Polysarcosine brush stabilized gold nanorods for in vivo near-infrared photothermal tumor therapy

Zhu, Hong; Chen, Ying; Yan, Fang-Jie; Chen, Jin; Tao, Xinfeng; Ling, Jun; Yang, Bo; He, Qiaojun; Mao, Zhengwei

doi:10.1016/j.actbio.2016.12.050

Cited by 67 publications

(41 citation statements)

References 65 publications

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“…This contrasts to the large literature on, e.g., thermoresponsive poly( N ‐isopropylacrylamide) brushes or on polypeptide‐modified nanomaterials . To the best of our knowledge only three examples of polypeptoid‐modified nanoparticles have been published, reporting on “grafting‐to” of poly( N ‐methylglycine) (PNMG) on CdSe quantum dots, gold nanoparticles, and gold nanorods, demonstrating a huge gap both in terms of demonstration of synthesis of polypeptoid brushes on nanostructures and in terms of characterization of the tunable colloidal properties of polypeptoid‐stabilized nanomaterials.…”

Section: Introductionmentioning

confidence: 85%

Thermoresponsive Polypeptoid‐Coated Superparamagnetic Iron Oxide Nanoparticles by Surface‐Initiated Polymerization

Kurzhals

Pretzner

Reimhult

et al. 2017

Macro Chemistry & Physics

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Thermoresponsive polypeptoids are promising candidates for medical applications due to their biomimetic properties. When such polymers are grafted on magnetic nanoparticles, materials can be obtained that combine a temperature-triggered solubility transition with magnetic extraction. The synthesis of monodisperse, superparamagnetic iron oxide nanoparticles is described with densely surface-grafted polypeptoid shells that have tunable thermoresponsive colloidal stability. The synthesis combines ligand exchange with controlled surface-initiated polymerization of N-substituted N-carboxyanhydrides for the preparation of well-defined core-shell nanoparticles.

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Section: Introductionmentioning

confidence: 85%

Thermoresponsive Polypeptoid‐Coated Superparamagnetic Iron Oxide Nanoparticles by Surface‐Initiated Polymerization

Kurzhals

Pretzner

Reimhult

et al. 2017

Macro Chemistry & Physics

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“…However, there are still several bottleneck problems to be addressed, including multidrug resistance, undesirable side effects, heterogeneity, and poor permeability [4][5][6][7]. Recently, nanoparticle (NP)-mediated photothermal therapy (PTT) has attracted considerable attention due to thermal elimination of tumor cells by the localized conversion of near infrared (NIR) light into heat [8,9]. PTT reveals rapid, efficient, and minimally invasive capacities compared with other approaches.…”

Section: Introductionmentioning

confidence: 99%

Macrophages loaded CpG and GNR-PEI for combination of tumor photothermal therapy and immunotherapy

et al. 2018

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Nano-therapeutic approach for clinical implementation of tumors remains a longstanding challenge in the medical field. The main challenges are rapid clearance, offtarget effect and the limited role in the treatment of metastatic tumors. Toward this objective, a cell-mediated strategy by transporting photothermal reagents and CpG adjuvant within macrophage vehicles is performed. The photothermal reagents are constructed by conjugating of hyperbranched polyethyleimine (PEI) to golden nanorode (GNR) via S-Au bonds. GNR-PEI/CpG nanocomposites, formed via electrostatic interaction and displayed excellent near-infrared (NIR) photothermal performance, exhibit immense macrophage uptake and negligible cytotoxic effect, which is essential for the fabrication of GNR-PEI/CpG loaded macrophages. GNR-PEI/ CpG loaded macrophages demonstrated admirable photothermal response in vitro. Benefited from the functionalization of the binding adhesion between macrophages and 4T1 cells, GNR-PEI/CpG loaded macrophages significantly promoted tumor accumulation in vivo and dramatically enhanced the efficiency of photothermal cancer therapy. Moreover, the immune system is activated after photothermal therapy, which is mainly attributed to the generation of tumor specific antigens and CpG adjuvant in situ. Our findings provide a potential cell-mediated nanoplatform for tumor therapy by combination of near infrared photothermal therapy and immunotherapy.

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“…Zhu et al () used disulfide polysarcosine (PS) with optimized molecular weight to modify AuNRs by the traditional ligand exchange method. The PS coated AuNRs (AuNR@PS) showed excellent stability in wide pH ranges and strong resistance to ligand competition with DTT.…”

Section: Organic Polymersmentioning

confidence: 99%

“…Various conditions that are likely to influence the cytotoxicity concerning cell lines, concentration of modified AuNRs, and incubation time are all taken into consideration. Summarized from (Duan et al, 2015;Kaneti et al, 2015;Kirui, Krishnan, including Strickland, & Batt, 2011;Liu et al, 2014;Liu et al, 2017;Manivasagan et al, 2017;Pan et al, 2016;Zhang et al, 2016;Zhu et al, 2016) In the last several years, imaging-guided therapy is becoming increasingly popular. The combination with imaging agents bridges diagnosis and therapeutics, providing an insight for cancer heterogeneity and adaptation.…”

Section: Synthetic Polymers 211 | Polyethyleneglycolmentioning

confidence: 99%

Detoxification and functionalization of gold nanorods with organic polymers and their applications in cancer photothermal therapy

Jin

Zhang

Yang

et al. 2019

Microscopy Res & Technique

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Gold nanorods (AuNRs) have attracted widespread attention in the last few decades due to their potential applications in cancer photothermal therapy (CPTT). However, the utilization of AuNRs is restricted because of their high toxicity for cells and tissues. Numerous methods have been developed to solve this problem, among which the most convenient one is to coat AuNRs with biocompatible materials or replace their original toxic surfactant such as the hexadecyl‐trimethyl ammonium bromide (CTAB). Organic polymers (OPs) are intensively researched due to their low toxicity and easy access to modification with functional groups (e.g., targeting molecules), pharmaceuticals (e.g., chemo drugs) and imaging agents (e.g., radioactive elements). Herein, this mini review summarized recent progress in detoxification and functionalization of AuNRs exploiting OPs coatings and their applications in CPTT. To begin with, we introduced current major approaches used to modify AuNRs with typical OPs. Then, applications of OPs coated AuNRs in CPTT were discussed. At the end of the review, we proposed a brief outlook for the future development of modification and functionalization of AuNRs with organic materials.

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Polysarcosine brush stabilized gold nanorods for in vivo near-infrared photothermal tumor therapy

Cited by 67 publications

References 65 publications

Thermoresponsive Polypeptoid‐Coated Superparamagnetic Iron Oxide Nanoparticles by Surface‐Initiated Polymerization

Thermoresponsive Polypeptoid‐Coated Superparamagnetic Iron Oxide Nanoparticles by Surface‐Initiated Polymerization

Macrophages loaded CpG and GNR-PEI for combination of tumor photothermal therapy and immunotherapy

Detoxification and functionalization of gold nanorods with organic polymers and their applications in cancer photothermal therapy

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