Polyphenolic content and biochemical evaluation of fijk, alomo, osomo and oroki herbal mixtures in vitro

Adeyemi, Oluyomi Stephen; Owoseni, M.C.

doi:10.1016/j.bjbas.2015.07.002

Cited by 3 publications

(9 citation statements)

References 20 publications

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“…However, recent studies have demonstrated the need to subject some of the herbal preparations through a scientific validation process to ascertain their health benefits [7,8]. Therefore, this study was designed to evaluate the antioxidant and anti-inflammatory properties of the abovementioned polyherbal preparation: Oroki herbal, Swedish bitters and Yoyo bitters with the rationale to proffer a scientific explanation for the local use of these formulations.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of selected polyherbal preparations: Oroki herbal, Swedish bitters and Yoyo bitters

Anyasor¹,

Ogunbiyi²,

Akinlusi³

2017

Oxid Antioxid Med Sci

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Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of selected polyherbal preparations: Oroki herbal, Swedish bitters and Yoyo bitters

Anyasor¹,

Ogunbiyi²,

Akinlusi³

2017

Oxid Antioxid Med Sci

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“…[8]; Imaga and Valentine [12]; Adeyemi and Owoseni [22] on some of these polyherbal drugs (Swedish bitters, Yoyo bitters and Oroki herbal mixtures).…”

Section: Discussionmentioning

confidence: 99%

“…cirrhosis. Adeyemi and Owoseni [22], Adeyemi et al [8], Imaga and Valentine [12] and Gafrikova et al [24] all stated oxidative damage of biomolecules to be one of the dangerous effects of depleted antioxidant enzymes as a result of overproduction of free radicals among other dangers.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the decrease in GSH concentrations; a naturally occurring antioxidant that prevents free radical damaged of cells and as well helps in detoxification process by conjugating with chemicals/ oxidants [22], must have resulted from the free radical scavenging activity of GST. GST is an antioxidant enzyme that uses GSH as cofactor in its defense mechanism to prevent oxidative damage just like glutathione peroxidase (GPx) and glutathione reductase (GR).…”

Section: Discussionmentioning

confidence: 99%

“…GST (µmol/ml/min) 34 22. ± 27.71 a 21.02 ± 2.51 b 18.40 ± 2.69 b 24.35 ± 8.16 ab 28.76 ± 3.06 ab 31.76 ± 2.94 ab 24.87 ± 2.22 ab 27.17 ± 2.35 ab 28.73 ± 0.53 ab…”

mentioning

confidence: 99%

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Depletion of Hepatic Antioxidant Enzymes in Experimental Albino Rats Due to Polyherbal Medicines Administration

Emaleku¹

2018

J Stem Cell Res Ther

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Objective: Plants and their derived products have served as veritable sources of foods and medicines for humans and animals from the outset, and the emergency of polyherbs (plants-derived products) in recent years has received the widest publicity and patronage by the Nigerian population as alternative medicines. It is not over statement to say many of them lack empirical data or validation to support the upsurge and prevalence in their usage as folk medicines, and little or no scientific data exist on their potential side effects. This study therefore investigates "the effects of some of these polyherbal drugs on hepatic antioxidants in experimental rats". Methods: Eight of the nine groups containing five animals each used for this study were administered eight different polyherbal drugs following different manufacturer's recommended dosage, while the ninth group served as control with no polyherb treatment. The study lasted for seven weeks i.e. forty-nine days, and on the 50th day, the animals were sacrificed after 12 h of previous overnight fasting, and their livers were excised for antioxidant assays. Results: Fidson bitters and Asheitu Adams blood purifier (ABP) significantly decreased superoxide oxidase (SOD) and glutathione-S-transferase (GST), while Yoyo bitter and Asheitu Adams formula for diabetes (AD) mostly decreased reduced glutathione (GSH) in a non-significant manner at (p<0.05). Conclusion: All polyherbal medicines caused depletion of hepatic antioxidant enzymes (SOD and GST), which is an indication of oxidative stress condition, but some of them improved non-enzymatic antioxidants like malondialdehyde (MDA) and vitamin C.

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Potential Hematotoxicity and Genotoxicity of Multi-Herbal Formulations in Albino Mice (Mus musculus)

Kehinde

Adebayo

Adesiyan

et al. 2020

Preprint

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The current increase in the use of multi-herbal remedies coupled with loose regulation on public access to these products underscore research efforts to evaluate their biochemical effect, noting that many of the herbal medicines lack scientific evidence to support their medicinal claims. Objective: We therefore investigated the potential genotoxicity and hematotoxicity of commonly consumed multi-herbal formulations (YoyoBitters, Ogidiga and BabyOku) in Lagos, Nigeria, in experimental mice. Methods: Fifty (50) adult female albino mice were randomly selected and distributed into 5 groups of 10 mice each. Two mL/kg body weight of distilled water were orally administered to the control groups while BabyOku, YoyoBitters and Ogidiga herbal formulations were administered to the experimental groups at doses of 2 mL/kg body weights. Results: A dose- and tissue-dependent increase in induction of apoptotic DNA fragmentation was observed in the triherbal groups relative to control groups. Also, an increase in micronucleated polychromatic erythrocytes was formed in a dose-dependent manner in the multi-herbal groups when compared with the control groups. Conclusion: From our findings, multi-herbal formulations may possess hematotoxic and genotoxic potentials in mice.

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Polyphenolic content and biochemical evaluation of fijk, alomo, osomo and oroki herbal mixtures in vitro

Cited by 3 publications

References 20 publications

Antioxidant and anti-inflammatory properties of selected polyherbal preparations: Oroki herbal, Swedish bitters and Yoyo bitters

Antioxidant and anti-inflammatory properties of selected polyherbal preparations: Oroki herbal, Swedish bitters and Yoyo bitters

Depletion of Hepatic Antioxidant Enzymes in Experimental Albino Rats Due to Polyherbal Medicines Administration

Potential Hematotoxicity and Genotoxicity of Multi-Herbal Formulations in Albino Mice (Mus musculus)

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