Polyvinylpyrrolidone–drug conjugate: synthesis and release mechanism

D'Souza, Ajit Joseph M.; Schowen, Richard L.; Topp, Elizabeth M.

doi:10.1016/j.jconrel.2003.09.014

Cited by 119 publications

(74 citation statements)

References 23 publications

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“…Several synthetic and natural polymers have been employed to modify the surface of the MNPs. These polymers include dextran [7] poly(ethylene glycol)s (PEG) [8], poly(vinylpyrrolidone) (PVP) [9] and chitosan [10] all of which are known to be biocompatible and result in a long blood-circulating MNPs. The PEG, because of its hydrophilicity, nontoxicity and absence of antigenicity and immunogenicity, can be selected to be attached to surface magnetic iron oxide nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Khoee

Kavand

2014

J Nanostruct Chem

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Magnetic iron oxide nanoparticles (MNPs) have been widely explored for use in biomedical applications. In the present study, iron oxide nanoparticles were connected to methoxy poly(ethylene glycol) (mPEG) via a new method. The mPEG was acrylated at first and Michael reaction was carried out between acrylated mPEG and 3-aminopropyl triethoxysilane as a coupling agent. The chemical structures of modified mPEG were characterized by Fourier transform-infrared spectroscopy (FT-IR) and nuclear magnetic resonance. In the next step, iron oxide nanoparticle was coupled with the above-mentioned adduct. Preparation of magnetic nanoparticles with average particle size of 20-30 nm was proved by scanning electron microscopy. The structure of mPEG grafted on the surface of MNPs was confirmed by FT-IR spectroscopy and thermal gravimetric analysis. The synthesized nanoparticles have the potential to be used in different biomedical applications.

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Section: Introductionmentioning

confidence: 99%

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Khoee

Kavand

2014

J Nanostruct Chem

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“…These polymers include dextran 8,9) , poly(ethylene glycol) (PEG) [10][11][12][13][14][15] , and poly(vinylpyrrolidone) (PVP). 16) In particular, PEG exhibits great predominance with improved biocompatibility, biodegradability and blood circulation times.…”

Section: Introductionmentioning

confidence: 99%

Magnetorheological Behavior of Polyethyene Glycol-Coated Fe3O4 Ferrofluids

Qiao

Bai

Tao

et al. 2010

J. Soc. Rheol., Jpn

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Polyethyene glycol (PEG)-coated Fe 3 O 4 ferrofluids were prepared by suspending the PEG-coated Fe 3 O 4 nanoparticles in an oligomeric PEG-400 carrier liquid, and their magnetorheological steady flow behavior was investigated. The PEG modification did not change the crystalline structure of Fe 3 O 4 , and the PEG-coated Fe 3 O 4 nanoparticles were of nearly spherical shape and had a narrow size distribution (4±1 nm in diameter). These nanoparticles exhibited no significant aggregation in the absence of the magnetic field. Under the magnetic field, the nanoparticles aggregated into string-like clusters oriented in the direction of the field. Correspondingly, the ferrofluids behaved essentially as the Newtonian fluids in the absence of the magnetic field but exhibited, under the magnetic field, a magnetorheological effect, i.e., the increase of the shear stress/viscosity associated with a pseudo-plastic and thinning character with no real yield stress. This lack of the real yield stress, possibly reflecting the absence of huge clusters connecting the measuring parts (plates) in the rheometer, suggested that the magnetorheological effect of the ferrofluids were related to deformation/disruption of the magnetically formed clusters of finite sizes under the shear. Interestingly, this effect was most significant for the Fe 3 O 4 nanoparticles having an intermediate amount of PEG coating. This result suggested a possibility that the relaxation of PEG chains in the coating layers of nanoparticles in the clusters contributed to the magnetorheological effect.

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“…Among the widely used hydrophilic polymers, poly-(N-vinyl-2-pyrrolidone) (PVP) is a highly investigated, water-soluble, uncharged, and non-toxic macromolecule with various applications, [6,7] which include pharmaceutical use in drug-delivery systems. [8][9][10][11] Because of its high hydrophilicity, PVP exhibits no LCST up to 100 8C. However, in an aqueous 1.5 M KF, solution PVP shows an LCST behavior at 30 8C.…”

Section: Introductionmentioning

confidence: 99%

3‐Ethylated N‐Vinyl‐2‐pyrrolidone with LCST Properties in Water

Trellenkamp

Ritter

2009

Macromol. Rapid Commun.

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The monomer 3-ethyl-1-vinyl-2-pyrrolidone (3) and the homopolymer poly(3-ethyl-1-vinyl-2-pyrrolidone) (5) have been synthesized. Polymer 5 is soluble in water and shows a critical temperature (T(c) ) of 27 °C. The presence of cyclodextrin causes a slight shift of the T(c) . The lower critical solution temperature (LCST) could be varied between 27 and 40 °C by copolymerization with N-vinyl-2-pyrrolidone. A linear correlation between the T(c) and the copolymer composition is observed.

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Polyvinylpyrrolidone–drug conjugate: synthesis and release mechanism

Cited by 119 publications

References 23 publications

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Magnetorheological Behavior of Polyethyene Glycol-Coated Fe3O4 Ferrofluids

3‐Ethylated N‐Vinyl‐2‐pyrrolidone with LCST Properties in Water

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