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: Polyphenols comprises of a large group of naturally occurring plant secondary metabolites having various nutritional and health benefits. They are safe and are found abundantly in the diet. Current research on polyphenols focuses on their mechanism and their benefits on the human health. However, due to their low solubility and bioavailability, delivery from conventional route has been a challenge and their translation into clinical applications has been limited. Topical and transdermal delivery of polymeric nanoparticles will act as a novel therapeutic approach for promising delivery of polyphenols. In this review, we have evaluated the existing scientific literature and summarized the potential use of polymeric nanoparticles as a carrier for polyphenolic compounds for delivery via topical and transdermal routes for the treatment of skin cancers such as melanoma.

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