Polysaccharide Based Wound Care Materials

Maver, Tina; Maver, Uroš; Pivec, Tanja; Kurečič, Manja; Peršin, Zdenka; Kleinschek, Karin Stana

doi:10.1007/978-3-319-89608-3_2

Cited by 5 publications

(2 citation statements)

References 110 publications

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“…Cs, one of the most promising biopolymers for wound healing, is rarely found in nature, being obtained by deacetylation of chitin [ 52 , 53 ]. Desirable characteristics, such as biodegradability, non-toxicity, low price and biocompatibility, recommend it for regenerative medicine applications, since it facilitates wound closure, supports neovascularization and regeneration of dermis and shows antimicrobial, analgesic and haemostatic activities [ 53 , 54 ].…”

Section: Biopolymers As Tuneable Materialsmentioning

confidence: 99%

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

Gardikiotis

Cojocaru

Mihai

et al. 2022

IJMS

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Wound dressing design is a dynamic and rapidly growing field of the medical wound-care market worldwide. Advances in technology have resulted in the development of a wide range of wound dressings that treat different types of wounds by targeting the four phases of healing. The ideal wound dressing should perform rapid healing; preserve the body’s water content; be oxygen permeable, non-adherent on the wound and hypoallergenic; and provide a barrier against external contaminants—at a reasonable cost and with minimal inconvenience to the patient. Therefore, choosing the best dressing should be based on what the wound needs and what the dressing does to achieve complete regeneration and restoration of the skin’s structure and function. Biopolymers, such as alginate (ALG), chitosan (Cs), collagen (Col), hyaluronic acid (HA) and silk fibroin (SF), are extensively used in wound management due to their biocompatibility, biodegradability and similarity to macromolecules recognized by the human body. However, most of the formulations based on biopolymers still show various issues; thus, strategies to combine them with molecular biology approaches represent the future of wound healing. Therefore, this article provides an overview of biopolymers’ roles in wound physiology as a perspective on the development of a new generation of enhanced, naturally inspired, smart wound dressings based on blood products, stem cells and growth factors.

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Section: Biopolymers As Tuneable Materialsmentioning

confidence: 99%

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

Gardikiotis

Cojocaru

Mihai

et al. 2022

IJMS

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“…Polysaccharides are components that stimulate wound healing and are included in a variety of wound biomaterials 26 . So far, different wound healing effects of many polysaccharides have been proven (modulation of growth factors and cytokines, pro-angiogenic effect, cell proliferation and migration, re-epithelialization, etc.)…”

Section: Introductionmentioning

confidence: 99%

Investigation of multifaceted wound healing effect of exopolysaccharide (EPS) produced from probiotic strain Lactiplantibacillus plantarum GD2 as in vitro and in ovo

Demir,

Aslim

2024

Preprint

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Skin wounds may threaten quality of life and cause serious complications. This study aimed to investigate the effects of lyophilized exopolysaccharide (L-EPS) obtained from the probiotic strain Lactiplantibacillus plantarum GD2 on various stages of wound healing. The results revealed that L-EPS accelerated in vitro wound healing and increased COL1A1 in L929 cells. L-EPS affected the TGF-β1/Smad signaling pathway by increasing the expression of the TGF-β1, Smad2, Smad3, and Smad4 genes. L-EPS also exerted anti-inflammatory effects by reducing the gene expression of IL-1β, IL-6 and iNOS in TNF-α-induced fibroblasts. Additionally, L-EPS demonstrated fibroproliferative effect on both healthy and TNF-α-induced fibroblasts. Furthermore, L-EPS was found to have a proangiogenic effect in ovo chorioallantoic membrane (CAM) model. This study presents the first-ever characterization of the multifaceted effects of L-EPS derived from the probiotic strain L. plantarum GD2 on wound healing. Our findings highlight the potential of L-EPS as effective agent for wound healing and suggest possible application in the development of wound healing biomaterials. By elucidating the mechanism of action of L-EPS in wound healing, this research may provide new perspectives for advanced treatment strategies in the field of wound care.

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The Place of Biomaterials in Wound Healing

Bianchera

Catanzano

Boateng

et al. 2020

Therapeutic Dressings and Wound Healing Applications

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2.1 Background 2.2 Aetiology of Diabetic Foot Ulcers 2.3 Standard of Care for Treatment of Diabetic Foot Ulcers 2.4 Commonly Used Wound Dressings for Diabetic Foot Ulcers and Their Mechanism of Action 2.5 Absorbent and Superabsorbent Dressings 2.6 Alginates 2.7 Films 2.8 Foams 2.9 Honeys 2.10 Hydrogels 2.11 The Role of a Split Thickness Skin Graft in Diabetic Foot Ulcers 2.12 Negative Pressure Wound Therapy 2.13 Larval Therapy 2.14 Clinical Case Studies from Multidisciplinary Diabetic Foot Clinic 2.14.1 Neuropathic Wound 2.14.2 Ischaemic Wound 2.14.3 Neuro-Ischaemic Wound 2.14.4 Osteomyelitis 2.14.5 Charcot's Foot 2.14.6 Necrotising Fasciitis in a Patient with Diabetes 2.15 Summary Acknowledgements References

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Polysaccharide Based Wound Care Materials

Cited by 5 publications

References 110 publications

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

Investigation of multifaceted wound healing effect of exopolysaccharide (EPS) produced from probiotic strain Lactiplantibacillus plantarum GD2 as in vitro and in ovo

The Place of Biomaterials in Wound Healing

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