Polysplenia Syndrome With Splenic and Skeletal Muscle Metastases From Thyroid Carcinoma Evaluated by FDG PET/CT

Li, Zu-Gui; Lin, Zhongqiu; Mu, Hai-Yu

doi:10.1097/md.0000000000002532

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Cassidy et al ( 18 ) reported a case of PTC muscle metastasis; they reported 3 documented cases of symptomatic PTC muscle metastasis, and 3 cases of incidentally diagnosed PTC by single-photon emission computed tomography/CT and PET/CT, from the literature. In 2016, Li et al ( 19 ) discussed a case of synchronous PTC skeletal muscle metastasis and stated that there were ‘only a few reports’ of DTC skeletal muscle metastasis, without precise descriptions. Kuscic et al ( 20 ) published a case of PTC muscle metastasis and undertook a retrospective review of the literature, identifying only 7 reports of PTC muscle metastasis, with reference to studies by Song et al ( 5 ) and Iwai et al ( 21 ).…”

Section: Resultsmentioning

confidence: 99%

Skeletal muscle metastases from papillary and follicular thyroid carcinomas: An extensive review of the literature

Herbowski¹

2018

Oncol Lett

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Skeletal muscle metastasis of papillary or follicular thyroid cancer (PTC/FTC) is a rare finding; only 11 cases of skeletal muscle PTC or FTC metastasis have been included in medical literature reviews. The aim of this study was to identify all published cases of PTC and FTC muscle metastases and derive the true incidence of this malignancy. The probability of detecting the skeletal muscle metastasis of PTC and FTC was calculated based on epidemiological data. Databases of scientific literature on the Internet were searched for articles using relevant key words. The analysis of epidemiological data calculated the probability of detecting skeletal muscle lesions of this type as approximately zero. The literature search revealed 44 published international papers, reporting 58 cases of PTC or FTC skeletal muscle metastasis in 45 patients over 110 years, from 1907 to 2017. The most frequent PTC/FTC metastatic muscle was the gluteus. The majority of cases of muscle metastasis were caused by PTC, and metastatic tumors in the skeletal muscle negatively impacted the survival of patients with PTC or FTC.

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Section: Resultsmentioning

confidence: 99%

Skeletal muscle metastases from papillary and follicular thyroid carcinomas: An extensive review of the literature

Herbowski¹

2018

Oncol Lett

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“…In the present case, the RDM locations included liver, pancreas, kidney, parotid gland, salivary gland, multiple skeletal muscles, and subcutaneous tissues. Generally, locations of simultaneous multiple RDMs do not exceed three (10, 11, 18–23). Interestingly, in the present case, pathologically confirmed RDMs locations from PTC were six.…”

Section: Discussionmentioning

confidence: 99%

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report

Yang

Gong

et al. 2019

Front. Endocrinol.

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Papillary thyroid carcinoma (PTC) commonly metastasizes to regional lymph nodes. However, they infrequently cause rare distant metastases (RDMs), with the exclusion of lungs and bone metastases. RDMs are seldom identified prior to a primary thyroid cancer diagnosis. Therefore, cases initially presenting with synchronously multiple RDMs from PTC are extremely infrequent. This is a rare case of a 48-year-old man with initial diaphragm, pancreatic, and liver tumors from PTC. Following resection of the tumors, an ultrasound-guided fine-needle aspiration (US-FNA) cytology of a mass in the thyroid's left lobe revealed PTC. After postoperative recovery for more than 4 months, physical examination identified an irregular large nodule in the thyroid's isthmus and left lobe, a swollen lymph node in the left neck, and a mass in the right parotid gland. Ultrasound reexamination revealed numerous hypoechoic masses as follows: one in the thyroid's isthmus and entire left lobe (7.3 × 5.9 × 5.1 cm) and multiple in the thyroid's right lobe (0.2–0.3 cm). Ultrasound examination also showed several swollen lymph nodes in the left neck, a mass in the left gluteus maximus, and several masses in both the bilateral parotid and salivary region. The US-FNA's pathological examination confirmed metastatic PTCs in the left gluteus maximus and bilaterally located in the parotid and salivary gland. 18-fluorodeoxyglucose positron-emission tomography and computed tomography scan revealed abnormal uptakes in numerous locations (e.g., the thyroid's isthmus and left lobe, bilateral parotid gland, subcutaneous tissues, etc.). The patient underwent palliative therapy, including total thyroidectomy, bilateral central neck dissection, left lateral neck dissection, and excision of the bilateral parotid and salivary gland. A whole-body scan post-therapeutic radioactive iodine ablation showed exclusive thyroid bed uptake. Subsequently, the patient underwent continuous thyroid stimulating hormone repression therapy and was treated with lenvatinib chemotherapy for ~8 months. The primary thyroid tumor, pancreatic metastasis, and cervical lymph node metastasis were both positive for BRAFV600E and TERT promoter (C288T) mutations. After 13 months of follow-up, the patient is currently in stable clinical conditions. In conclusion, the present case is an extremely rare occurrence of simultaneous multiple RDMs from PTC as the initial presentation.

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“…The other seven cases reported as skeletal muscle metastasis associated with other sites are usually combined with lung metastasis [9,11,13,15]. The most common skeletal metastasis site appears to be the erector spinae [14][15][16]19] and thigh muscle group [10][11][12][13]. Unique cases of muscle metastasis sites were reported localized in trapezoid [17], arm biceps [18], deltoid [7], gastrocnemius [9], and rectus abdominis [20] muscles.…”

Section: The Available Evidence Of the Existing Casesmentioning

confidence: 99%

Skeletal Muscle Metastasis in Papillary Thyroid Microcarcinoma Evaluated by F18-FDG PET/CT

et al. 2020

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Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy and is characterized by slow growth and an indolent biological behavior. Papillary thyroid microcarcinoma is the PTC with the maximum size of the tumor <1cm, considered the most indolent form of thyroid cancer. PTC is usually metastasizes in cervical lymph nodes, lungs and bones and, less commonly, in brain or liver. Skeletal muscle metastases from PTC are extremely rare, a retrospective review of the literature revealed only 13 case reports. Among them, six cases are solitary skeletal muscle metastases, and seven are multiple metastases, most of them being associated with lung lesions. It seems that PTC is prone to metastasizing to the erector spinae and thigh muscles groups with unique cases located in trapezoid, biceps, deltoid, gastrocnemius and rectus abdominis muscles. Although extremely rare, one must bear in mind the fact that muscle metastasis from PTC is possible, and that is the reason we would like to discuss the existing clinical cases and to add a unique case of solitary skeletal muscle metastasis from papillary microcarcinoma.

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Polysplenia Syndrome With Splenic and Skeletal Muscle Metastases From Thyroid Carcinoma Evaluated by FDG PET/CT

Cited by 10 publications

References 33 publications

Skeletal muscle metastases from papillary and follicular thyroid carcinomas: An extensive review of the literature

Skeletal muscle metastases from papillary and follicular thyroid carcinomas: An extensive review of the literature

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report

Skeletal Muscle Metastasis in Papillary Thyroid Microcarcinoma Evaluated by F18-FDG PET/CT

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