Polyprenols of<i>Ginkgo biloba</i>Enhance Antibacterial Activity of Five Classes of Antibiotics

Tao, Ran; Wang, Chengzhang; Ye, Jianzhong; Zhou, Hao; Chen, Hongxia

doi:10.1155/2016/4191938

Cited by 20 publications

(10 citation statements)

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“…Polyprenols extracted from different plants and also animal sources vary in chain lengths of their homologs and geometrical configuration [7]. Popular plant sources for polyprenol extraction on a commercial scale are conifer biomass such as Abies sibirica L., Picea abies L., Pinus sibirica L., Pinus sylvestris L. [8] and Ginkgo biloba L. [9,10]. Previously, the chemical composition of Pinaceae polyprenols has been described in their phosphorylated [11][12][13] and acetate forms [14].…”

Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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The needles of conifer trees are one of the richest sources of natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) were observed in the ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram of Siberian fir with the most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% of the total polyprenol yield). Abies sibirica L. polyprenol solubility and incorporation efficiency into liposomes were studied in various commercially available lecithin mixtures (Phosal IP40, Phosal 75SA, and Lipoid P45). The resulting multilamellar polyprenol liposomes were morphologically characterized by Light and Transmission Electron Microscopy, and the liposome size was discovered to be polymodal with the main peak at 1360 nm (90% of the volume). As polyprenols are fully soluble only in lipids, a liposomal formulation based upon co-solubilization and a modified ethanol injection method of polyprenols into the ethanol-phospholipid system was developed for the entrapment and delivery of polyprenols for potential commercial applications in food supplement and cosmetic industries.

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Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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“…Mangroves plants are known to produce a varied range of secondary metabolites such as sterols, ubiquinones, isoprenoids, and polyisoprenoids. Polyisoprenoid comprised polyprenol and dolichol, which is efficacious to have anticancer and antibacterial activities [1], [2], [3]. The composition and diversity of polyisoprenoids compounds in North Sumatran mangrove forests, Indonesia, have been described [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Apoptotic with Double-Staining Test, P53, and Cyclooxygenase-2 to Proliferation Colon Cancer Cell (WiDr) of Dolichol in Three Mangrove Leaves

Istiqomah¹,

Basyuni²,

Hasibuan³

2020

Open Access Maced J Med Sci

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BACKGROUND: Mangroves secondary metabolites are mostly consisting of sterols, ubiquinones, isoprenoids, and polyisoprenoids. Polyisoprenoid is divided into two types, namely, polyprenol and dolichol, which has been reported to have biological and pharmacological activities. AIM: This research was aimed to analyze apoptosis 48 h with double staining and immunocytochemistry (ICC) 48 h of P53 and cyclooxygenase-2 (COX-2) gene expression from chemical constituents of dolichol in three mangrove leaves of Ceriops tagal, Nypa fruticans, and Rhizophora mucronata. METHODS: Apoptosis with the double-staining method was employed to analyze the genes expression in growth and development of cancer cells, P53, and COX-2 with ICC and flow cytometry method. The data were statistically analyzed using one-way ANOVA parametric statistical analysis followed by Duncan’s test. RESULTS: The result revealed that the increased apoptosis of samples C. tagal was 70% fluorescence orange, while N. fruticans and R. mucronata were 35% and 30% fluorescence orange, respectively. However, it was compared with the positive control; it produced orange fluorescent as much as 75%, suggesting that C. tagal have a position similar to 5-FU. Predominance dolichol in N. fruticans and C. tagal leaves led the expression gene of p53 to have 1.57% M1 phase, indicating the domination in G0-G1 phase (70–80%). Inhibit the expression for 48 h in p53 and COX-2 showing that n-hexane extract of C. tagal had the most percentage (80.733 ± 0.11%) to upregulate the p53 and less percentage (20.16 ± 1.19%) to downregulate the COX-2, indicating positive extract belong to N. fruticans and R. mucronata leaves. CONCLUSION: The present study confirmed the pharmacological properties of dolichol from three mangrove leaves as an anticancer of tumor suppressor genes and significantly proliferated of cancer cell growth from mangrove leaves.

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“…GBPs were shown to possess antimicrobial activity against Salmonella enterica , Staphylocococus aureus , Aspergillus niger , Escherichia coli , and Bacillus subtilis (Tao et al, 2013). Moreover, GBPs have demonstrated a capacity to enhance the antibacterial activity of antibiotics (Tao et al, 2016). Due to their highly apolar chemical character, it’s unlikely that these compounds could be responsible for the activity of our extracts.…”

Section: Discussionmentioning

confidence: 99%

Validation of a 16th Century Traditional Chinese Medicine Use of Ginkgo biloba as a Topical Antimicrobial

et al. 2019

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In the search for new therapeutic solutions to address an increasing number of multidrug-resistant bacterial pathogens, secondary metabolites from plants have proven to be a rich source of antimicrobial compounds. Ginkgo biloba , a tree native to China, has been spread around the world as an ornamental tree. Its seeds have been used as snacks and medical materials in Traditional Chinese Medicine (TCM), while over the last century its leaf extracts emerged as a source of rising pharmaceutical commerce related to brain health in Western medicine. Besides studies on the neuro-protective effects of Ginkgo, its antibacterial activities have gained more attention from researchers in the past decades, though its leaves were the main focus. We reviewed a 16th-century Chinese text, the Ben Cao Gang Mu by Li Shi-Zhen, to investigate the ancient prescription of Ginkgo seeds for skin infections. We performed antibacterial assays on various Ginkgo seed extracts against pathogens ( Staphylococcus aureus , Cutibacterium acnes , Klebsiella pneumoniae , Acinetobacter baumannii, Streptococcus pyogenes ) relevant to skin and soft tissue infections (SSTIs). We demonstrate here that Ginkgo seed coats and immature seeds exhibit antibacterial activity against Gram-positive skin pathogens ( C. acnes, S. aureus , and S. pyogenes ), and thus validated its use in TCM. We also identified one compound tied to the antibacterial activity observed, ginkgolic acid C15:1, and examine its toxicity to human keratinocytes. These results highlight the relevance of ancient medical texts as leads for the discovery of natural products with antimicrobial activities.

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Polyprenols ofGinkgo bilobaEnhance Antibacterial Activity of Five Classes of Antibiotics

Cited by 20 publications

References 23 publications

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Apoptotic with Double-Staining Test, P53, and Cyclooxygenase-2 to Proliferation Colon Cancer Cell (WiDr) of Dolichol in Three Mangrove Leaves

Validation of a 16th Century Traditional Chinese Medicine Use of Ginkgo biloba as a Topical Antimicrobial

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