Polyphenols against infectious diseases: Controlled release nano-formulations

Murthy, Namratha Turuvekere Vittala; Agrahari, Vibhuti; Chauhan, Harsh

doi:10.1016/j.ejpb.2021.02.003

Cited by 31 publications

(21 citation statements)

References 121 publications

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“…Additionally, naturally occurring polyphenols aid in the fight against the emergence of infections that are resistant to many drugs (Turuvekere Vittala Murthy et al, 2021). Gallic acid is a component of pharmaceuticals that have antioxidant, anticancer, antibacterial, chondro-protective, carbonic anhydrase inhibitor, antidiabetic, anti-ulcerogenic, and anti-inflammatory properties (Al Zahrani et al, 2020).…”

Section: P Olyphenol S and Their Char Ac Teris Tic Smentioning

confidence: 99%

Starch, gallic acid, their inclusion complex and their effects in diabetes and other diseases—A review

Nag

Majumder

2022

Food Science & Nutrition

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Starch is the most important energy‐providing component of food. It is useful for maintaining the structural and rheological consistency of food, ad thus, in turn, is responsible for maintaining the freshness of food. Polyphenols are present in plant products in huge amounts as secondary metabolites. Gallic acid, one of the potent plant polyphenols, has been reported to have excellent anti‐inflammatory, antioxidative, anticarcinogenic, microbicidal, and antidiabetic properties. Till date, very few articles on the starch–polyphenol inclusion complex are present. Quite a few hypotheses have been proposed as to how the formation of an inclusion complex of starch with polyphenol can slower the digestion or the hydrolysis of starch. The efficient qualities of starch–polyphenol systems, such as reduced starch digestion, lower blood glucose and preserving food freshness, have formed a necessity for investigation in this area. The focus of this review centers on the recent research on starch–polyphenol interactions and starch–gallic acid inclusion complexes in native and extruded food systems, as well as how the production of these complexes can aid in the treatment of diseases, particularly diabetes mellitus.

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Section: P Olyphenol S and Their Char Ac Teris Tic Smentioning

confidence: 99%

Starch, gallic acid, their inclusion complex and their effects in diabetes and other diseases—A review

Nag

Majumder

2022

Food Science & Nutrition

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“…NFs are produced after the evaporation of solvent which is used by exposing high electrical voltage in this technique. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

“…NFs are produced after the evaporation of solvent which is used by exposing high electrical voltage in this technique. [11] PLA is a biodegradable, biocompatible, bioabsorbable, hydrophobic, synthetic, and semicrystalline aliphatic polymer. PLA, which has three isomeric forms ((d), (l), and racemic (d,l)), is a semicrystalline solid that has been approved by the Food and Drug Administration (FDA) for biomedical usage.…”

Section: Introductionmentioning

confidence: 99%

“…[10] Since it is very crucial to design an appropriate drug delivery system with a controlled release capability, controlled drug release from NFs has gained importance in the development of new methods to increase biosolubility and bioavailability by decreasing the amount of drug administered. [11,12] Electrospinning (ES), an electro-hydrodynamic atomization method that can be used for scale production of nanofibers in industrial applications, is used to create ultrafine fibers using an electrostatic potential characterized by high voltage and very low current. [13,14] ES is widely used to produce polymeric NFs in different diameters by changing solution properties and process control parameters.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin‐Loaded Polycaprolactone/Polylactic Acid Nanofibers

Aydın

Kabaoglu

Güler

et al. 2022

Macro Materials & Eng

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Nanofibers (NFs) offer an alternative option for the treatment of Alzheimer's disease (AD) by addressing unmet clinical problems. In this study, anti‐AD drugs, donepezil (DO) and curcumin (CUR), are loaded in polylactic acid/polycaprolactone NFs. The effect of fiber diameter on drug release behavior is mainly observed, and the successful loading of DO and CUR to NFs is demonstrated. The tensile strength of DO/CUR‐loaded NFs (DNFs) with lower fiber diameter is found to be higher. The working temperature is increased by the decrease of glass transition temperature and increase of the melting temperature after loading drugs. Furthermore, the increase in the percentage of swelling and decrease in the degradation rate for NFs are observed due to the increase of fiber diameter. Encapsulation efficiency and burst release percentages for DNFs are augmented by the increase of fiber diameter. Nevertheless, DNFs exhibit a sustained drug release manner over 2 weeks. NFs do not demonstrate a toxic effect on L929 (mouse fibroblast) cells, and additionally, they promote cell proliferation. Considering all these results, it is proven that the fiber diameter affects all characteristic features of NFs, and DNFs lead to a new and promising drug delivery system for the treatment of AD.

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Toxicity of Polyphenols Consumed as Food and Nutraceuticals

Gabriel,

Chinenye

2023

Polyphenols

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Polyphenols against infectious diseases: Controlled release nano-formulations

Cited by 31 publications

References 121 publications

Starch, gallic acid, their inclusion complex and their effects in diabetes and other diseases—A review

Starch, gallic acid, their inclusion complex and their effects in diabetes and other diseases—A review

A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin‐Loaded Polycaprolactone/Polylactic Acid Nanofibers

Toxicity of Polyphenols Consumed as Food and Nutraceuticals

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