Polysaccharides from Ganoderma formosanum function as a Th1 adjuvant and stimulate cytotoxic T cell response in vivo

Pi, Chia-Chen; Chu, Chih‐Liang; Lu, Chu-Ying; Zhuang, Yu-Jing; Wang, Cheng-Li; Yu, Yi‐Hsien; Wang, Hui-Yi; Lin, Chih-Chung; Chen, Chun‐Jen

doi:10.1016/j.vaccine.2013.11.027

Cited by 30 publications

(21 citation statements)

References 39 publications

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“…PS-F2 administration during the course of chicken ovalbumin (OVA) sensitization and challenge effectively prevented AHR development, OVA-specific IgE and IgG1 production, bronchial inflammation, and Th2 cytokine production. Hence, PS-F2 has a potential to be used for the prevention of allergic asthma (Pi et al 2014a).…”

Section: Ganoderma Calidophilum G Carnosum G Chalceum and G Concmentioning

confidence: 99%

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Hapuarachchi¹

2017

Mycosphere

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The genus Ganoderma (Ganodermataceae) has a long history in traditional medicine to improve longevity and health in Asia. Ganoderma has been widely used in multiple therapeutic activities as well as dietary supplements to prevent and treat many diseases. Several classes of bioactive substances have been isolated and identified from Ganoderma, such as polysaccharides, triterpenoids, nucleosides, sterols, fatty acids, protein and alkaloids. There are numerous research publications, which report the abundance and variety of biological actions initiated by the metabolites of Ganoderma. Investigation on different metabolic activities of Ganoderma species has been performed both in vitro and in vivo. In many cases, however, it has been questioned whether Ganoderma is solely a nourishment supplement for wellbeing or merely a helpful "medication" for restorative purposes. There has been no any conclusive report of human trials using Ganoderma species as a direct control agent for diseases. In addition, there is no evidence supporting the usage of Ganoderma species (excluding G. lucidum) as potential supplements for cancer or other diseases in humans since no preclinical trials have been performed up to date. In this review, the beneficial medicinal properties of several species of Ganoderma (excluding G. lucidum) and their secondary metabolites are discussed. Ganoderma species can be used as a therapeutic drug, but more direct scientific evidence should be made available in the future. The efficiency of Ganoderma in clinical treatments should be substantiated with more biomedical research and their true impact assessed on human health with more standardized clinical evaluations so that the feasibility of biologically active extracts of Ganoderma species in alternative treatments can be recommended.

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Section: Ganoderma Calidophilum G Carnosum G Chalceum and G Concmentioning

confidence: 99%

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Hapuarachchi¹

2017

Mycosphere

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“…have been isolated and evaluated, such as polysaccharides (Pi et al 2014; Zhang, Nie, et al 2014; Zhu et al 2016), triterpenoids (Zhang, Tao, et al 2014; Peng et al 2015; Smina et al 2016), immune-modulating proteins (Guan et al 2014; Lin et al 2014), steroids (Ko et al 2008; Seo et al 2009), and alkaloids (Zhao et al 2015; Huang et al 2016). Scientists at IMCAS also conducted the chemical analysis and evaluation of components from interested Ganoderma species, so as to reveal their application potential.…”

Section: Research On Ling-zhimentioning

confidence: 99%

Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS)

Dong

Wen

et al. 2016

Mycology

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Ling-zhi is a medicinal herb that generally refers to a fungus in the genus Ganoderma. It has been used as a medicinal mushroom in traditional Chinese medicine for more than 2000 years. Mycologists at the Institute of Microbiology, Chinese Academy of Sciences (IMCAS) first artificially cultivated the Ling-zhi fruiting body in the late 1960s (X.J. Liu’s team). In IMCAS, different research teams have extensively studied Ling-zhi in the aspects of national resource surveys, systematic taxonomy, chemical analysis, and processing for medicinal and health applications. The research results from IMCAS have provided essential support and prompted the development of the Ling-zhi industry in China to some extent. This review aims to summarize the history of research on Ling-zhi in IMCAS and its role in the development of the Ling-zhi economy.

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“…Polysaccharides (PSs) extracted from Ganoderma lucidum were shown to activate the host immune system, leading to the production of various T-helper 1 (T h 1)-biased cytokines, 12 which indicates the potential of immunostimulants. However, the PSs also have some disadvantages, such as having a nonfocused action scope, being dependent on large doses, and having a brief biological half-life, which may limit future applications.…”

Section: Introductionmentioning

confidence: 99%

Cubosome nanoparticles potentiate immune properties of immunostimulants

Liu

Luo

Zheng

et al. 2016

IJN

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Cubosomes have been explored as drug and antigen carriers in the past few years. A few reports have described that cubosomes can enhance the ability of immunostimulants to generate strong immune responses. Polysaccharide (PS), an immunostimulant, has been reported to be a promising adjuvant for vaccines. Herein, we incorporated PS into cubosomes to generate PS–cubosome (Cub-PS) nanoparticles, and Cub-PS was characterized by small-angle X-ray scattering scattering and cryo-field emission scanning electron microscopy. The immunological activity of Cub-PS was compared with that of Cub and PS. The results demonstrated that Cub-PS elicited more potent immune responses than Cub or PS alone. The enhanced immune responses might be attributed to the promotion of antigen transport into draining lymph nodes and efficient dendritic cell activation and memory T-helper cell differentiation in draining lymph nodes. Overall, these findings indicate that cubosomes have the potential to enhance the ability of immunostimulants to generate an immune response.

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Polysaccharides from Ganoderma formosanum function as a Th1 adjuvant and stimulate cytotoxic T cell response in vivo

Cited by 30 publications

References 39 publications

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS)

Cubosome nanoparticles potentiate immune properties of immunostimulants

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