Polypyrrole/Alginate Hybrid Hydrogels: Electrically Conductive and Soft Biomaterials for Human Mesenchymal Stem Cell Culture and Potential Neural Tissue Engineering Applications

Yang, Sumi; Jang, Lindy K.; Kim, Semin; Yang, Jongcheol; Yang, Kisuk; Cho, Seung Woo; Lee, Jae Young

doi:10.1002/mabi.201600148

Cited by 151 publications

(120 citation statements)

References 58 publications

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“…Although rat PC12 cells are a good model for neuronal growth behavior, it is vital to expand the scope of conductive scaffolds to human cell lines. To fulfill this need, Yang et al used an alignate hydrogel integrated with PPy to culture human MSCs (hMSCs). Adding PPy content (2–10%) to the pristine scaffold led to proportionally stiffer, from 25 to 200 kPa, and more conductive, 8 × 10 −6 to 1 × 10 −4 S cm −1 , hydrogels.…”

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

118

102

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

118

102

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“…Proper concentrations of extracellular ions help the hydrogel to maintain its morphology and adhere the cells to the hydrogel, instead of forming cell aggregates. A similar strategy has been used in other studies (Runge et al, 2010;Yang et al, 2016), in which the charge of hydrogel component, whether they are on polymers or small ions, help to maintain the hydrogel's structure and morphology, and affect the cell behavior.…”

Section: Ehs Used As Cells Culture Matrixmentioning

confidence: 99%

Electroconductive hydrogels for biomedical applications

Han

Zhang

2019

WIREs Nanomed Nanobiotechnol

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Electroconductive hydrogels (EHs), combining both the biomimetic features of hydrogels and the electrochemical properties of conductive polymers and carbon‐based materials, have received immense considerations over the past decade. The three‐dimensional porous structure, hydrophilic properties, and regulatable chemical and physical properties of EH resemble the extracellular matrix in tissues, enable EHs a good matrix for cell growth, proliferation, and migration. Different from nonconductive hydrogels, EHs possess high electrical conductivity and electrochemical redox properties, which can be utilized to detect electric signals generated in biological systems, and also to supply electrical stimulation to regulate the activity and function of cells and tissues. Hence, this article provides a summary of the new development of EH for biomedical applications in the decade. We give a brief introduction of the design and synthesis of EHs, as well as current applications of EHs in biomedical fields, including cell culture, tissue engineering, drug delivery and controlled release, biosensors, and implantable bioelectronics. The development trends and challenges of EHs for biomedical applications are also discussed. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…Among the various substrate materials that have been evaluated, conducting polymers have received considerable attention as transducers in electrochemical sensors . Polypyrrole (PPy), for example, is easily synthesized and boasts several advantages including high electric conductivity, high chemical and electrical stability, and high polarity . In particular, 1D PPy structures have demonstrated outstanding biosensing performance .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Shape‐Controlled Palladium Nanoparticle‐Decorated Electrospun Polypyrrole/Polyacrylonitrile Nanofibers for Hydrogen Peroxide Coalescing Detection

Kim

Shin

Jun

et al. 2017

Adv Materials Inter

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Shape‐controlled palladium nanoparticle‐decorated electrospun polypyrrole/polyacrylonitrile nanofibers (Pd_PPy/PAN NFs) are fabricated by electrospinning, vapor deposition polymerization (VDP), and electrodeposition. The electrospun PAN NFs are used as the framework for a composite nanomaterial. To make the material electrically conductive, the framework is coated with PPy by VDP. As‐prepared PPy/PAN NFs are used as the working electrode during electrodeposition of Pd. During Pd introduction, the presence of sulfuric acid in the electrolyte influences the shape of the Pd nanoparticles. Sulfate ions prevent the growth of the Pd, resulting in nanoparticles with sharp features. The fabricated Pd_PPy/PAN NFs are then incorporated as the active element in an electrochemical hydrogen peroxide (H2O2) biosensor. Tailoring the morphology of the Pd nanoparticles enables a minimum detectable limit of 1 × 10−9m H2O2, which is sufficiently low for monitoring diseases related to H2O2 concentration, such as Parkinson's disease and Alzheimer's disease. The low detection limit is achieved by coalescing detection of Pd and PPy.

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Polypyrrole/Alginate Hybrid Hydrogels: Electrically Conductive and Soft Biomaterials for Human Mesenchymal Stem Cell Culture and Potential Neural Tissue Engineering Applications

Cited by 151 publications

References 58 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Electroconductive hydrogels for biomedical applications

Fabrication of Shape‐Controlled Palladium Nanoparticle‐Decorated Electrospun Polypyrrole/Polyacrylonitrile Nanofibers for Hydrogen Peroxide Coalescing Detection

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