Polyphyllin I attenuates cognitive impairments and reduces AD‐like pathology through CIP2A‐PP2A signaling pathway in 3XTg‐AD mice

Abstract

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Polyphyllin I alleviates neuroinflammation after cerebral ischemia–reperfusion injury via facilitating autophagy-mediated M2 microglial polarization

“…PPI shows anti-cancer property in osteosarcoma by inhibiting growth and inducing apoptosis through inactivating Wnt/β-catenin pathway in vitro and in vivo (Chang et al 2017 ). In 3XTg Alzheimer’s disease mice model, PPI reduces cognitive impairments and Alzheimer’s disease like pathology via suppressing CIP2A expression and PP2A re-activation (Zhou et al 2020 ). In rheumatoid arthritis, PPI ameliorates synovial inflammation in the ankle joint by suppressing M1 macrophage polarization and T cell infiltration through NF-κB inhibition (Wang et al 2018 ).…”

Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss

“…The PVDF membranes were then incubated overnight at 4 °C in TBST rabbit anti-GluN2A (1:1000, Cell Signaling Technology, #4205, RRID: AB_2112295) and rabbit anti-GluN2B (1:1000, Cell Signaling Technology, #4207, RRID: AB_1264223) antibodies, which have been described in previous studies (Taniguchi et al 2009 ; Unsicker et al 2021 ). To examine GluA1, GluA2, syntaxin 1A, and PSD95 expression, Western blot analysis was performed as described in a previous study (Zhou et al 2020 ; Borland et al 2020 ; Zhang et al 2021 ; Huang et al 2021 ). Western blots were performed with rabbit anti-GluA1 (1:1000, Cell Signaling Technology, #13185, RRID: AB_2732897), rabbit anti-GluA2 (1:1000, Cell Signaling Technology, #5306, RRID: AB_10622024), rabbit anti-syntaxin 1A (1:1000, Cell Signaling Technology, #18572, RRID: AB_2798803), and rabbit anti-PSD95 (1:1000, Abcam, ab18258, RRID: AB_444362) antibodies.…”

C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies

“…In the last decade, various approaches have been undertaken to reach these goals [17]. The including I2/SET [42], CIP2A [43] and PME-1 [44] (Fig. 1).…”

“…1). In addition, complex natural products have also been suggested to activate PP2A, such as polyphyllin I [43] (Fig. 1), cornel iridoid glycosides [48], Gingko Biloba extract [49] or pseudoginsenoside-F11 [50].…”