Polyphenols from brown alga, <i>Padina boergesenii</i> (Allendar &amp; Kraft) decelerates renal cancer growth involving cell cycle arrest and induction of apoptosis in renal carcinoma cells

Karthikeyan, R.; Thirugnanasambandan, Somasundaram S.

doi:10.1002/tox.22619

Cited by 14 publications

(9 citation statements)

References 33 publications

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“…The recent studies have shown the significant contribution of phenolic compounds in cardiovascular and cancer prevention and assume their important role in the neurodegenerative and diabetes mellitus prevention [ 12 , 13 ]. Brown algae polyphenols are also found to have a hepatoprotective [ 14 , 15 ] and antitumor activity [ 16 ]. The brown algae phlorotannins demonstrate an anti-inflammatory effect [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Polyphenolic Content in Brown Algae of the Pacific Coast of Russia

et al. 2020

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Water and ethanol brown macroalgal extracts of nine species of Laminariales and four species of Fucales of the Pacific coast of Russia were investigated. It has been shown that brown algae species of Agarum, Thalassiophyllum, Fucus and Cystoseira can be a source of the polyphenolic compounds with antioxidant activity. Phenolic content in the ethanol algal extracts (Undaria pinnatifida, Arthrothamnus bifidus, Thalassiophyllum clathrus and Agarum turneri) was 1.1–3.5 times higher than in the water extracts. In Sargassum pallidum and Kjellmaniella crassifolia, the total polyphenolic content was 2.1 and 1.6 times higher, respectively, in water extracts than in ethanol extracts. The maximum radical scavenging activity has been detected in Agarum turneri ethanol extracts (38.8 mg ascorbic acid/g and 2506.8 µmol Trolox equiv/g dry algae). Phlorotannin content varies from 16.8 μg/g dry sample of Costaria costata to 2763.2 μg/g dry sample of Agarum turneri. It is found the content of polyphenolic compounds in brown algae is determined mainly by their species-specificity and by their belonging to the genus. The presence of major phenols in the extract of Thalassiophyllum clathrus, such as phenolic acid (gallic acid), hydroxycinnamic acids (caffeic acid, chlorogenic acid, coumaric acid) and flavonols (kaempferol, quercetin) has been established.

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Section: Introductionmentioning

confidence: 99%

Characteristics of Polyphenolic Content in Brown Algae of the Pacific Coast of Russia

et al. 2020

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“…There is consensus that polyphenols act as anti-cancer agents by reducing cell growth, arresting cell cycle and inducing apoptosis ( Rajamani 2018 ; Chaves et al, 2020 ; Dyshlovoy et al, 2020 ). In a previous work, our group showed that YMe, which contains a complex mixture of phytochemicals, reduces cell growth and induces apoptosis due to an activation of the intrinsic pathway in a colorectal cancer model.…”

Section: Discussionmentioning

confidence: 99%

Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models

et al. 2021

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Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.

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“…In contrast, compounds in coffee (i.e., flavanones) reduce tumor formation via the VHL pathway [41]. Phenolic acids and diterpenes found in coffee have been reported as potent inhibitors of cancer proliferation via the induction of apoptosis [32,34,30].…”

Section: Discussionmentioning

confidence: 99%

Coffee intake and trace element blood concentrations in association with renal cell cancer among smokers

Weinstein

Moore

et al. 2021

Cancer Causes Control

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Purpose: Determine whether higher coffee intake may reduce the risk of renal cell cancer (RCC) associated with lead (Pb) and other heavy metals with known renal toxicity. Methods: We conducted a nested case-control study of male smokers (136 RCC cases and 304 controls) within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Cases diagnosed with RCC at five or more years following cohort enrollment, were matched to controls on age (±7 years) and whole blood draw date (±30 days). Conditional logistic regression (using two-sided tests) was used to test for main effects and additive models of effect modification. Results: After a mean follow-up of 16.3 years, coffee consumption was not significantly associated with renal cell cancer risk, when adjusting for blood concentrations of Cd, Hg and Pb and RCC risk factors (age, smoking, BMI, and systolic blood pressure) (p-trend, 0.134). The association with above median blood Pb and RCC (HR = 1.69, 95% CI: 1.06, 2.85) appeared to be modified by coffee consumption, such that RCC risk among individuals with both increased coffee intake and higher blood lead concentration was nearly 3-fold higher RCC risk (HR=3.40, 95% CI: 1.62, 7.13; p-trend 0.003). Conclusion: Contrary to our initial hypothesis, this study suggests that heavy coffee consumption may increase the previously identified association between higher circulating lead (Pb) concentrations and increased RCC risk. Improved assessment of exposure, including potential trace element contaminants in coffee, are needed. Keywords Renal cell cancer • Heavy metals • Coffee consumption • Epidemiology BackgroundWell-established risk factors for renal cell cancer (RCC) include cigarette smoking, elevated blood pressure, and obesity-explaining approximately half of all cases [1]. Other factors which have been associated with RCC include diabetes, low exercise, increased alcohol intake, lead (Pb) exposure, and some occupational exposures [3,40,50].Worldwide, nearly every country has reported increases in the age-adjusted incidence of RCC over the past decade, despite relatively constant population prevalence rates of obesity, smoking and hypertension, and a greater than two-fold increase in the prevalence of controlled hypertension in some countries [50]. Taken together, this suggests the need to identify additional factors for improved RCC prevention. Coffee intake is thought to play a role in chemoprevention of cancer through antioxidant activity of naturally occurring polyphenols in coffee beans (e.g., flavonoids and chlorogenic acids) [33]. Coffee is the major dietary source of polyphenols, accounting for 40 to 45 percent of total daily intake in some populations [10,18]. We and others have identified

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Polyphenols from brown alga, Padina boergesenii (Allendar & Kraft) decelerates renal cancer growth involving cell cycle arrest and induction of apoptosis in renal carcinoma cells

Cited by 14 publications

References 33 publications

Characteristics of Polyphenolic Content in Brown Algae of the Pacific Coast of Russia

Characteristics of Polyphenolic Content in Brown Algae of the Pacific Coast of Russia

Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models

Coffee intake and trace element blood concentrations in association with renal cell cancer among smokers

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