Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases

Niu, Ling; He, Xiuhua; Wang, Qingwen; Fu, Mingyu; Xu, Feng; Xue, Ying; Wang, Zhenzhou; An, Xin-jiang

doi:10.1007/s12013-014-0492-5

Cited by 11 publications

(5 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AA is transformed into prostaglandin (PGE2), which is converted by COXs to eicosanoids (including prostaglandins and leukotrienes), which influence both innate and adaptive immunity [52,53]. The downregulation of COX-2 observed in this study could restrict prostanoid (prostaglandin, thromboxane and prostacyclin) production from AA.…”

Section: Discussionmentioning

confidence: 93%

Human Intervention Study to Assess the Effects of Supplementation with Olive Leaf Extract on Peripheral Blood Mononuclear Cell Gene Expression

Boss

Kao

Murray

et al. 2016

IJMS

View full text Add to dashboard Cite

Olive leaf extract (OLE) has been used for many years for its putative health benefits, but, to date, scientific evidence for the basis of these effects has been weak. Although recent literature has described a link between ailments such as cardiovascular disease, diabetes and cancer and a protective effect of polyphenols in the OLE, the mode of action is still unclear. Here, we describe a double-blinded placebo (PBO)-controlled trial, in which gene expression profiles of peripheral blood mononuclear cells from healthy male volunteers (n = 29) were analysed to identify genes that responded to OLE, following an eight-week intervention with 20 mL daily consumption of either OLE or PBO. Differences between groups were determined using an adjusted linear model. Subsequent analyses indicated downregulation of genes important in inflammatory pathways, lipid metabolism and cancer as a result of OLE consumption. Gene expression was verified by real-time PCR for three genes (EGR1, COX-2 and ID3). The results presented here suggest that OLE consumption may result in health benefits through influencing the expression of genes in inflammatory and metabolic pathways. Future studies with a larger study group, including male and female participants, looking into direct effects of OLE on lipid metabolism and inflammation are warranted.

show abstract

Section: Discussionmentioning

confidence: 93%

Human Intervention Study to Assess the Effects of Supplementation with Olive Leaf Extract on Peripheral Blood Mononuclear Cell Gene Expression

Boss

Kao

Murray

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…Radical scavenger effects may be involved in the reaction with receptors or enzymes that are regulated by antioxidant response elements (e.g. Nrf2) that regulate the redox status in vivo, and some of the anticipated beneficial health effects of polyphenols are today suggested to be mediated through these mechanisms [74].…”

Section: Free Radicals and Antioxidant Activitymentioning

confidence: 99%

Structure–activity relationship of immunomodulating pectins from elderberries

Ahmed

Zou

et al. 2015

Carbohydrate Polymers

View full text Add to dashboard Cite

“…Polyphenols are found in plant-derived foods and beverages. Collective evidence has indicated that natural polyphenols possess multiple protective effects against cardiovascular diseases (Raj et al, 2014 ; Niu et al, 2015 ). Additionally, polyphenols classified to different subclasses have been reported to alleviate cardiac dysfunction and fibrosis following cardiac injury.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Polyphenols in Cardiac Fibrosis

Zhang

Wei

et al. 2018

Front. Pharmacol.

View full text Add to dashboard Cite

Cardiac fibrosis, in response to injury and stress, is central to a broad constellation of cardiovascular diseases. Fibrosis decreases myocardial wall compliance due to extracellular matrix (ECM) accumulation, leading to impaired systolic and diastolic function and causing arrhythmogenesis. Although some conventional drugs, such as β-blockers and renin-angiotensin-aldosterone system (RAAS) inhibitors, have been shown to alleviate cardiac fibrosis in clinical trials, these traditional therapies do not tend to target all the fibrosis-associated mechanisms, and do not hamper the progression of cardiac fibrosis in patients with heart failure. Polyphenols are present in vegetables, fruits, and beverages and had been proposed as attenuators of cardiac fibrosis in different models of cardiovascular diseases. Together with results found in the literature, we can show that some polyphenols exert anti-fibrotic and myocardial protective effects by mediating inflammation, oxidative stress, and fibrotic molecular signals. This review considers an overview of the mechanisms of cardiac fibrosis, illustrates their involvement in different animal models of cardiac fibrosis treated with some polyphenols and projects the future direction and therapeutic potential of polyphenols on cardiac fibrosis.

show abstract

Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases

Cited by 11 publications

References 103 publications

Human Intervention Study to Assess the Effects of Supplementation with Olive Leaf Extract on Peripheral Blood Mononuclear Cell Gene Expression

Human Intervention Study to Assess the Effects of Supplementation with Olive Leaf Extract on Peripheral Blood Mononuclear Cell Gene Expression

Structure–activity relationship of immunomodulating pectins from elderberries

Therapeutic Potential of Polyphenols in Cardiac Fibrosis

Contact Info

Product

Resources

About