Polyphenol-rich green tea extract induces thermogenesis in mice by a mechanism dependent on adiponectin signaling

Bolin, Anaysa Paola; Sousa-Filho, Celso Pereira Batista; Marinovic, Marcelo Paradiso; Rodrigues, Alice Cristina; Otton, Rosemari

doi:10.1016/j.jnutbio.2019.108322

Cited by 21 publications

(24 citation statements)

References 45 publications

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“…Global effects of flavanols in adipose tissues lead to a decrease in adiposity, specially of the WAT depots and in adipocyte size by reducing adipogenesis, the release of adipokines such as leptin and resistin, the modulation of lipid metabolism and the induction of browning [ 153 , 155 , 158 , 169 , 170 , 171 , 172 , 173 , 174 ]. In BAT, flavanols caused the activation of thermogenesis and FAO [ 172 , 173 , 174 , 175 , 176 ].…”

Section: Flavanolsmentioning

confidence: 99%

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Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Flavanolsmentioning

confidence: 99%

“…The treatment with this extract reversed part of the obesity phenotype in WT mice but no in adiponectin KO mice (AdipoKO). PGTE treatment increased EE, BAT thermogenesis, and promoted browning phenotype in the scWAT of WT mice but these effects were blunted in AdipoKO mice [ 176 ].…”

Section: Flavanolsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…78 Green tea (GT), which is rich in polyphenols, promotes BAT heat production by increasing adiponectin levels and activates AMPKa1 to promote lipid decomposition through PKA-HSL. 79 6-Gingerol can relieve ectopic lipid accumulation in the skeletal muscle of aging rats by increasing the level of adiponectin and its receptor, activating AdipoR1, and downstream AMPK/ PGC1α signaling. 80 Huganqingzhi tablets (HQTs) can increase adiponectin levels, activate AMPK and PPARα pathways to inhibit SREBP-1 in the liver and de novo fat production, promote β-oxidation of fatty acids, and decrease cellular lipid levels.…”

Section: Enhance Leptin Sensitivitymentioning

confidence: 99%

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Li¹,

Zhang²,

Li³

2020

DMSO

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Obesity is the lipid deposition caused by the imbalance between energy intake and consumption caused by a variety of factors. Obesity can lead to multiple systemic complications. At present, the treatment of obesity is mainly lifestyle intervention, drug weight loss, and weight loss surgery, but the curative effect is limited or the side effects are serious. Traditional Chinese medicine plays a unique role in the treatment of obesity. Existing studies have found that traditional Chinese medicine can treat obesity in a variety of ways, such as regulating intestinal microflora, enhancing hormone level, regulating fat metabolism, and so on. In this review, we will introduce and summarize the mechanism of traditional Chinese medicine in the treatment of obesity.

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“…These metabolically active cells generate from WAT cells primarily through beta-adrenergic receptor activation in an autocrine, paracrine, or endocrine mechanism when exposed to cold or food ingredients [ 20 , 22 , 23 ]. The browning of WAT requires the active involvement of several metabolic factors that include adiponectin [ 12 , 13 , 24 ] and triiodothyronine (T3) [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

et al. 2020

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Background: LI85008F is a proprietary combination of leaf extracts of Moringa oleifera, Murraya koeingii, and extract of Curcuma longa rhizome. This herbal extract combination is an effective weight loss supplement for overweight and obese subjects. The present study aimed to investigate the thermogenic potential of the LI85008F in high-fat diet (HFD)-induced obese Sprague Dawley rats. Methods: Seven rats received a regular diet (RD), and twenty-one rats received a high-fat diet (HFD) for 56 days. On day 28, the HFD-fed rats were randomized into three groups (n = 7). Starting from day 29 through day 56, one HFD-fed group received daily oral gavage of 0.5% Carboxymethylcellulose Sodium (CMC) alone (HFD), and the remaining two groups received 100 and 250 mg/kg LI85008F (LI85008F-100 and LI85008F-250, respectively). Body weight, fat mass, fat cell size, liver weight, liver triglyceride were measured. The energy metabolism parameters were measured using indirect calorimetry. In serum, the metabolic and endocrine markers were analyzed. The adipogenic and thermoregulatory proteins expression in the white adipose tissue (WAT) were analyzed using an immunoblot assay. Results: Supplementation with both doses of LI85008F significantly increased resting energy expenditure (REE) in the obese rats. The LI85008F-250 rats showed significant up-regulation of uncoupling protein-1 (UCP-1) expression, as compared with the HFD rats. LI85008F significantly reduced body weight gain, fat mass, fat cell size, liver weight, and hepatic triglycerides. Serum triglyceride, total cholesterol, glucose, leptin, and fat cell markers were significantly reduced in LI85008F-supplemented rats compared to the HFD rats. Conclusion: The present data suggest that LI85008F reduces body fat mass and controls body weight gain via increasing energy metabolism in combination with reduced lipogenesis in diet-fed obese rats.

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Polyphenol-rich green tea extract induces thermogenesis in mice by a mechanism dependent on adiponectin signaling

Cited by 21 publications

References 45 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

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