Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

Wang, Enhua; Yang, Lishou; Yang, Qian; Yang, Fang; Luo, Jing‐Li; Gan, Menglan; Wang, Xue; Song, Shanmin; Yang, Liu; Xiao-sheng, Yang

doi:10.1039/d2ra03562f

RSC Adv.

2022

DOI: 10.1039/d2ra03562f

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Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

Enhua Wang¹,

Lishou Yang

Qian Yang³

et al.

Abstract: We report herein an efficient polyphosphoric acid (PPA) promoted one-pot protocol for the synthesis of flavanone derivatives from 2-hydroxyacetophenones and benzaldehydes.

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Cited by 4 publications

References 49 publications

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Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity

Troshkova,

Politanskaya,

Bagryanskaya

et al. 2023

Mol Divers

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Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity

Troshkova,

Politanskaya,

Bagryanskaya

et al. 2023

Mol Divers

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Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Mousavi,

Rimaz,

Zeynizadeh

2024

ACS Chem. Neurosci.

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Neurodegenerative diseases (NDs) are one of the prominent health challenges facing contemporary society, and many efforts have been made to overcome and (or) control it. In this research paper, we described a practical one-pot two-step three-component reaction between 3,4-dihydronaphthalen-1(2H)one (1), aryl(or heteroaryl)glyoxal monohydrates (2a−h), and hydrazine monohydrate (NH 2 NH 2 •H 2 O) for the regioselective preparation of some 3-aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnoline derivatives (3a−h). After synthesis and characterization of the mentioned cinnolines (3a−h), the in silico multi-targeting inhibitory properties of these heterocyclic scaffolds have been investigated upon various Homo sapiens-type enzymes, including

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Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones

Liu

Wang³

et al. 2023

Molecules

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Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of N-alkyl-4-quinolones is described. This novel strategy features the first proof of polyphosphate ester (PPE) as a dual hydrogen-bonding catalyst and the use of readily available starting materials for the preparation of N-alkyl-4-quinolones. The method provides a diversity of N-alkyl-4-quinolones in moderate to good yields. The compound 4h demonstrated good neuroprotective activity against N-methyl-ᴅ-aspartate (NMDA)-induced excitotoxicity in PC12 cells.

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Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells

Abstract: We report herein an efficient polyphosphoric acid (PPA) promoted one-pot protocol for the synthesis of flavanone derivatives from 2-hydroxyacetophenones and benzaldehydes.

Cited by 4 publications

References 49 publications

Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity

Fluorinated 2-arylchroman-4-ones and their derivatives: synthesis, structure and antiviral activity

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Hydrogen Bond Assisted Three-Component Tandem Reactions to Access N-Alkyl-4-Quinolones

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