Polyphenols of Certain Plants of the Euphorbiaceae Family

Abdulladzhanova, N. G.; Mavlyanov, S. M.; Dalimov, D. N.

doi:10.1023/b:conc.0000003425.70068.85

Cited by 11 publications

(8 citation statements)

References 3 publications

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“…Phytochemical screening: In general, the most active plant extracts from the Euphorbiaceae family displayed the presence of tannins and flavonoids; these facts are in consonance with the polyphenols content of some plants from the Euphorbiaceae family that showed condensate and hydrolysable tannins, flavonoids, among others, responsible for their biological activities (Abdulladzhanova et al 2003). The same way, the alkaloid isolated from the Solanaceae family may be the responsible for the biological activity displayed for these species in this work (Bruneton 2001, Niño et al 2009).…”

Section: Antifungal Activitiessupporting

confidence: 73%

Antibacterial and antifungal activities of crude plant extracts from Colombian biodiversity

Niño

Mosquera

Correa

2012

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Abstract:On a global scale, people have used plants to treat diseases and infections, and this has raised interest on the plant biodiversity potencial in the search of antimicrobial principles. In this work, 75 crude n-hexanes, dichloromethane and methanol extracts from the aerial parts of 25 plants belonging to four botanical families (Asteraceae, Euphorbiaceae, Rubiaceae and Solanaceae), collected at the Natural Regional Park Ucumari (Risaralda, Colombia), were evaluated for their antibacterial and antifungal activities by the agar well diffusion method. The antibacterial activities were assayed against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, and three Gram-negative ones named, Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa. In addition, the same plant extracts were tested against the yeast Candida albicans and the fungi Aspergillus fumigatus and Fusarium solani. Overall, the plant extracts examined displayed better bactericide rather than fungicide activities. In general, the best antibacterial activity was showed by the plant extracts from the Rubiaceae family, followed in order by the extracts from the Euphorbiaceae and Solanaceae ones. It is important to emphasize the great activity displayed by the methanol extract of Alchornea coelophylla (Euphorbiaceae) that inhibited four out of five bacteria tested (B. Subtilis, P. aeruginosa, S. aureus and E. coli). Furthermore, the best Minimal Inhibitory Concentration for the extracts with antifungal activities were displayed by the dichloromethane extracts from Acalypha diversifolia and Euphorbia sp (Euphorbiaceae). The most susceptible fungus evaluated was F. Solani since 60% and 20% of the dichloromethane and methanol extracts evaluated inhibited the growth of this phytopathogenic fungus. The antimicrobial activity of the different plant extracts examined in this work could be related to the secondary metabolites contents and their interaction and susceptibility of pathogenic microorganism evaluated. Rev. Biol. Trop. 60 (4): 1535-1542. Epub 2012 December 01.

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Section: Antifungal Activitiessupporting

confidence: 73%

Antibacterial and antifungal activities of crude plant extracts from Colombian biodiversity

Niño

Mosquera

Correa

2012

RBT

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“…The growth inhibition rates were 93.29 and 90.34% at a concentration of 100 Pg/mL, respectively. Quercetin (7) and myricetin (10) did not show antitumor effects under these conditions [5].…”

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confidence: 89%

“…Phytochemical studies show that Euphorbia helioscopia L. contains mainly terpenoids [2,3], flavonoids [4,5], and polyphenols [6], but few papers report the tannins, alkaloids, and lignans isolated from this plant. Previously, the high contents of quercetin, a plant-derived flavonoid, have been detected in the leaves of Euphorbia helioscopia >7@ and its anticancer properties were demonstrated [8].…”

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confidence: 99%

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Anticancer Constituents of Ethyl Acetate Extract from Euphorbia helioscopia

et al. 2015

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Euphorbia helioscopia L. (Euphorbiaceae), a Chinese medicinal herb, is widely distributed in most parts of China [1]. Phytochemical studies show that Euphorbia helioscopia L. contains mainly terpenoids [2,3], flavonoids [4,5], and polyphenols [6], but few papers report the tannins, alkaloids, and lignans isolated from this plant. Previously, the high contents of quercetin, a plant-derived flavonoid, have been detected in the leaves of Euphorbia helioscopia >7@ and its anticancer properties were demonstrated [8]. Previous experiments [9] studied the antitumor activity of different extracts of Euphorbia helioscopia L. on human hepatocellular carcinoma cell lines SMMC-7721, BEL-7402, and HepG2, gastric carcinoma cell line SGC-7901, and colorectal cancer cell line SW480, and the result have shown that the ethyl acetate extract (EAE) was the main active extract with antitumor effect. In order to evaluate the chemical constituents of the anticancer active fraction, we studied the chemical constituents of the EAE of E. helioscopia. One tannin, two alkaloids, one lignan, four flavonoids, and two phenolic acids compounds were isolated from the EAE of E. helioscopia.Ten known compounds 1-10 were obtained from the EAE by repeated chromatographic methods. The structures were elucidated on the basis of chemical evidence, extensive spectroscopic analysis, and comparison with the literature data. The compounds were identified as follows: 3,3c-di-O-methylellagic acid-4c-O-E-D-glucopyranoside (1) >10@, flazine (2) >11@, N-acetyltryptophan (3) >12@, pinoresinol (4) >13@, protocatechuic acid (5) >5@, gallic acid (6) >14@, quercetin (7) >14@, hyperoside (8) >14@, quercetin-3-O-E-D-glucopyranoside (9) >3@, and myricetin (10) >14@.General Experimental Procedures. NMR spectra were recorded on an INOVA-600 spectrometer ( 1 H: 600 MHz and 13 C: 150 MHz) with TMS as internal standard. UV spectra were obtained on a Shimadzu UV-160 spectrophotometer. HR-ESI-MS were recorded on an APEX II FT-ICR mass spectrometer. Column chromatography was carried out with Sephadex LH-20 (Pharmacia Biotech Company, Sweden), and silica gel (100-200 and 200-300 mesh, Qingdao Extraction and Isolation. The dried whole plant of E. helioscopia L. (3 kg) was extracted three times (2, 2, 1 h) with water (14 times volume) and then filtered. The filtrate was concentrated to a small volume at room temperature. The residue was precipitated with 70% ethanol and allowed to stand for about 24 h at room temperature and then filtrated. The filtrate was evaporated under reduced pressure using a rotary evaporator (BUCHI, Switzerland) to give the crude extract (300 g). The crude extract was dissolved in water and fractionated using petroleum ether, chloroform, ethyl acetate, and n-butanol, successively. Portions of the extracts of each fractionation step were evaporated to dryness under vacuum. The EAE (36.7 g) was chromatographed on a silica gel column eluting with a methylene chloride-methanol gradient (36:1-1:1) to give eleven fractions (E1-E11). Fractions E5 and E6 were suc...

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“…The Euphorbiaceae family presents a large variety of secondary metabolites, and the major types include alkaloids [23], triterpenoids [48,49], flavonoids (both Cand O-glycosides) [49,50], diterpenoids [23], tannins, and peptides (cyclic and linear) [13,24,48]. According to the literature, all orbitides isolated from Euphorbiaceae to date consist exclusively of L-amino acids.…”

Section: Euphorbiaceae Familymentioning

confidence: 99%

Biologically Active Orbitides from the Euphorbiaceae Family

et al. 2017

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A comprehensive overview of natural orbitides isolated from Euphorbiaceae species and their most relevant biological activities are presented. Euphorbiaceae is a large and diverse family, which comprises about 300 genera, and is known as an important source of medicines and toxins. Several classes of secondary metabolites have been described for this taxon, however, orbitides have been broadly reported in and genera. Additionally, the latex is documented as the main source of orbitides in this family. Based on their structural and functional diversity, orbitides present a large variety of biological activities described as cytotoxicity, antimalarial, antibacterial, antifungal, enzymatic inhibition, and immunosuppressive, although the mechanism of action still needs to be further investigated. In recent years, the discovery of bioactive cyclic peptides from different sources has grown exponentially, making them promising molecules in the search for new drug leads. This review also highlights the attempts made by many researchers to organize the orbitides nomenclature and amino acid numbering, as well the important progress recently achieved in the biosynthetic study area.

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Polyphenols of Certain Plants of the Euphorbiaceae Family

Cited by 11 publications

References 3 publications

Antibacterial and antifungal activities of crude plant extracts from Colombian biodiversity

Antibacterial and antifungal activities of crude plant extracts from Colombian biodiversity

Anticancer Constituents of Ethyl Acetate Extract from Euphorbia helioscopia

Biologically Active Orbitides from the Euphorbiaceae Family

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