Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication

Демина, Т. С.; Kilyashova, Liubov A.; Popyrina, Tatiana N.; Svidchenko, Evgeniya A.; Bhuniya, Sankarprasad; Акопова, Т. А.; Grandfils, Christian

doi:10.3390/polym13183045

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…To solve these issues, pickering particles or a mix of surfactants and gelling agents (to stabilize the inner or outer emulsion or gel the water phase or crystallize the fat phase) may be used [5]. Therefore, most recent research has focused on formulating double emulsions stabilized by biopolymers [6], such as milk protein concentrate [7], sodium caseinate [8], peanut protein isolate, rice bran protein isolate, soybean protein isolate, whey protein isolate [9], sodium caseinate and k-carrageenan [10], alginate [11], chitosan, cellulose, arabinogalactan, guar and their derivatives [12], calcium alginate [13] and xanthan gum [14,15].…”

Section: Introductionmentioning

confidence: 99%

Preparation of vitamin D3-loaded oil-in-water-in-oil double emulsions using psyllium gum: optimization using response surface methodology

Didar

Hesarinejad²

2022

Chem. Biol. Technol. Agric.

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In this study, the encapsulation of vitamin D3 into a double emulsion with psyllium gum in the aqueous phase and lecithin in the oil phase was optimized and modeled. The optimal values of the three independent variables were generated using a faced-centered central composite design (FCCD). The Z-average (diameter of the emulsion droplets), polydispersity index (PDI), zeta potential, interfacial tension, creaming index, and encapsulation efficiency are among the quality evaluation metrics. According to the findings, the Z-average in the double emulsion was inversely affected by the psyllium gum concentration. The findings indicated that time after production had a significant direct influence on the Z-average. All freshly manufactured formulations may be characterized as good stable emulsions, according to the measurement of double emulsions’ zeta potential after preparation (negative charge lower than − 40.1 mV). During storage, the zeta potential value exhibited an upward trend. The creaming index was influenced significantly by storage time (p < 0.05) and at the end of storage time, the creaming index was 19.2% (in the sample with no gum and containing 0.25% lecithin). Analysis revealed that the interfacial tension was reduced as a result of the inclusion of the psyllium gum. On the other hand, prolonging storage lengthened the interfacial tension's magnitude. According to the findings, gum content and time had a significant impact on the encapsulation efficiency of primary and double emulsions. Finally, the optimal double emulsion preparation parameters based on maximum encapsulation efficiency were 1% psyllium gum, 1.125% lecithin, and a storage time equal to 25 days at 8 °C, with an obtained encapsulation efficiency of the double emulsion of 93.26%.

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Section: Introductionmentioning

confidence: 99%

Preparation of vitamin D3-loaded oil-in-water-in-oil double emulsions using psyllium gum: optimization using response surface methodology

Didar

Hesarinejad²

2022

Chem. Biol. Technol. Agric.

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“…Previous studies have reported the synthesis of HPS-DDS, such as nanoparticles (NPs) [25,26], micelles [27], liposomes [28], microemulsions [29], hydrogels [30], and microneedles [31], for the treatment of various diseases. These studies show that HPS can serve as drug carriers [32], stabilizers [33], solubilizers [34], and emulsifiers [35]. Considering their bioactivity, these HPS can also act as adjuvants [36], immunomodulators [37], and bioactive macromolecular drugs [38] that exert synergistic effects or amplify the therapeutic activities of primary drugs.…”

Section: Introductionmentioning

confidence: 98%

Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy

et al. 2022

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Herb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weight, and functional group profile, HPS can be conjugated, cross-linked, and functionally modified. Thus, they are great candidates for the fabrication of drug delivery systems (DDS). HPS-based DDS (HPS-DDS) can bypass phagocytosis by the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting therapeutic effects. In this review, we focus on the application of HPS as components of immunoregulatory DDS. We summarize the principles governing the fabrication of HPS-DDS, including nanoparticles, micelles, liposomes, microemulsions, hydrogels, and microneedles. In addition, we discuss the role of HPS in DDS for immunotherapy. This comprehensive review provides valuable insights that could guide the design of effective HPS-DDS.

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“…This approach relies on the stabilization of the oil/water interface by nHA dispersed within the aqueous phase, while the oil one consists of polyester solution. Solid nanoparticles of various nature could stabilize the emulsion interface even more effectively than molecular surfactants [ 31 , 32 , 33 ]. It allows to avoid the usage of additional emulsifiers and to fabricate nHA-armored polyester core/shell microparticles.…”

Section: Introductionmentioning

confidence: 99%

Controlled Structure of Polyester/Hydroxyapatite Microparticles Fabricated via Pickering Emulsion Approach

et al. 2022

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Biodegradable polyester/hydroxyapatite microparticles are widely proposed as microcarriers for drug/cell delivery or scaffolds for bone tissue regeneration. The current research implements the surfactant-free approach for the fabrication of polyester-based microparticles filled with hydroxyapatite nanoparticles (nHA) via the oil/water Pickering emulsion solvent evaporation technique for the first time, to the best of our knowledge. The process of polyester microparticle fabrication using nHA for the oil/water interface stabilization was studied as a function of phase used for nHA addition, which allows the preparation of a range of microparticles either filled with nHA or having it as a shell over the polymeric core. The effect of processing conditions (polymer nature, polymer/nHA ratio, ultrasound treatment) on particles’ total yield, size distribution, surface and volume morphology, and chemical structure was analyzed using SEM, EDX, Raman spectroscopy, and mapping. Addition of nHA either within the aqueous or oil phase allowed the effective stabilization of the oil/water interface without additional molecular surfactants, giving rise to hybrid microparticles in which total yield, size distribution, and surface morphology depended on all studied processing conditions. Preliminary ultrasound treatment of any phase before the emulsification process led to a complex effect but did not affect the homogeneity of nHA distribution within the polymeric core of the hybrid microparticles.

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Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication

Cited by 7 publications

References 38 publications

Preparation of vitamin D3-loaded oil-in-water-in-oil double emulsions using psyllium gum: optimization using response surface methodology

Preparation of vitamin D3-loaded oil-in-water-in-oil double emulsions using psyllium gum: optimization using response surface methodology

Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy

Controlled Structure of Polyester/Hydroxyapatite Microparticles Fabricated via Pickering Emulsion Approach

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