Polysaccharide isolated from Passiflora edulis: Characterization and antitumor properties

Silva, Draulio C.; Freitas, Ana Lúcia Ponte; Barros, Francisco Clark Nogueira; Lins, Kézia O.A.L.; Alves, Ana Paula Negreiros Nunes; Alencar, Nylane Maria Nunes de; Figueiredo, Ingrid Samantha Tavares de; Pessoa, Cláudia; Moraes, Manoel Odoríco de; Costa-Lotufo, Letı́cia V.; Feitosa, Judith P.A.; Maciel, Jeanny S.; Paula, Regina C.M. de

doi:10.1016/j.carbpol.2011.07.029

Cited by 55 publications

(29 citation statements)

References 29 publications

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“…As a result, the growth of the S180 cells was hardly affected after the cultured cells were exposed to CCPS (at the concentrations from 50 to 800 lg/mL) for 24, 48, and 72 h, respectively, and the maximal inhibition rate of CCPS (800 lg/mL for 72 h) was no more than 15%. As demonstrated for other polysaccharides (Silva et al, 2012), CCPS was not able to effectively inhibit the proliferation of cancer cells in culture.…”

Section: Antitumor Activity Of Ccpsmentioning

confidence: 80%

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Bao

Yuan

Wang

et al. 2014

Pharmaceutical Biology

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Context: Most of the present studies on the antitumor efficiency of Cymbopogon citratus (DC.) Stapf (Gramineae) are limited to its low-mass compounds, and little information about the antitumor activity of polysaccharides from this plant is available. Objectives: This study focused on the potential antitumor and immunomodulatory activities of polysaccharides (CCPS) from C. citratus. Materials and methods: CCPS was isolated using the water extraction-ethanol precipitation method. The sarcoma 180 (S180) cells-inoculated mice were intraperitoneally administrated with CCPS (30-200 mg/kg/d) for seven consecutive days. The effects of CCPS on tumor growth, thymus and spleen weights, splenocyte proliferation, and cytokine secretion in the tumorbearing mice were measured. The cytotoxicity of CCPS (50-800 lg/mL) towards S180 cells was also studied. Results: CCPS significantly inhibited the growth of the transplanted S180 tumors, with the inhibition rates ranging from 14.8 to 37.8%. Simultaneously, CCPS dose-dependently improved the immunity of the tumor-bearing mice. With the highest dose of 200 mg/kg/d, the thymus and spleen indices were increased by 21.9 and 91.9%, respectively; ConA-and LSP-induced splenocyte proliferations were increased by 32.7 and 35.3%, respectively. The secretions of interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 2 (IL-12), and tumor necrosis factor-a (TNF-a) were increased by 103.2, 40.2, 23.6, and 26.3%, respectively. Nevertheless, almost no toxicity of CCPS towards S180 cells was observed, with the maximal inhibition rate less than 15% at the CCPS concentration of 800 lg/mL. Conclusion: CCPS exhibited antitumor activity in vivo, and this activity might be achieved by immunoenhancement rather than direct cytotoxicity.

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Section: Antitumor Activity Of Ccpsmentioning

confidence: 80%

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Bao

Yuan

Wang

et al. 2014

Pharmaceutical Biology

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“…Since then, various type of polysacchairdes have shown promising potential as antitumor agents (Jin et al, 2014;Silva et al, 2012;Sun, 2011). Pectin, structurally and functionally the most complex polysaccharide in plant cell walls, is a family of galacturonic acid-rich polysaccharides including homogalacturonan (HG), rhamnogalacturonan I (RG-I), and the substituted galacturonans, such as rhamnogalacturonan II (RG-II), and xylogalacturonan (XGA) (Mohnen, 2008).…”

Section: Hrwp-a Has No Direct Cytotoxicity On Llc1 Cellsmentioning

confidence: 99%

“…The activity of polysaccharides might be caused and influenced by their glycosidic linkages, chain length, the number of branched points, molecular size and tertiary structure (Raveendran Nair et al, 2004). The unique structure diversities and physiochemical properties can be utilized successfully in various medical applications, and many polysaccharides have shown promising potential as antitumor agents, such as ␤-glucans, amylopectin-like polysaccharides and pectins (Brown, 2006;Cao, 2013;Jin, Zhao, Huang, & Shang, 2014;Silva et al, 2012;Sun, 2011). These polysaccharides usually have low toxicity and few side effects, which make them appropriate for immunotherapy against tumors.…”

Section: Introductionmentioning

confidence: 99%

Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Wang

Gao

et al. 2015

Carbohydrate Polymers

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“…Furthermore, enzymatically purified okra pod RG-I, carrying short galactan side chains, also exhibited antiproliferative and proapoptotic activities (Vayssade et al 2010), and hot water-extracted galactan-rich RG-I fractions from various plant materials such as yellow passion fruit rind, banana peel, and tobacco leaf showed efficacious antiproliferative activities in vitro (Yapo 2011a;Silva et al 2012). Moreover, specific binding of pectin galactans to galectin-3 has been reported (Gunning et al 2009).…”

Section: Anticancer Properties Of Pectinsmentioning

confidence: 90%

Pectic Polysaccharides and Their Functional Properties

Yapo¹,

Gnakri²

2015

Polysaccharides

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Polysaccharide isolated from Passiflora edulis: Characterization and antitumor properties

Cited by 55 publications

References 29 publications

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Pectic Polysaccharides and Their Functional Properties

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