Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention

Abstract

Background Liver cancer is one of the common malignancies. The dysregulation of metabolism is a driver of accelerated tumourigenesis. Metabolic changes are well documented to maintain tumour growth, proliferation and survival. Recently, a variety of polyphenols have been shown to have a crucial role both in liver disease prevention and metabolism regulation. Methods We conducted a literature search and combined recent data with systematic analysis to comprehensively describe the molecular mechanisms that link polyphenols to metabolic regulation and their contribution in liver protection and liver cancer prevention. Results Targeting metabolic dysregulation in organisms prevents and resists the development of liver cancer, which has important implications for identifying new therapeutic strategies for the management and treatment of cancer. Polyphenols are a class of complex compounds composed of multiple phenolic hydroxyl groups and are the main active ingredients of many natural plants. They mediate a broad spectrum of biological and pharmacological functions containing complex lipid metabolism, glucose metabolism, iron metabolism, intestinal flora imbalance, as well as the direct interaction of their metabolites with key cell‐signalling proteins. A large number of studies have found that polyphenols affect the metabolism of organisms by interfering with a variety of intracellular signals, thereby protecting the liver and reducing the risk of liver cancer. Conclusion This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.

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Possible Side Effects of Polyphenols and Their Interactions with Medicines

“…Polyphenols are also important anti-cancer agents [ 79 ]. Tea polyphenol compounds were proven in many animal models to prevent various types of cancers, e.g., ovarian, breast, pancreas, colorectal, oesophagus, liver, lung, and kidney cancers [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ]. Moreover, in vitro studies have demonstrated that the anticancer activity of polyphenols relies on their ability to inhibit growth or stimulate apoptosis in various cancer cell lines, such as HL60 human promyelocytic leukaemia cells, A431 epidermoid carcinoma cells, LNCaP and androgen-insensitive PC-3 human prostate carcinoma cells, human prostate cancer LNCaP cells, OVCA 433 human ovarian cancer, HepG2 cells, Caco-2 human colon cancer cells, human pancreatic carcinoma cell line Mia PACA-2, and oestrogen-independent MDA-MB-435 and oestrogen-dependent MCF-7 breast cancer cell lines [ 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ].…”