Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats

Akter, Noushin; Chowdhury, Farzana; Selim, Saima; Nayan, Shariful Islam; Khan, Ferdous; Subhan, Nusrat; Hossain, Hemayet; Rahman, Mizanur; Haque, Md. Areeful; Alam, Muhammad Ashraful

doi:10.1016/j.jff.2020.104250

Cited by 8 publications

(22 citation statements)

References 52 publications

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“…The presence of thiobarbituric acid reactive substances (TBARS) in renal tissues was measured as a lipid peroxidation parameter according to a method described earlier [ 26 , 27 ]. In short, tissue homogenate (0.1 mL) which are present in Tris-HCl buffer, pH 7.5, was mixed with 2 mL of TBA-TCA-HCl reagent.…”

Section: Methodsmentioning

confidence: 99%

“…In this experimental analysis, naphthyl ethylene diaminedihydrochloride (0.1% w/v) was used in lieu of 1-napthylamine (5%) to increase the solubility in aqueous system. This method is also described in details in our previous articles [ 26 , 27 ]. Kidney homogenate (2 mL) was incubated with Griess-Illosvoy reagent and phosphate buffered saline (0.5 mL) at 25 °C.…”

Section: Methodsmentioning

confidence: 99%

“…The absorbance of the supernatant was taken at 540 nm against the blank solution. NO level of tissue (nmol/g tissue) was calculated by using a calibration curve [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

“…APOP concentration was also determined in kidney tissues followed by a previously established protocol [ 26 , 27 ]. At first, plasma samples (2 mL) were diluted in phosphate buffer saline at 1:5 ratios.…”

Section: Methodsmentioning

confidence: 99%

“…The final concentration of APOP present in the tissue homogenates was calculated as nmol·mL −1 chloramine-T equivalents. A chloramine-T standard curve was established using the concentration range 0–100 nmol/mL which showed a linear relationship [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

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Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats

Selim

Akter

Nayan

et al. 2021

Biochemistry and Biophysics Reports

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This study evaluated the effect of Flacourtia indica fruit extract against isoprenaline (ISO) induced renal damage in rats. This investigation showed that ISO administration in rats increased the level oxidative stress biomarkers such as malondialdehyde (MDA), nitric oxide (NO), advanced protein oxidation product (APOP) in kidneys followed by a decrease in antioxidant enzymes functions. Flacourtia indica fruit extract, which is rich in strong antioxidants, also reduced the MDA, NO and APOP level in kidney of ISO administered rats. Inflammation and necrosis was also visible in kidney section of ISO administered rats which was significantly prevented by atenolol and Flacourtia indica fruit extract. Moreover, atenolol and Flacourtia indica fruit extract also modulated the genes expressions related to inflammation and oxidative stress in kidneys. The beneficial effects could be attributed to the presence of a number of phenolic antioxidants. This study suggests that Flacourtia indica fruit extract may prevent kidney dysfunction in ISO administered rats, probably by preventing oxidative stress and inflammation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The absorbance of the supernatant was taken at 540 nm against the blank solution. NO level of tissue (nmol/g tissue) was calculated by using a calibration curve [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats

Selim

Akter

Nayan

et al. 2021

Biochemistry and Biophysics Reports

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Polyphenol-rich leaf of Aphanamixis polystachya averts liver inflammation, fibrogenesis and oxidative stress in ovariectomized Long-Evans rats

Rahman

Shahab

Miah

et al. 2021

Biomedicine & Pharmacotherapy

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Antioxidative role of palm grass rhizome ameliorates anxiety and depression in experimental rodents and computer-aided model

Hoque

Ahmad

Chakrabarty

et al. 2021

Heliyon

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Palm grass (Curculigo recurvata) is an ethnomedicinally important herb reported to have significant medicinal values. The present study aimed to evaluate the antidepressant and anxiolytic activities of a methanol extract of C. recurvata rhizome (Me-RCR) through different approaches. The antidepressant and anxiolytic properties of Me-RCR were assessed by using elevated plus maze (EPM), hole-board (HBT), tail suspension (TST), and forced swimming (FST) tests in Swiss Albino mice. The in-depth antioxidative potential of Me-RCR was also evaluated through DPPH radical scavenging activity, ferric-reducing power capacity, total phenolic, flavonoid, flavonol, and antioxidant content analysis. Computational investigations were performed using computer-aided methods for screening the anxiolytic, antidepressant, and antioxidative activities of the selected lead molecules. Treatment with Me-RCR (200 and 400 mg/kg, b.w.) notably increased the number of open arm entries and the time spent in the EPM test. In the HBT, Me-RCR exhibited significant anxiolytic activity at a dose of 200 mg/kg, whereas similar activity was observed at 400 mg/kg in the EPM test. Me-RCR significantly decreased the immobility time in a dose-dependent manner in both TST and FST. The IC 50 for DPPH and reducing power capacity assay were found

show abstract

Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats

Cited by 8 publications

References 52 publications

Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats

Flacourtia indica fruit extract modulated antioxidant gene expression, prevented oxidative stress and ameliorated kidney dysfunction in isoprenaline administered rats

Polyphenol-rich leaf of Aphanamixis polystachya averts liver inflammation, fibrogenesis and oxidative stress in ovariectomized Long-Evans rats

Antioxidative role of palm grass rhizome ameliorates anxiety and depression in experimental rodents and computer-aided model

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