Polyunsaturated fat in the diet may improve intestinal function in patients with Crohn's disease

French, Margaret A; Parrott, A.; Kielo, E S; Rajotte, Ray V.; Wang, Lawrence C.H.; Thomson, A. B. R.; Clandinin, Michael T.

doi:10.1016/s0925-4439(97)00012-4

Cited by 15 publications

(7 citation statements)

References 33 publications

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“…These results were obtained by inducing enterocyte hyperplasia, which markedly increases the mucosal surface area with a corresponding increase in enteral absorption (Vanderhoof et al 1994). Furthermore, it has been shown recently that increasing dietary PUFA intake in patients with IBD may enhance (by 65%) the absorption and the utilisation of saturated fatty acids such as palmitic acid, improving the overall nutritional status (French et al 1997).…”

Section: Crohn's Disease and Ulcerative Colitis N-3 Polyunsaturated Fmentioning

confidence: 99%

n-3 Fatty acids for the treatment of inflammatory bowel diseases

Belluzzi¹

2002

Proc. Nutr. Soc.

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The aim of the present paper is to briefly review the literature relating to clinical studies of the use of polyunsaturated long-chain fatty acids in the treatment of inflammatory bowel diseases ( IBD) such as ulcerative colitis and Crohn's disease. The reasons for the discrepancies in the findings could be related to the different study designs, different treatments, overlapping of treatment effects, as well as the variety of treatment formulations and doses used, which have led to results that are, in certain instances, very difficult to explain. Emphasis on a treatment formulation which reduces the incidence of side effects, together with careful selection of patients and experimental design, seems to be associated with benefits, and these studies point to the therapeutic potential for these lipids in the therapy of IBD. It is possible that these fatty acids act by reducing low-grade active inflammation rather than by preventing reinitiation of the inflammatory process from a truly quiescent state. Whether this treatment is applicable to all IBD patients has not been fully elucidated. Nevertheless, taken together, all these studies suggest the effectiveness of these new therapeutic approaches, not only when conventional treatment fails or when it is not possible to treat chronically, but also, in some instances, as first choice.

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Section: Crohn's Disease and Ulcerative Colitis N-3 Polyunsaturated Fmentioning

confidence: 99%

n-3 Fatty acids for the treatment of inflammatory bowel diseases

Belluzzi¹

2002

Proc. Nutr. Soc.

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“…A high fat intake has been reported to be associated with an increased risk of ulcerative colitis (UC), and this risk is particularly high in the case of animal fat and cholesterol. 6,12 Among the various unsaturated fatty acids, many studies have shown that -3 polyunsaturated fatty acids have a better effect than that of -6 polyunsaturated fatty acids. 7,8,[13][14][15][16] However, the effects of specific forms of dietary fat on IBD remain controversial.…”

mentioning

confidence: 99%

Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts

Matsunaga

Hokari

Kurihara

et al. 2008

Inflammatory Bowel Diseases

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“…While, there has been also a study which claimed that the high MUFA diets might negatively affect gut microbiota composition 13 . The beneficial effects of diets rich in ω3 fatty acids for improving the intestine function have been also widely reported 17‐19 …”

Section: Introductionmentioning

confidence: 99%

Different typical dietary lipid consumption affects the bile acid metabolism and the gut microbiota structure: an animal trial using Sprague‐Dawley rats

Ye¹,

Liu²

2021

J Sci Food Agric

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BACKGROUND The palm oil (PO), leaf lard oil (LO), rapeseed oil (RO), sunflower oil (SO) and linseed oil (LN) are five of the most typical dietary lipids in most Asian countries. However, their influences on gut health, and the connections between the fatty acid composition, the gut microbiota, and the bile acid metabolism are not fully understood. RESULTS In the present study, results showed that compared with polyunsaturated fatty acid (PUFA)‐rich SO and LN, the saturated fatty acid (SFA)‐rich and monounsaturated fatty acid (MUFA)‐rich PO, LO and RO were more likely to decrease the re‐absorption of bile acid in the colon, which was probably caused by their different role in modulating the gut microbiota structure. LO consumption significantly up‐regulated the Cyp27a1, FXR and TGR5 gene expression level (P < 0.05). The correlation results suggested that the C18:0 was significantly positive correlated with these three genes, indicating that intake of SFA‐rich dietary lipids, especially for the C18:0, could specifically increase the bile acid production by stimulating the bile acid alternative synthesis pathway. Although the bile acid receptor expression in the colon was increased, the re‐absorption of bile acid did not show a significant increase (P > 0.05) as compared with other dietary lipids. Moreover, the C18:2‐rich SO maintained the bile acid metabolic balance probably by decreasing the Romboutsia, while increasing the Bifidobacterium abundance in the colon. CONCLUSIONS The different dietary lipids showed different effects on the bile acid metabolism, which was probably connected with the alterations in the gut microbiota structure. The present study could provide basic understandings about the influences of the different dietary lipids consumption on gut homeostasis and bile acid metabolism. © 2021 Society of Chemical Industry.

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Polyunsaturated fat in the diet may improve intestinal function in patients with Crohn's disease

Cited by 15 publications

References 33 publications

n-3 Fatty acids for the treatment of inflammatory bowel diseases

n-3 Fatty acids for the treatment of inflammatory bowel diseases

Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts

Different typical dietary lipid consumption affects the bile acid metabolism and the gut microbiota structure: an animal trial using Sprague‐Dawley rats

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