Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities

Chen, Nana; Zhang, Hao; Zong, Xin; Li, Siyu; Wang, Jiaojiao; Wang, Yizhen; Jin, Mingliang

doi:10.1016/j.carbpol.2020.116750

Cited by 78 publications

(27 citation statements)

References 162 publications

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“…Scientific advances have proven that polysaccharides have various biological activities including antioxidant activity, up-regulation of immunity, anticancer activity antiviral activity and etc., with less adverse effects (Chen, Zhang, et al. 2020 ; Gu et al. 2020 ; Dong, Hou et al.…”

Section: Antiviral Constituents In Traditional Chinese Medicinesmentioning

confidence: 99%

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Chen

2022

Pharmaceutical Biology

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Context Viruses have the characteristics of rapid transmission and high mortality. At present, western medicines still lack an ideal antiviral. As natural products, many traditional Chinese medicines (TCM) have certain inhibitory effects on viruses, which has become the hotspot of medical research in recent years. Objective The antiviral active ingredients and mechanisms of TCM against viral diseases was studied in combination with the pathogenesis of viral diseases and antiviral effects. Materials and methods English and Chinese literature from 1999 to 2021 was collected from databases including Web of Science, PubMed, Elsevier, Chinese Pharmacopoeia 2020 (CP), and CNKI (Chinese). Traditional Chinese medicines (TCM), active ingredients, antiviral, mechanism of action, and anti-inflammatory effect were used as the key words. Results The antiviral activity of TCM is clarified to put forward a strategy for discovering active compounds against viruses, and provide reference for screening antivirus drugs from TCM. TCM can not only directly kill viruses and inhibit the proliferation of viruses in cells, but also prevent viruses from infecting cells and causing cytophilia. It can also regulate the human immune system, enhance human immunity, and play an indirect antiviral role. Discussion and conclusion Based on the experimental study and antiviral mechanism of TCM, this paper can provide analytical evidence that supports the effectiveness of TCM in treating virus infections, as well as their mechanisms against viruses. It could be helpful to provide reference for the research and development of innovative TCMs with multiple components, multiple targets and low toxicity.

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Section: Antiviral Constituents In Traditional Chinese Medicinesmentioning

confidence: 99%

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Chen

2022

Pharmaceutical Biology

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“…Except for the northeast region, the Qinba mountainous area in Shaanxi Province has dense forests, sufficient sunlight, a humid climate, and a large temperature difference between day and night in summer and autumn, which are suitable conditions for the growth of Auricularia auricula-judae . Polysaccharides are one of the most important active components in the fruiting body of Auricularia auricula-judae , which promotes antioxidant, immunomodulatory, antitumor, anticoagulant, antifatigue, and other activities [ 7 , 8 ]. Studies have found that Auricularia auricula-judae and its polysaccharides can reduce serum triglycerides and cholesterol [ 9 , 10 , 11 ], but the molecular mechanism of its influence on lipid metabolism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Auricularia auricula-judae Polysaccharides Alleviate Nutritional Obesity in Mice via Regulating Inflammatory Response and Lipid Metabolism

Liu

et al. 2022

Foods

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The incidence of lipid metabolism disorder and obesity that is caused by high-calorie diets is increasing year by year, which has become an urgent global health problem. This study was performed to explore the intervention effects of polysaccharides that were extracted from Auricularia auricula-judae resources in the Qinba Mountain area on nutritional obesity in C57BL/6J mice that was induced by high fat and high fructose diets (HFFD) and to investigate their underlying molecular mechanisms. The results showed that dietary supplementation of Auricularia auricula-judae polysaccharides (AAP) significantly improved mice’s insulin resistance state, altered serum lipid metabolites, and slowed down body weight gain that was induced by HFFD. In addition, AAP supplementation decreased inflammatory factor levels and alleviated liver histomorphology changes. Furthermore, AAP down-regulated liver adipogenic-related gene expressions, suppressed cholesterol synthesis-related gene levels, up-regulated fatty acid β-oxidation-related gene expressions, and promoted cholesterol efflux-related gene expressions, thus improving mice hepatic lipid metabolism homeostasis. Moreover, the intervention effects were closely related to mitochondrial function. These results provide a scientific basis for the further development and utilization of Auricularia auricula-judae resources in the Qinba Mountain area.

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“…As a natural compound, plant polysaccharide, was widely studied in aspects of antioxidant, anti‐inflammatory, improving immunity with less toxicity, [6,7] and it has become a hotspot for cancer treatment [8] . Polysaccharides isolated from A. sinensis have been proved to mainly contain glucose and galactose, and exhibit a series of biological functions such as antioxidant, hepatoprotective and immune activities [9,10,11] .…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization of an Alkali‐Soluble Polysaccharide from Angelica sinensis and Its Antitumor Activity in Vivo

Zhao

Feng

Xue

et al. 2021

Chemistry & Biodiversity

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A novel alkali‐soluble polysaccharide (AASP) was isolated from Angelica sinensis (Oliv.) Diels under aqueous alkali treatment, and its structural characterization and antitumor activity in Vivo were evaluated in present study. Results of HPGPC and IC revealed that AASP was a neutral polysaccharide containing Ara, Gal and Glc in the mole ratio of 1.00 : 2.26 : 24.43, with the average molecular weight of 4.7 kDa. Periodate oxidation, Smith degradation, methylation, FT‐IR, and NMR analyses further demonstrated that a preliminary structure of AASP was proposed as follows: (1→3)‐linked arabinose, (1→6)‐linked galactose, and (1→), (1→4), (1→6), (1→3,6)‐linked glucose with α‐ and β‐configuration. In Vivo antitumor assays, AASP exhibited prominent antitumor effects on H22 hepatoma cells with an inhibitory ratio of 48.57 % and effectively protected thymuses and spleens of tumor‐bearing mice. Besides, AASP displayed a proliferation stimulating activity of immunocytes (splenocytes, peritoneal macrophages and natural killer cells), and an auxo‐action for cytokines release (TNF‐α, IL‐2 and IFN‐γ), leading to the apoptosis of H22 solid tumors cells via G0/G1 phase arrested. The above data demonstrated that AASP holds great application potential to be a safe and effective antitumor supplement in the future.

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Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities

Cited by 78 publications

References 162 publications

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Dietary Supplementation of Auricularia auricula-judae Polysaccharides Alleviate Nutritional Obesity in Mice via Regulating Inflammatory Response and Lipid Metabolism

Structural Characterization of an Alkali‐Soluble Polysaccharide from Angelica sinensis and Its Antitumor Activity in Vivo

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