Polysaccharide of <i>Lactobacillus casei</i> SB27 reduced colon cancer cell prognosis through mitochondrial damage by upregulation of HINT2

Di, Wei; Li, Xin; Yang, Qiaoyi

doi:10.1111/ajco.13876

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Current evidence suggests that COA6 is associated with tumor progression and signi cant adverse survival in patients with lung cancer, hepatocellular carcinoma, and colon cancer [47][48][49]. Moreover, HINT2 (histidine triad nucleotide-binding protein 2) is extensively involved in cell energy metabolism [50] and the pathogenesis of various malignant tumors, such as endometrial and colorectal cancer [51,52]. It has been found that HINT2 could induce apoptosis of tumor cells through mitochondrial-related pathways and also played an important role in promoting tumor proliferation and migration by downregulating the expression of HINT2, thus leading to poor prognosis of patients [53].…”

Section: Discussionmentioning

confidence: 99%

Construction of a mitochondria genes-based model for prognosis prediction, drug guidance and immune feature analysis in ovarian serous cystadenocarcinoma

Shen

Ding

et al. 2023

Preprint

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Background Ovarian serous cystadenocarcinoma (OSC) is the most common pathological subtype of ovarian cancer (OC) associated with high mortality. Albeit dysregulated mitochondrial metabolism has been implicated with OC, the role of mitochondrial genes in OSC remains unclear. We sought to construct a model based on mitochondrial genes for prognosis prediction, drug guidance and immune feature analysis of OSC. Methods Differentially expressed genes (DEGs) and mitochondrial-related DEGs (MRGs) were identified through the Cancer Genome Atlas (TCGA)-OV dataset. Consensus clustering algorithm was applied to classify OSC patients into distinct MRGs subtypes. Prognosis-related MRGs were screened to construct the prognosis-related Risk score model, which was verified using GSE26193 dataset and immunohistochemistry (IHC) score model based on staining intensity and extent scores of MRGs. A visualized nomogram was developed to predict 1-, 3- and 5-year overall survival (OS) and drug response. The correlation of MRGs subtypes with risk subgroups and the association of Risk score model with immune response and infiltration were also investigated. Results 341 MRGs were identified from TCGA-OV, and OSC patients could be mainly divided into two MRGs subtypes. A novel prognostic Risk score model based on 7-MRGs, including ACOT13, ACSS3, COA6, HINT2, MRPL14, NDUFC2 and NDUFV2, was developed and validated via GSE26193 dataset and IHC score model. Patients in the low-risk group had a significantly longer OS. The nomogram exhibited good prognostic assessment accuracy in both training and validation datasets. Drug sensitivity analysis indicated that cisplatin, paclitaxel and docetaxel were more sensitive in the low-risk group; VEGFR inhibitor Axitinib, and BRAF inhibitors Vemurafenib and SB590885 showed better sensitivity in the high-risk group; moreover, patients in the low-risk group could have better anti-PD-1 immunotherapy response. Patients in “cluster1” MRGs subtype had lower risk scores and better immunotherapy response scores than the “cluster2” subgroup. More significant infiltrated tumor killing cells (CD8+ T cells) and higher M1 / M2 macrophage ratio were in “cluster1” patients. Conclusions Our novel 7 MRGs-based Risk score model has huge prospects to evaluate the prognosis and guide drug treatment. The favorable prognosis associated with the low-risk group is closely related to better immune response and more significant anti-tumor cellular infiltration.

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Section: Discussionmentioning

confidence: 99%

Construction of a mitochondria genes-based model for prognosis prediction, drug guidance and immune feature analysis in ovarian serous cystadenocarcinoma

Shen

Ding

et al. 2023

Preprint

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“…The preliminary evidence of the inflammation-reducing effects of EPS-J12 has been established. However, further research is required to determine whether it exerts an anticancer effect, whether it is regulated through a signalling pathway, and whether it exerts an effect on mitochondria 34 or is associated with the growth and spread of cancerous cells 35 .…”

Section: The Expression Level Of Il-12amentioning

confidence: 99%

Exploring the Therapeutic Potential of Paenibacillus-Derived Exopolysaccharides in Colorectal Cancer: A Cellular and Inflammatory Perspective

Luo

2024

BIO Web Conf.

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This study seeks to explore the possibility of discovering a novel therapeutic agent for colorectal cancer. The exopolysaccharide (EPS-J12) from Paenibacillus spp. PYQ-J12 was used as the experimental subject. Caco-2 cells were used to simulate impaired intestinal epithelial cells, and TNF-α was used to cause inflammation of the cells, which was expected to investigate the reparative functions of EPS on inflamed, damaged Caco-2 cells and its influence on the expression levels of different inflammatory factors. Cell viability was used as an indicator to evaluate the reparative effects of the polysaccharide. The expression levels of different cytokines, including Interleukin 6 (IL-6), IL-8, IL-10, IL-1β, and Interleukin 12A (IL-12A), were tested. The findings indicated that EPS has a certain repair effect on inflammatory damage and can cause a reduction in the expression levels of inflammatory factors, thereby controlling inflammation. Therefore, it has the potential to become a new therapeutic option.

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“…In a recent report by Di et al . (2023), it was revealed that the EPS of L. casei SB27 effectively reduces colon cancer cells. So, the primary objective of our study was to concentrate on the production of camel milk yoghurt, using probiotic bacteria isolated from dairy products, that had the capability to produce higher quantities of EPS.…”

Section: Introductionmentioning

confidence: 98%

Utilisation of Lacticaseibacillus casei ATCC 393‐derived exopolysaccharide for camel milk yoghurt production and its potential anticancer and hepatoprotective properties

Ali,

Darwish,

Hassan

et al. 2024

Int J of Dairy Tech

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Camel milk yoghurts were created using probiotic lactic acid bacteria (LAB) with exopolysaccharide (EPS) production capabilities. Lacticaseibacillus casei ATCC 393, identified as the most efficient EPS producer, was incorporated into conventional yoghurt culture. We compared the effects of adding L. casei ATCC 393 with EPS powder (SLLP) against lactulose. Evaluations included LAB, yeast, mould, cytotoxicity and IC50 values in the samples. The results demonstrated increased bacterial counts, LAB viability, viscosity, antiproliferative effects and a lower IC50 in SLLP, indicating the potential application of EPS‐producing L. casei ATCC 393 and its derived EPS in the development of functional foods.

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Polysaccharide of Lactobacillus casei SB27 reduced colon cancer cell prognosis through mitochondrial damage by upregulation of HINT2

Cited by 5 publications

References 31 publications

Construction of a mitochondria genes-based model for prognosis prediction, drug guidance and immune feature analysis in ovarian serous cystadenocarcinoma

Construction of a mitochondria genes-based model for prognosis prediction, drug guidance and immune feature analysis in ovarian serous cystadenocarcinoma

Exploring the Therapeutic Potential of Paenibacillus-Derived Exopolysaccharides in Colorectal Cancer: A Cellular and Inflammatory Perspective

Utilisation of Lacticaseibacillus casei ATCC 393‐derived exopolysaccharide for camel milk yoghurt production and its potential anticancer and hepatoprotective properties

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