Polypoid and junctional squamous cell carcinoma of the tongue and larynx with spindle cell carcinoma (“PSEUDOSARCOMA”)

Sherwin, Russell P.; Strong, M. Stuart; Vaughn, Charles W.

doi:10.1002/1097-0142(196301)16:1<51::aid-cncr2820160108>3.0.co;2-2

Cited by 103 publications

(24 citation statements)

References 9 publications

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“…Disease progression in sarcomatoid carcinoma is reported to be characterized by recurrences and metastases [2,3,9,[14][15][16][17]. This was seen in 13 of the 39 patients (33.3%) where follow-up data could be obtained.…”

Section: Clinical Outcome and Follow-upmentioning

confidence: 99%

“…A large number of patients presented with advanced disease stage, again a common occurrence in this part of the world [33,34]. The clinical and gross appearance of a polypoid configuration have been widely reported and characterize these tumors [2,3,[10][11][12][13][14][15][16][17][23][24][25].…”

Section: Clinical Parametersmentioning

confidence: 99%

“…Sarcomatoid (spindle cell) carcinomas of the head and neck are unusual variants of squamous carcinoma commonly reported in the larynx but also described in other mucosal sites such as gingiva, tongue, hypopharynx and nasal cavity [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. These tumors have now been proved to be monoclonal, evolving from conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Viswanathan

Rahman

Pallavi

et al. 2010

Head and Neck Pathol

170

177

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Sarcomatoid carcinomas are biphasic tumors proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. This study evaluates their clinicopathologic characteristics in head and neck mucosal sites and the problems in distinguishing them from other spindle cell tumors. A total of 103 cases with a confirmed diagnosis of sarcomatoid carcinoma accessioned in the pathology department of a tertiary referral cancer centre over a period of 7 years (2004)(2005)(2006)(2007)(2008)(2009)(2010) were studied. An algorithm used for their diagnosis is presented. Ages of the patients were 22-90 years (median 53 years), and male:female ratio was 3.7:1. Site distribution was oral cavity (n = 65, 63.1%), larynx (18, 17.5%), oropharynx/hypopharynx (12, 10.7%), maxilla (6, 5.8%) and metastatic nodes (2, 1.9%). A large number of patients (95%) presented with a mass lesion of less than 1 year duration. Histopathologically, epithelial differentiation was evident on morphology in 48 (46.6%) cases, only on IHC in 34 (33%) cases, and in 21 (20.4%) no epithelial differentiation was seen. Typically, tumors were polypoidal (92, 89.3%) and ulcerated (95, 92.2%) with cells arranged predominantly in fascicles (59, 57.3%) or storiform pattern (17, 16.5%) amidst collagenous (50, 48.5%) or myxoid matrix (35, 34%). Anaplasia (2?/3?) and mitosis[10 per 10 HPF were noted in 96 (93.2%) cases. IHC was done in 82 cases; 55 (66.7%) showed positivity for epithelial markers with aberrant expression of mesenchymal markers in 43 (41.7%). Diagnosis of sarcomatoid squamous carcinoma is challenging because of overlapping histopathological features with other spindle cell tumors. Understanding their clinicopathologic characteristics facilitates their diagnosis and appropriate clinical management.

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Section: Clinical Outcome and Follow-upmentioning

confidence: 99%

Section: Clinical Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Viswanathan

Rahman

Pallavi

et al. 2010

Head and Neck Pathol

170

177

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“…Both lesions have elements of carcinoma and sarcoma but can be differentiated by the relationship between the two components. In the carcinosarcoma, the sarcomatous and carcinomatous elements intermingle, whereas in the pseudosarcoma these cell types appear separately, although adjacent to each other (Pearlman, 1940;Elton and Joannides, 1962;Moore et al, 1963;Sherwin et al, 1963;Talbert et al, 1963;DeMarco et al, 1965;Razzuk et al, 1971). The nature of the sarcomatous elements in the pseudosarcoma has been debated.…”

Section: Discussionmentioning

confidence: 99%

Pseudosarcoma of the oesophagus

Shields

Eilert

Battifora

1972

Thorax

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“…The relationship has seemed, in most cases, to be that a carcinoma has provoked a sarcoma-like reaction in its vicinity and has thus been kept superficial by the exuberant reaction. Tumours of this type are well recognized in the oral, faucial, and laryngeal regions (Lane, 1957;Baker, 1959;Sherwin, Strong, and Vaughn, 1963;Appleman and Oberman, 1965)~ and it was the benign behaviour of the sarcomatous element in these tumours that led Lane to suggest the name ' pseudosarcoma'. The recognition of apparently similar tumours in the oesophagus led Stout and Lattes (1957) to suggest that such tumours in the oesophagus would behave like the morphologically similar tumours of the oral, faucial, and laryngeal regions.…”

Section: Discussionmentioning

confidence: 99%

Pseudosarcoma of the oesophagus

Hughes¹,

Cruickshank

1969

Journal of British Surgery

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this appointment, but was admitted to my ward with severe haematemesis the following year. In view of these series of haematemeses and negative radiographs, a laparotomy was carried out. At operation the gastro-enterostomy was rotated upon itself causing engorgement of the vessels. The constriction at the duodenojejunal junction was rectified by removing a thick fibrous band and enlarging the lumen. It was then realized that the gastro-enterostomy could now serve no useful purpose. It was, therefore, undone and the parts restored to normal. Careful examination failed to show any evidence of a gastric ulcer. The haematemeses were probably due to engorgement of the vessels leading to superficial erosions. Subsequent fibrescopic examination showed no pathology and he has remained fit and well ever since. There were 7 cases for which a duodenojejunostomy was performed (Table ZZ). T h e y quite fortuitously did somewhat better. Only I required a subsequent operation and this was for a n osteitis of one of his metatarsal bones at the age of 3 years.Case 8.-The youngest in the series is E. M., who also had a duodenojejunostomy and proved of special interest. She was admitted in a moribund state at the age of 5 days. She was collapsed, cyanosed, with a high-pitched cry, and was at first thought to be suffering from some cerebral condition. A radiograph, carried out later more by chance than clinical acumen, showed a duodenal atresia. Following resuscitation, a laparotomy revealed this obstruction at the junction of the second and third parts of the duodenum so a duodenojejunostomy was performed. As the abdominal wound was being sutured, she had cardiac arrest. A thoracotomy and cardiac massage were performed and it was 3 minutes before spontaneous cardiac contractions returned. Following this she made a rapid and complete recovery. Her E.C.G. is normal, chest radiograph is normal, and the barium meal shows a normally functioning duodenojejunostomy (Fig. 8).Probably the most gratifying feature is that the survivors from this congenital abnormality are all perfectly normal individuals and the type of operation done does not seem to make much difference (Fig. 9).A NUMBER of cases, totalling just over 30, of turnours termed 'pseudosarcomas of the oesophagus' have been reported in the literature and the majority have been treated by excision of the oesophagus; the subsequent history of our personal case confirms the advisability of this major procedure. CASE REPORTA male patient, aged 57, gave a history of having had pain for a month in the epigastrium, occurring immediately after eating solid food; taking fluids did not cause any pain. He had one episode of vomiting 'coffee-ground' material I week before his admission.On examination, the only positive clinical finding was evidence of a mild degree of loss of weight. A bariumswallow radiograph (Fig. I) revealed a large intraluminary filling defect with a nodular outline in the lower third of the oesophagus, causing no gross obstruction but occupying a length of 4-5 in. Oesoph...

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Polypoid and junctional squamous cell carcinoma of the tongue and larynx with spindle cell carcinoma (“PSEUDOSARCOMA”)

Cited by 103 publications

References 9 publications

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Pseudosarcoma of the oesophagus

Pseudosarcoma of the oesophagus

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