Polyphenolic Compounds of Sideritis lycia and Their Anti-Inflammatory Activity

Phenolic compounds of Sideritis ozturkii and their in vivo anti-inflammatory and antinociceptive activities

“…Sideritis species growing in Turkey are known to be rich in essential oils Baser, 2002), diterpenes (Topçu et al, 2002;Sahin et al, 2004Sahin et al, , 2005, flavonoids and phenylethanoid glycosides (Ezer et al, 1992a;Akcoş et al, 1999;Sahin et al, 2004Sahin et al, , 2005. In a continuation of our phytochemical studies on Turkish Sideritis species, we now report the isolation of phenolic compounds from Sideritis ozturkii Aytaç & Aksoy, which is endemic to Turkey, through in vivo bioassayguided fractionation procedures.…”

“…In our previous studies, in addition to phenylethanoid glycosides and flavonoids which were isolated from various Sideritis species and investigated for their effects on gastric ulceration and anti-inflammatory activity (Akcoş et al, 1999), iridoids and essential oils were investigated for their antimicrobial activity (Akcoş et al, 1998;Ezer and Abbasoglu, 1996). We also confirmed diuretic, anti-inflammatory (Yeşilada and Ezer, 1989), antispasmodic (Ezer et al, 1992b), antibacterial (Ezer et al, 1994) and antioxidant activities (Güvenç et al, 2005) of different extracts from several Sideritis species growing in Turkey.…”

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

“…[45]. Carrageenan-induced mouse paw edema test has been employed to identify PhGs from Sideritis lycia as potential anti-inflammatory agents with less side effects such as gastric ulceration [217]. Lin et al reported that acteoside, crenatoside, and rossicaside B could inhibit ROS production (likely through modulation of NADPH oxidase activity and/or the radical scavenging effect) and β2 integrin expression in leukocytes, indicating that these PhGs can serve as potential anti-inflammatory agents during oxidative stress [218].…”

High Levels of Genetic Variation as Detected by Aflp in Sideritis tmolea from Western Turkey

“…There are a number of studies of the pharmaceutical compounds in Sideritis species and these studies especially have focused on essential oils, diterpenes and flavonoids (Akcos et al, 1999;Kirimer et al, 2001;Topcu et al, 2002). Various anti-inflammatory, analgesic, diuretical, antiulcer, antidepressant, antimicrobial and insect repellent effects of Sideritis species that are grown in Turkey have been studied (Ozturk et al, 1996;Akcos et al, 1999;Bondi et al, 2000).…”

“…Various anti-inflammatory, analgesic, diuretical, antiulcer, antidepressant, antimicrobial and insect repellent effects of Sideritis species that are grown in Turkey have been studied (Ozturk et al, 1996;Akcos et al, 1999;Bondi et al, 2000). Sideritis species have an important place among other plants both as an herbal tea and household remedy.…”