Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition

Capote, R.; Alonso-Lebrero, José Luis; García, Fernando; Brieva, Aurora; Pivel, J.P.; González, Salvador

doi:10.1016/j.jphotobiol.2005.11.005

Cited by 62 publications

(47 citation statements)

References 25 publications

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“…11,12 Although the mechanism has not been completely elucidated, it involves inhibition of UV-induced reactive oxygen species production and prevention of other UVinduced damages such as trans-urocanic acid isomerization, DNA damage leading to p53-mediated apoptosis, or degradative matrix remodeling. [13][14][15] Several lines of evidence indicate that reactive oxygen species are involved in the pathogenesis of PLE. 6,16 Given its well-known antioxidant activities we hypothesized that oral intake of PL may prevent or delay the induction of PLE lesions by repetitive exposure to artificial UVB or UVA light.…”

Section: Discussionmentioning

confidence: 99%

Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption

Tanew¹,

Radaković²,

González³

et al. 2012

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption

Tanew¹,

Radaković²,

González³

et al. 2012

Journal of the American Academy of Dermatology

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“…PL prevents the elimination of Langerhans cells induced by UV irradiation during direct UV exposure [35], or PUVA-therapy [28]. It also inhibits the isomerization of trans -urocanic acid into the cis form and prevents further photo-induced breakdown and degradation in a cell-free system [34]. Finally, analysis of the blood and skin of mice treated orally with PL and subsequently irradiated with UV revealed that PL decreased the levels of oxidized glutathione and increased the activity of the enzyme catalase, suggesting a positive systemic effect in the antioxidant systems, particularly in skin [35].…”

Section: Fernblock: a Multi-pronged Approach To Photoprotectionmentioning

confidence: 99%

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

González

Gilaberte

Philips

et al. 2011

IJMS

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Many phytochemicals are endowed with photoprotective properties, i.e., the capability to prevent the harmful effects of excessive exposure to ultraviolet (UV) light. These effects include photoaging and skin cancer, and immunosuppression. Photoprotection is endowed through two major modes of action: UV absorption or reflection/scattering; and tissue repair post-exposure. We and others have uncovered the photoprotective properties of an extract of the fern Polypodium leucotomos (commercial name Fernblock). Fernblock is an all-natural antioxidant extract, administered both topically (on the skin) or orally. It inhibits generation of reactive oxygen species (ROS) production induced by UV including superoxide anion. It also prevents damage to the DNA, inhibits UV-induced AP1 and NF-κB, and protects endogenous skin natural antioxidant systems, i.e., CAT, GSH, and GSSR. Its photoprotective effects at a cellular level include a marked decrease of UV-mediated cellular apoptosis and necrosis and a profound inhibition of extracellular matrix remodeling. These molecular and cellular effects translate into long-term inhibition of photoaging and carcinogenesis that, together with its lack of toxicity, postulate its use as a novel-generation photoprotective nutriceutical of phytochemical origin.

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“…It induces direct and indirect adverse biological effects, including the formation of pyrimidine photoproducts (Katiyar 2005), isomerization of trans-to cis-urocanic acid (Capote et al, 2006), induction of ornithine decarboxylase activity (Ahmad and Gilliam, 2001), stimulation of DNA synthesis (Andley et al, 1996), free radical production (Aitken et al, 2007), photoaging (Park et al, 2010) and photocarcinogenesis (Gruijl, 2000). It is considered to be responsible for inducing skin cancer (squamous and basal cell carcinoma) and immunosuppression (Adhami et al, 2008;.…”

Section: * Corresponding Authormentioning

confidence: 99%

Photoprotection of natural flavonoids

Saewan

Jimtaisong²

2013

J App Pharm Sci

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Overexposure to ultraviolet (UV) radiation can cause a number of skin disorders such as erythema, edema, hyperpigmentation, immunosuppression, photoaging, and skin cancer. Since the level of UV radiation is increasing as a result of depletion of the stratospheric ozone and climate change, the protection of human skin against the harmful effects of UV radiation is an urgent need. Topical application of sunscreens is a strategy to protect the deleterious effect of UV radiation on the skin. Sunscreens today contain one or several synthetic UV filter molecules which protect the UV radiation exposed on the epidermis. These molecules are broadly divided into physical and chemical agents. Physical sunscreens reflect and scatter UVB, UVA and visible radiation. Chemical sunscreens act by absorbing ultraviolet radiation and re-emitting chemical energy as heat or light. Several synthetic UV filter molecules are available in the market but they have limited use because these active molecules may create adverse effects on human skin. Some information on possible photon induced reaction such as photoirritation, photosensitization and contact dermatitis by sunscreen products containing synthetic organic sunscreen agents. To overcome these side effects, naturally occurring compounds have gained considerable attention as photoprotective agents. Flavonoids, a group of natural occurring compounds, act as catalysts in the light phase of photosynthesis and as stress protectants in plant cells by scavenging reactive oxygen species (ROS). Natural flavonoids have the potential photoprotection because of their UV absorbing, their ability to act as direct and indirect antioxidants as well as anti-inflammatory and immunomodulatory agents which provide exciting platforms for the development of photoprotection. This review summarizes the structure and potential photoprotection activity of several natural flavonoids.

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Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition

Cited by 62 publications

References 25 publications

Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption

Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

Photoprotection of natural flavonoids

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