Pomegranate as a promising opportunity in medicine and nanotechnology

Karimi, Mahsan; Sadeghi, Rohollah; Kokini, Jozef L.

doi:10.1016/j.tifs.2017.08.019

Cited by 118 publications

(81 citation statements)

References 182 publications

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“…These compounds have been described comprehensively in one of our previous report (Singh et al ., ). Therefore, PoP should be considered as a co‐product with juice extraction and not a waste (Karimi et al ., ).…”

Section: Valorisation Of Pomegranate Peelsmentioning

confidence: 97%

Antimicrobial potential of pomegranate peel: a review

Singh

Kaur

et al. 2018

Int J of Food Sci Tech

107

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Pomegranate peel (PoP) is a byproduct of the fruit juice processing industry, comprising nearly 30-40% of fruit portion. PoP is rich in polyphenols (phenolic acids, tannins and flavonoids particularly anthocyanins) which are known to have diverse biological functions including effectiveness against pathogenic microorganisms. PoP has shown a broad spectrum antimicrobial activity (AMA) of PoP against both Gram-positive and Gram-negative bacteria. It also presented promising AMA against antibiotic resistant microbial strains such as methicillin-resistant Staphylococcus aureus. The high levels of polyphenols, particularly punicalagin and ellagic acid, present in PoP have been responsible for its antifungal properties. PoP is effective against many fungi including both pathogenic (Aspergillus flavus) and opportunistic pathogens. These activities of PoP may be exploited as a phytomedicine for humans, in order to eliminate the use of antibiotics and reducing their cost. This review provides collective up-to-date information on the efficacy of plant-derived AMA of PoP.Pomegranate peel antimicrobial activity B. Singh et al. 960

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Section: Valorisation Of Pomegranate Peelsmentioning

confidence: 97%

Antimicrobial potential of pomegranate peel: a review

Singh

Kaur

et al. 2018

Int J of Food Sci Tech

107

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“…It is defined as the control of matter at the atomic and molecular levels (Kargozar & Mozafari, ). Some fields where nanotechnology has been applied are the food industry, (Karimi, Sadeghi, & Kokini, ), food safety (Krishna et al., ), the cosmeceutical industry (Kaul, Gulati, Verma, Mukherjee, & Nagaich, ), water treatment (Mauter et al., ), and health (Tapia‐Hernández et al., ). Within nanotechnology, nanoencapsulation is a strategy in recent years for the protection of food ingredients and nutraceuticals (Assadpour & Jafari ; Liang et al., ).…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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“…Finding effective bioactive compounds and phytochemicals derived from fruits and plants that provide health benefits at a reduced cost has become important. 2 Hyperglycemia associated with diabetes mellitus increases complications and premature death due to constant oxidative stress, so it is the principal dysfunction that has to be treated. Many parts of the pomegranate, like the peel, seeds, flowers, and juice, 3,4 have shown hypoglycemic effects attributed to their phenolic compounds by the suggested effects on the inhibition of enzymes related to carbohydrate metabolism, 5,6 stimulation of insulin release by b-cells, 7 and protection of pancreatic tissue.…”

Section: Introductionmentioning

confidence: 99%

Potential Hypoglycemic Effect of Pomegranate Juice and Its Mechanism of Action: A Systematic Review

Virgen-Carrillo

Moreno

Miramontes

2020

Journal of Medicinal Food

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Pomegranate juice (PJ) has gained popularity attributed to its phenolic compounds and their medicinal properties. Its potential hypoglycemic effect has been related to enzymatic inhibition, insulin release, and the protection of pancreatic tissue. These effects depend on several aspects, such as the content and composition of phenols in pomegranate and characteristics of the organism that consumes the juice. The objective of this study was to systematically review scientific evidence investigating the hypoglycemic effect of PJ; the factors that affect bioactive compounds; and the mechanisms of action attributed to this effect. Human and rodent in vivo and in vitro studies were retrieved from PubMed, Scopus, and ScienceDirect databases. After reviewing the articles, it was identified that the methodologies and results among the scientific evidence were quite heterogeneous. Despite these limitations, many of the in vivo and in vitro studies found important hypoglycemic effects from PJ, as well as an increase in the function of b-cell, insulin secretion, a significantly lower activity of a-amylase enzyme, an inhibition of the enzyme a-glucosidase and dipeptidyl peptidase-4 (DPP-4), and the protection against DNA damage. Determining the potential health benefits of polyphenols contained in the pomegranate is limited for multiple factors that could affect the efficacy of PJ. Overall, the results of this review suggest the need for further experimentation, using controlled variable factors and testing the effect of PJ under similar experimental conditions.

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Pomegranate as a promising opportunity in medicine and nanotechnology

Cited by 118 publications

References 182 publications

Antimicrobial potential of pomegranate peel: a review

Antimicrobial potential of pomegranate peel: a review

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Potential Hypoglycemic Effect of Pomegranate Juice and Its Mechanism of Action: A Systematic Review

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