks capable of retaining large amounts of water and biological fluids [1,2]. Parhi has comprehensively reviewed the different types of cross-linking-based hydrogels for various pharmaceutical applications including small-molecule cross-linked hydrogels, polymer-polymer cross-linked hydrogels, photo cross-linked hydrogels, enzymatic cross-linked hydrogels, and interpenetrating networks [3].…”

Section: Introductionmentioning

confidence: 99%

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption

et al. 2020

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A series of hydrogels with intrinsic antifouling properties was prepared via surface-functionalization of poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based hydrogels with the biomembrane-mimicking zwitterionic polymer, poly(2-methacryloyloxyethyl phosphorylcholine) [p(MPC)]. The p(MPC)-modified hydrogels have enhanced surface wettability, high water content retention (61.0%–68.3%), and good transmittance (>90%). Notably, the presence of zwitterionic MPC moieties at the hydrogel surfaces lowered the adsorption of proteins such as lysozyme and bovine serum albumin (BSA) by 73%–74% and 59%–66%, respectively, and reduced bacterial adsorption by approximately 10%–73% relative to the unmodified control. The anti-biofouling properties of the p(MPC)-functionalized hydrogels are largely attributed to the dense hydration layer formed at the hydrogel surfaces by the zwitterionic moieties. Overall, the results demonstrate that biocompatible and antifouling hydrogels based on p(HEMA)-p(MPC) structures have promising potential for application in biomedical materials.

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Polyphenol-functionalized hydrogels using an interpenetrating chitosan network and investigation of their antioxidant activity

Cited by 27 publications

References 25 publications

Protein Adsorption and Bacterial Adhesion Resistance of Cross‐linked Copolymer Hydrogels Based on Poly(2‐methacryloyloxyethyl phosphorylcholine) and Poly(2‐hydroxyethyl methacrylate)

Protein Adsorption and Bacterial Adhesion Resistance of Cross‐linked Copolymer Hydrogels Based on Poly(2‐methacryloyloxyethyl phosphorylcholine) and Poly(2‐hydroxyethyl methacrylate)

Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption

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