Polystyrene Colloids with Surface-Grafted Polyethylene Oxide as Model Systems for Site-Specific Drug Delivery

Brindley, Anne; Davis, S.S.; Davies, Martyn C.; Watts, John F.

doi:10.1006/jcis.1995.1161

Cited by 42 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Watts and coworkers reported the synthesis of copolymer colloids with covalently attached PEO chains via a potassium persulfate-initiated emulsion polymerization of styrene with a PEO-acrylate macromonomer. [16] Wang and Pan synthesized polymer microspheres with surface attached PEO chains via a dispersion copolymerization of styrene with a PEO macromonomer. [17] In addition, Chen and coworkers prepared PS microspheres that are stabilized with PEO macromonomers via a surfactant-free macromonomer/monomer emulsion.…”

Section: Introductionmentioning

confidence: 99%

Facile Access to Hydroxy‐Functional Core–Shell Microspheres via Grafting of Ethylene Oxide by Anionic Ring‐Opening Polymerization

Joso

Reinicke

Walther

et al. 2009

Macromol. Rapid Commun.

View full text Add to dashboard Cite

We present a facile access route to hydroxy-functional narrow disperse microspheres of well-defined grafting density (GD). Ethylene oxide has been grafted from highly crosslinked poly(divinyl benzene) microspheres by anionic ring-opening polymerization using sec-butyllithium as activator together with the phosphazene base t-BuP(4) . Initially, core microspheres have been prepared by precipitation polymerization utilizing divinyl benzene (DVB, 80 wt.-%). The grafting of poly(ethylene oxide) (PEO) from the surface resulted in the formation of functional core-shell microspheres with hydroxy-terminal end groups. The number average particle diameter of the grafted microspheres was 3.6 µm and the particle weight increased by 5.7%. The microspheres were characterized by SEM, FT-IR spectroscopy, elemental analysis, and fluorescence microscopy. The surface GD (determined via two methods) was 1.65 ± 0.06 and 2.09 ± 0.08 chains · nm(-2) , respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Facile Access to Hydroxy‐Functional Core–Shell Microspheres via Grafting of Ethylene Oxide by Anionic Ring‐Opening Polymerization

Joso

Reinicke

Walther

et al. 2009

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14][15][16] PEG macromonomers possessing a hydrophobic spacer in between the PEG chain and the polymerizable double bond was prepared as a monomer with an appreciable surfactant ability for dispersion polymerization. Because most of the PEG macromonomers prepared so far possess no functional group at the distal chain end, the prepared latex lacks functionality on the surface.…”

Section: Resultsmentioning

confidence: 99%

Core–Shell Type Polystyrene Latex Possessing Reactive Poly(ethylene glycol) Brushes on the Surface for High Performance Immunodiagnostics

Ogawa

Nagasaki

Shibata

et al. 2002

Polym J

View full text Add to dashboard Cite

ABSTRACT:Amphiphilic poly(ethylene glycol)-b-polylactide (PEG/PLA) block macromonomers with an aldehyde group at the PEG chain end and a methacryloyl group at the PLA chain end were quantitatively synthesized by anionic polymerization. PEGylated latex particles were then prepared by dispersion radical copolymerization of the PEG/PLA block macromonomer with styrene in water. PEG/PLA macromonomer itself works as a surfactant to stabilize styrene droplets in the copolymerization process. Acetal groups at the PEG chain end on the latex particle were quantitatively converted to aldehyde groups by an acid treatment. In this way, polystyrene latex particles covered with PEG tethered chains possessing an aldehyde end-group were obtained. The size of the latex was quantitatively controlled ranging in size from 56 nm to 235 nm by the amount of the block macromonomer. The number of aldehyde groups on the latex particle was estimated to be approximately 0.029 molecules nm −2 by electric spin resonance (ESR) using 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as a probe. Regardless of the size of the latex particles synthesized in this study, the occupied area of 4-amino-TEMPO on the particle was constant. Biotin was then introduced in a distal end of PEG-strands as a model ligand. The biotin-modified PEGylated latex was coagulated in a facile manner by the addition of avidin. From an inhibitory coagulation test using free biotin, it was found that more than 5.8 × 10 8 times of free biotin was required for the prevention of coagulation. Such a high complex formation ability of the biotin on the latex surface to avidin may be explained by the hypervalency effect. The core-shell type polystyrene latex particles, with reactive PEG brushes thus prepared, show a stable dispersity and a lowered non-specific interaction with proteinous compounds, and may have a promising potential in the diagnostic field.KEY WORDS Polystyrene Latex / Heterobifunctional Block Macromonomer / Aldehyde Group / Ractive Poly(ethylene glycol) Brush / Immunodiagnostic / Latex particles ranging in size from submicron to a few hundred micrometers have been extensively utilized in versatile fields such as paints, inks, adhesives and rubber. The method for controlling size and the size distribution of latex particles has been well established. 1 In 1956, Singer and Plotz reported that polystyrene latex particles adsorbed with immuno gamma globulin G (IgG) can be utilized in immuno diagnostics, 2 because the immuno-coagulation response was enhanced by the use of an IgG adsorbed latex particle. Since then, such a latex-based immunodiagnostic system has been widely utilized and is known as a turbidimetric assay method.When polystyrene-based latex is used in the immunodiagnostic field, non-specific adsorption of protein and cellular components to the latex surface is one of the major obstacles because of its hydrophobic propen- † To whom correspondence should be addressed. sity. Ito et al. reported that dispersion polymerization of styrene in the presence o...

show abstract

“…The zeta potentials of the dialyzed PS and PS-PEO2000 colloids, as a function of pH, are displayed in Figure 4. While an increase in pH gives rise to very little change in zeta potential, a significant difference in the ZP-pH profile was obtained for the copolymer colloids (Brindley et al 1995). (Regazzoni et al 1983).…”

Section: Surface Chargementioning

confidence: 95%

“…PEG chains on the particles extend from the particle surface toward the bulk water (Yoshioka 1991). Brindley et al (1995) prepared a range of polystyrene (PS) colloids with covalently attached polyethylene oxide (PEO) (PEG=2 kDa, or PEO2000) chains. The zeta potentials of the dialyzed PS and PS-PEO2000 colloids, as a function of pH, are displayed in Figure 4.…”

Section: Surface Chargementioning

confidence: 99%

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Kamiński¹,

Ghebremeskel²,

Núñez³

et al. 2004

View full text Add to dashboard Cite

Polystyrene Colloids with Surface-Grafted Polyethylene Oxide as Model Systems for Site-Specific Drug Delivery

Cited by 42 publications

References 0 publications

Facile Access to Hydroxy‐Functional Core–Shell Microspheres via Grafting of Ethylene Oxide by Anionic Ring‐Opening Polymerization

Facile Access to Hydroxy‐Functional Core–Shell Microspheres via Grafting of Ethylene Oxide by Anionic Ring‐Opening Polymerization

Core–Shell Type Polystyrene Latex Possessing Reactive Poly(ethylene glycol) Brushes on the Surface for High Performance Immunodiagnostics

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Contact Info

Product

Resources

About