Pomegranate-inspired multifunctional nanocomposite wound dressing for intelligent self-monitoring and promoting diabetic wound healing

Wang, Ze; Ou, Xiaolan; Guan, Lin; Li, Xingchen; Liu, Annan; Li, Lei; Zvyagin, Andrei V.; Qu, Wenrui; Yang, Mingxi; Lin, Quan

doi:10.1016/j.bios.2023.115386

Cited by 28 publications

(10 citation statements)

References 19 publications

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“…Thanks to the development of disciplines such as optics and microelectronics, some smart hydrogels that can directly monitor the status of wounds have emerged. 102 Here, we classify them into single-detection smart hydrogels and multidetection smart hydrogels based on the number of detection targets.…”

Section: Smart Hydrogels For Wound Monitoringmentioning

confidence: 99%

Recent advances of hydrogels as smart dressings for diabetic wounds

Wang,

Yang,

Zhao

et al. 2024

J. Mater. Chem. B

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Section: Smart Hydrogels For Wound Monitoringmentioning

confidence: 99%

Recent advances of hydrogels as smart dressings for diabetic wounds

Wang,

Yang,

Zhao

et al. 2024

J. Mater. Chem. B

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“…Reactive oxygen therapy has emerged clinically, which focuses on the use of enzymes to catalyze the production of hydroxyl free radicals, superoxide, and other reactive oxygen species from hydrogen peroxide (H 2 O 2 ) to combat bacteria. − Although many proteases, such as the natural peroxidases and oxidases, are used to catalyze the production of reactive oxygen species, natural proteases suffer from denaturation and loss of enzymatic activity due to their ease of digestion. As a result, researches have focused on nanoparticles (NPs) known as nanoenzymes, which have catalytic properties comparable to those of natural proteases. − Metal and metal oxides, in particular, are especially promising for biomedical applications due to their superior catalytic capabilities and innate antibacterial activity. − For example, Wang et al investigated the effect of ultrasmall Au/Pt NCs@GO X clusterzyme on enhancing cascade catalyzed antibiofilm resistance . Yang et al found that hollow Cu 2 MoS 4 nanospheres could be used to treat implant infections and achieve immuomodulation .…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy

Wu,

Xiang,

Zhang

et al. 2024

Langmuir

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Wounds caused by bacterial infections have become a major challenge in the medical field; however, the overuse of antibiotics has led to increased resistance and bioaccumulation. Therefore, it is urgent to develop an antibacterial agent with excellent antibacterial properties and biosafety. Here, we designed an antibacterial platform that combines photothermal and chemical kinetics therapies. Platinum−cobalt (PtCo) bimetallic nanoparticles (NPs) were first prepared, and then PtCo@MnO 2 nanoflowers were obtained by adding MES buffer solution and KMnO 4 to the PtCo bimetallic nanoparticle suspension using ultrasound. When light strikes metal NPs, they can strongly absorb the photon energy, resulting in photothermal properties. In addition, Pt and Co were used as the oxidase mimics, and MnO 2 was used as the catalase mimic. In summary, the photothermal capacity of PtCo@MnO 2 nanoflowers with rough surfaces can effectively disrupt the permeability of the bacterial cell membranes. Further, by catalyzing H 2 O 2 , PtCo@MnO 2 nanoflowers can generate large amounts of hydroxyl free radicals, which can damage bacterial cell membranes, proteins, and DNA. In addition, MnO 2 can effectively alleviate the hypoxic environment of the bacterially infected areas and activate deep bacteria, thus achieving the goal of complete sterilization. The in vitro and in vivo results showed that PtCo@MnO 2 displayed excellent antibacterial properties and good biocompatibility.

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“…Recently, nanomaterials have demonstrated significant advantages in the biomedical field, particularly in the diagnosis and improved RT of tumors. Notably, gold nanoparticles (AuNPs) have attracted great attention owing to ultrasmall size, easy surface functionalization, and great biocompatibility. , As high-Z nanomaterials, AuNPs possess strong radiation attenuation abilities and could function as a radiosensitizer to enhance RT. , Furthermore, AuNPs have distinctive optical property and X-ray attenuation ability, endowing them with excellent FL and CT imaging capabilities. , In addition, researchers have found that nanozymes (a type of nanomaterial with enzyme-like activities) involving transition metal ions (such as Fe 2+ and Cu + ) induce ferroptosis in tumor cells by Fenton or Fenton-like reaction. , Chemodynamic therapy (CDT) based on Fenton reaction is a promising nanocatalytic approach, which has attracted increasing attention. It involves the use of excess endogenous H 2 O 2 produced in cancer cells to produce ROS that destroy biological molecules of cancer cells, resulting in tumor-specific treatment, with negligible damage to normal tissues. , Copper (Cu)-based nanocatalysts have shown tremendous potential in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Amplifier for Apoptosis-Ferroptosis Mediated High-Efficiency Radiosensitization of Tumors

Wang,

Ren,

et al. 2024

ACS Nano

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Insufficient reactive oxygen species (ROS) production and radioresistance have consistently contributed to the failure of radiotherapy (RT). The development of a biomaterial capable of activating ROS-induced apoptosis and ferroptosis is a potential strategy to enhance RT sensitivity. To achieve precision and high-efficiency RT, the theranostic nanoplatform Au/Cu nanodots (Au/CuNDs) were designed for dual-mode imaging, amplifying ROS generation, and inducing apoptosis-ferroptosis to sensitize RT. A large amount of ROS is derived from three aspects:(1) When exposed to ionizing radiation, Au/CuNDs effectively absorb photons and emit various electrons, which can interact with water to produce ROS. (2) Au/CuNDs act as a catalase-like to produce abundant ROS through Fenton reaction with hydrogen peroxide overexpressed of tumor cells. (3) Au/CuNDs deplete overexpressed glutathione, which causes the accumulation of ROS. Large amounts of ROS and ionizing radiation further lead to apoptosis by increasing DNA damage, and ferroptosis by enhancing lipid peroxidation, significantly improving the therapeutic efficiency of RT. Furthermore, Au/CuNDs serve as an excellent nanoprobe for high-resolution near-infrared fluorescence imaging and computed tomography of tumors. The promising dual-mode imaging performance shows their potential application in clinical cancer detection and imaging-guided precision RT, minimizing damage to adjacent normal tissues during RT. In summary, our developed theranostic nanoplatform integrates dual-mode imaging and sensitizes RT via ROS-activated apoptosis-ferroptosis, offering a promising prospect for clinical cancer diagnosis and treatment.

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Pomegranate-inspired multifunctional nanocomposite wound dressing for intelligent self-monitoring and promoting diabetic wound healing

Cited by 28 publications

References 19 publications

Recent advances of hydrogels as smart dressings for diabetic wounds

Recent advances of hydrogels as smart dressings for diabetic wounds

Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy

Reactive Oxygen Species Amplifier for Apoptosis-Ferroptosis Mediated High-Efficiency Radiosensitization of Tumors

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