2022
DOI: 10.1016/j.brainres.2022.147786
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Polysorbate-coated mesoporous silica nanoparticles as an efficient carrier for improved rivastigmine brain delivery

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Cited by 22 publications
(13 citation statements)
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“…Analysis with HPLC idenitfied excellent-fitting linear responses ( R 2 > 0.99) for the buffer solutions, plasma, and brain homogenate over the concentration range of 50–4000 ng/mL. , The peak of MTX appeared at 5.2 min in the chromatogram. The LOD and LOQ values in buffer solutions were 22 and 73.1 ng/mL, respectively.…”
Section: Results and Discussionmentioning
confidence: 88%
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“…Analysis with HPLC idenitfied excellent-fitting linear responses ( R 2 > 0.99) for the buffer solutions, plasma, and brain homogenate over the concentration range of 50–4000 ng/mL. , The peak of MTX appeared at 5.2 min in the chromatogram. The LOD and LOQ values in buffer solutions were 22 and 73.1 ng/mL, respectively.…”
Section: Results and Discussionmentioning
confidence: 88%
“…Among these entities, MSNs have received great interest as drug carriers because of their biocompatibility, capability for facile surface modification via their silanol groups, as well as their amenability to control particle size and pore size. , The authors’ prior research in 2021 showed that polysorbate-coated MSNs could bypass the BBB and deliver rivastigmine, an anti-Alzheimer drug, into the brain. Nuropharmacokinetic studies confirmed that the brain uptake clearance of the rivastigmine-loaded MSNs was significantly higher than the free drug . This study highlighted the importance of surface functionalization of MSNs to enable them to function as effective drug carriers for delivery to the brain. , In the same year, angiopep-2 modified lipid-coated MSNs were introduced for glioma treatment.…”
Section: Introductionmentioning
confidence: 71%
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“…PLGA exhibits the characteristic peak at 1745 cm –1 assigned to CC bonds, which is also present in both C1 and C2 particles. RIV exhibits peaks at 1727 cm –1 and at 1409 and 1462 cm –1 , which are attributed to the carboxyl group of the ester bond and the tensile absorptions of CC bonds in the aromatic ring, respectively . The spectrum of NAC shows a peak at 2549 cm –1 , which corresponds to the S–H stretching vibration .…”
Section: Resultsmentioning
confidence: 99%
“…Notably, these ligands were more efficient than the transferring molecules, which would be considered an excellent choice for delivering the theranostics to the brain through the blood–brain barrier. Recently, polysorbate 80-immobilized, calcium-doped MSNs were employed to deliver rivastigmine to brain [ 330 ]. These nanosystems with excellent compatibility in blood and brain cells presented improved pharmacokinetics, exhibiting better brain uptake clearance of the designed nanocomposites compared to free drug.…”
Section: Biomedical Applicationsmentioning
confidence: 99%