Polyprenols from the needles of Taxus chinensis var. mairei

Yu, Jianchun; Wang, Yanbin; Hua, Qian; Zhao, Yunpeng; Liu, Bentong; Fu, Chengxin

doi:10.1016/j.fitote.2012.01.007

Cited by 23 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The injection volume was 0.5 µL. The mobile phase was directly on-line degassed, and its composition consisted of isopropanol (CH 3 ) 2 CHOH (Merck, Branchburg, NJ, USA, HPLC grade) (Solvent A) and methanol CH 3 OH (Fisher Scientific UK, Loughborough, United kingdom, HPLC grade) (Solvent B) at a flow rate of 0.22 mL/min with following elution program: initial -35% A, 65% B for 1.5 min; 75% A, 25% B 1.5-10 min, constant amount of 75% A, 25% B was kept for 15 min, 45% A, 55% B 25-30 min, finally 35% A, 65% B 30-32 min [53].…”

Section: Reverse-phase Uhplc Analysismentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

View full text Add to dashboard Cite

The needles of conifer trees are one of the richest sources of natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) were observed in the ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram of Siberian fir with the most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% of the total polyprenol yield). Abies sibirica L. polyprenol solubility and incorporation efficiency into liposomes were studied in various commercially available lecithin mixtures (Phosal IP40, Phosal 75SA, and Lipoid P45). The resulting multilamellar polyprenol liposomes were morphologically characterized by Light and Transmission Electron Microscopy, and the liposome size was discovered to be polymodal with the main peak at 1360 nm (90% of the volume). As polyprenols are fully soluble only in lipids, a liposomal formulation based upon co-solubilization and a modified ethanol injection method of polyprenols into the ethanol-phospholipid system was developed for the entrapment and delivery of polyprenols for potential commercial applications in food supplement and cosmetic industries.

show abstract

Section: Reverse-phase Uhplc Analysismentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The purity of the total TPs was assessed using HPLC ( Fig. 2), amounting to485% (Yu et al, 2012). Polyene phosphatidylcholine (PP, A. Nattermann & Cie. GmbH), a compound with a similar chemical structure to polyprenols that has been used widely to treat acute and chronic liver disorders (Okiyama et al, 2009), was used as a reference.…”

Section: Drugsmentioning

confidence: 99%

Polyprenols from Taxus chinensis var. mairei prevent the development of CCl4-induced liver fibrosis in rats

Wang

Hua

et al. 2012

Journal of Ethnopharmacology

Self Cite

View full text Add to dashboard Cite

“…1). The first type is polyprenol (structure 1), allylic alcohols with a single double bond in each isoprenoid unit (α-unsaturated isoprenoid alcohols), which are characteristics of bacterial cells (Wolucka et al, 1994), plant photosynthetic tissues (Swiezewska & Chojnacki, 1991;Kurisaki et al, 1997;Tateyama et al, 1999;Skorupinska-Tudek et al, 2003), shoots (Kurisaki et al, 1997), seeds (Kurisaki et al, 1997;Tateyama et al, 1999;Skorupinska-Tudek et al, 2003), needles (Yu et al, 2012), flowers (Tateyama et al, 1999), and cultured cells (Skorupinska-Tudek et al, 2007). The second type is dolichol (structure 2) without a double bond in the OH-terminal isoprenoid unit (α-saturated isoprenoid alcohols).…”

Section: Introductionmentioning

confidence: 99%

Diversity of polyisoprenoids in ten Okinawan mangroves

et al. 2016

View full text Add to dashboard Cite

The distribution and occurrence of polyisoprenoids (dolichols and polyprenols) in the leaves and roots of nine true Okinawan mangroves and the leaves of one associate mangrove were analyzed using two-dimensional thin layer chromatography. In the leaves, the distribution of three types (I, II, and III) of polyprenols and dolichols were detected. (I) The predominance of dolichols over polyprenols (more than 90%) was observed in Avicennia marina, Bruguiera gymnorrhiza, B. gymnorrhiza (yellow leaves), and Rhizophora stylosa. (II) The occurrence of both polyprenols and dolichols is observed in Excoecaria agallocha, Kandelia obovata, K. obovata (yellow leaves), Lumnitzera racemosa, Pemphis acidula, and Sonneratia alba. (III) The predominance of polyprenols over dolichols (more than 90%) is observed in Heritiera littoralis and Hibiscus tiliaceus. However, in the roots, a type-I distribution was observed in A. marina, B. gymnorrhiza, E. agallocha, H. littoralis and S. alba. A type-II distribution was observed in K. obovata, L. racemosa, P. acidula, and R. stylosa with no type-III distribution. The chain-length distribution of dolichols in the leaves and roots was C 50-C 140 and C 60-C 120 , respectively. A similar chain-length distribution of polyprenols of C 45-C 140 and C 65-C 85 was detected in the leaves and roots respectively. Taken together, sixteen out of twenty-one tissues indicated that dolichols are more abundant than polyprenols in both leaves and roots. The present study is the first to clarify the diversity of polyisoprenoids in both the leaves and roots of mangrove, suggesting the chemotaxonomic significance of polyisoprenoids in the mangrove tree species.

show abstract

Polyprenols from the needles of Taxus chinensis var. mairei

Cited by 23 publications

References 26 publications

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Polyprenols from Taxus chinensis var. mairei prevent the development of CCl4-induced liver fibrosis in rats

Diversity of polyisoprenoids in ten Okinawan mangroves

Contact Info

Product

Resources

About