Polyrotaxanes

Harada, Akira; Hashidzume, Akihito; Yamaguchi, Hiroyasu; Takashima, Yoshinori

doi:10.1002/0471440264.pst573

Cited by 25 publications

(31 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, supramolecular polymers have attracted much research interest . A classic example of these supramolecular structures is polyrotaxanes (PRs), which are formed by the nonbonded interactions of hollow macrocycles threaded onto a single linear polymer chain . Cyclodextrins (CDs) are a more‐common macrocycle .…”

Section: Introductionmentioning

confidence: 99%

New Insights on the Self‐Organization of PEG/α‐Cyclodextrin‐Based Polyrotaxanes in Solution: An Experimental and Theoretical Study

Peña-Bahamonde

Atencia

Pozuelo

et al. 2013

Macro Chemistry & Physics

View full text Add to dashboard Cite

Size exclusion chromatography coupled with light scattering (SEC/MALS), dynamic light scattering (DLS), steady‐state and time‐resolved fluorescence, as well as molecular dynamics (MD) simulations are used to study the behavior of several poly(ethylene glycol) (PEG)/α‐cyclodextrins (αCDs) polyrotaxanes (PRs) in solution. The number of CD units in any of the PRs studied is always smaller than that required to saturate the PEG chains. These PRs seem to aggregate in dimethyl sulfoxide (DMSO) solution. The presence of hairpins in the non‐saturated PRs contributes to diminishing their expected large dimensions. Intra‐ and intermolecular interactions and forces responsible for hairpins and aggregation are investigated.

show abstract

Section: Introductionmentioning

confidence: 99%

New Insights on the Self‐Organization of PEG/α‐Cyclodextrin‐Based Polyrotaxanes in Solution: An Experimental and Theoretical Study

Peña-Bahamonde

Atencia

Pozuelo

et al. 2013

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

“…Since their discoveries by several groups[87–89], there have been high interests in the development of functional polymer materials and delivery systems based on CDPRs [90–95]. Nevertheless, the applications of CDPR polymers for gene delivery only emerged as a new direction recently.…”

Section: Host-guest Nano-carriers For Gene Deliverymentioning

confidence: 99%

Host–guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications

2010

View full text Add to dashboard Cite

SummarySupramolecular nanostructures assembled by polymeric amphiphiles have been intensively studied during the last two decades. Such nanocarriers may be engineered to possess on-demand bioresponsitivity for the prevention, diagnosis, and treatment of human diseases. The successful development of several nanoassembly-based polymer therapeutics further encouraged scientists to develop nano-vehicles to achieve controlled release, enhanced efficacy, improved specificity and reduced toxicity. Different from the abundant existing literatures on the hydrophobically or electrostatically driven self-assemblies and their therapeutic applications, this article reviews hostguest interaction mediated nanoassemblies, especially those constructed using cyclodextrins as the host entities. The excellent biocompatibility, complexation capacity, and chemical-sensitivity of cyclodextrin make cyclodextrin-containing polymers attractive to construct host-guest nanoassemblies. Such nanocarriers may be advantageous also because of the broad availability of cyclodextrins, their flexibility for structure/property modulation and their chemical-responsive characteristics.

show abstract

“…The position of the hydroxyls in CD results in a ring-shaped, hollow structure with a hydrophobic interior and a hydrophilic exterior, which allows CD molecules to host hydrophobic molecules in the cavity and form inclusion complexes [6][7][8][9][10]. Given this unique property, CDs were extensively studied by numerous researchers and applied in different areas such as foods, pharmacy, cosmetics, and analytical chemistry [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Influence of β-cyclodextrin on morphologies and chemical, thermal, and mechanical properties of non-chain extended polyurethane elastomers

2016

View full text Add to dashboard Cite

A series of polyurethane elastomers (PUEs) were synthesized from an aromatic diisocyanate (4,4′-diphenylmethane diisocyanate (MDI)), a polyether polyol (polytetramethylene glycol; molecular weight: 1000 Da (PTMG1000)), and using β-cyclodextrin (β-CD) as the cross-linker. In this study, we investigated the effects of the addition of β-CD on the morphologies and chemical, thermal, and mechanical properties. The introduction of β-CD in the main chain of PUEs was verified using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and swelling test. The morphology was analyzed through SEM and confocal laser scanning microscopy (CLSM). The results show that the PUEs containing β-CD units exhibited an incompatible microstructure that was improved by the addition of β-CD. The tensile strength of PUEs decreased with the addition of β-CD; however, the elasticity was maintained for <5 % β-CD content. The dynamic mechanical analysis (DMA) and thermogravimetric analysis (TGA) were used to prove the existence of a chemically cross-linked structure and evaluate the thermal stability of PUEs having different β-CD content.

show abstract

Polyrotaxanes

Cited by 25 publications

References 223 publications

New Insights on the Self‐Organization of PEG/α‐Cyclodextrin‐Based Polyrotaxanes in Solution: An Experimental and Theoretical Study

New Insights on the Self‐Organization of PEG/α‐Cyclodextrin‐Based Polyrotaxanes in Solution: An Experimental and Theoretical Study

Host–guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications

Influence of β-cyclodextrin on morphologies and chemical, thermal, and mechanical properties of non-chain extended polyurethane elastomers

Contact Info

Product

Resources

About