Pomegranate Juice Is Potentially Better Than Orange Juice in Improving Antioxidant Function in Elderly Subjects

Parashar, Amit

doi:10.9734/ijbcrr/2011/164

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…Pomegranate, an ET‐rich fruit crop, is a widely used source of dietary polyphenols. An analysis of the antioxidant activity of various dietary supplements has shown that the antioxidant activity of pomegranate juice exceeds that of orange juice (Parashar, ), milk thistle, green tea, grape seed, goji, acai (Henning et al ., ) and infusions of red wine or green tea (Gil et al ., ). In addition to antioxidant function, EA and punicalagins in pomegranate have been implicated as potent anticancer and antiatherosclerotic agents (Adams et al ., ; Viuda‐Martos et al ., ; Usta et al ., ).…”

Section: Discussionmentioning

confidence: 99%

The pomegranate (Punica granatum L.) genome and the genomics of punicalagin biosynthesis

et al. 2017

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Pomegranate (Punica granatum L.) is a perennial fruit crop grown since ancient times that has been planted worldwide and is known for its functional metabolites, particularly punicalagins. We have sequenced and assembled the pomegranate genome with 328 Mb anchored into nine pseudo-chromosomes and annotated 29 229 gene models. A Myrtales lineage-specific whole-genome duplication event was detected that occurred in the common ancestor before the divergence of pomegranate and Eucalyptus. Repetitive sequences accounted for 46.1% of the assembled genome. We found that the integument development gene INNER NO OUTER (INO) was under positive selection and potentially contributed to the development of the fleshy outer layer of the seed coat, an edible part of pomegranate fruit. The genes encoding the enzymes for synthesis and degradation of lignin, hemicelluloses and cellulose were also differentially expressed between soft- and hard-seeded varieties, reflecting differences in their accumulation in cultivars differing in seed hardness. Candidate genes for punicalagin biosynthesis were identified and their expression patterns indicated that gallic acid synthesis in tissues could follow different biochemical pathways. The genome sequence of pomegranate provides a valuable resource for the dissection of many biological and biochemical traits and also provides important insights for the acceleration of breeding. Elucidation of the biochemical pathway(s) involved in punicalagin biosynthesis could assist breeding efforts to increase production of this bioactive compound.

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Section: Discussionmentioning

confidence: 99%

The pomegranate (Punica granatum L.) genome and the genomics of punicalagin biosynthesis

et al. 2017

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“…EA, on the other hand, restored cognitive performance related to mild age-related declines in overweight participants aged around 50 years after 12 weeks EA treatment course [16]. Supplementation with EA-rich foods and beverages as pomegranate juice has been shown to improve the antioxidant status in aged healthy humans (aged over 60 years) after four weeks of treatment [17,18]. LA and EA derivatives and some supplements representing a rich source of both have been tested on humans, and have improved some symptoms that also occur in PD.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson’s Disease: A Comparative Study

et al. 2020

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We compared the neuroprotective action of three natural bio-antioxidants (AOs): ellagic acid (EA), α-lipoic acid (LA), and myrtenal (Myrt) in an experimental model of Parkinson’s disease (PD) that was induced in male Wistar rats through an intrastriatal injection of 6-hydroxydopamine (6-OHDA). The animals were divided into five groups: the sham-operated (SO) control group; striatal 6-OHDA-lesioned control group; and three groups of 6-OHDA-lesioned rats pre-treated for five days with EA, LA, and Myrt (50 mg/kg; intraperitoneally- i.p.), respectively. On the 2nd and the 3rd week post lesion, the animals were subjected to several behavioral tests: apomorphine-induced rotation; rotarod; and the passive avoidance test. Biochemical evaluation included assessment of main oxidative stress parameters as well as dopamine (DA) levels in brain homogenates. The results showed that all three test compounds improved learning and memory performance as well as neuromuscular coordination. Biochemical assays showed that all three compounds substantially decreased lipid peroxidation (LPO) levels, and restored catalase (CAT) activity and DA levels that were impaired by the challenge with 6-OHDA. Based on these results, we can conclude that the studied AOs demonstrate properties that are consistent with significant antiparkinsonian effects. The most powerful neuroprotective effect was observed with Myrt, and this work represents the first demonstration of its anti-Parkinsonian impact.

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“…The 28 studies ( n = 1089) included evaluated the effects of consumption of fruit or vegetable juices on healthy people or patients who had chronic diseases or a debilitating condition (e.g., diabetes, cancer, hemodialysis) [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38]. Most studies (75%) utilized a parallel design and 17 of them used a placebo juice (mainly composed by flavored water and sucralose) for comparison.…”

Section: Resultsmentioning

confidence: 99%

Impact of Natural Juice Consumption on Plasma Antioxidant Status: A Systematic Review and Meta-Analysis

et al. 2015

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Abstract:Background: Oxidative stress may lead to overproduction of reactive species and a decrease in antioxidant defenses, resulting in chronic diseases such as diabetes and cancer. The consumption of natural compounds with an antioxidant profile may be a preventive alternative. Therefore, we aimed to obtain evidence regarding the potential antioxidant activity of juices in human plasma. Methods: A systematic review and meta-analysis was performed, which included randomized controlled trials that compared the use of fruit or vegetable juices vs. placebo or other beverages. An electronic search was conducted in PubMed, Scopus, International Pharmaceutical Abstracts, and SciELO. The outcome measures extracted were related to antioxidant status, e.g., vitamin C, superoxide dismutase (SOD), and catalase (CAT) levels and reduction in malondialdehyde (MDA) and antioxidant capacity measured as TEAC. Results: Twenty-eight trials were identified (n = 1089), of which 16 were used for meta-analysis. No significant differences were observed between juices and placebo with regard to TEAC, SOD, and CAT. However, juices were superior to control in enhancing vitamin C and reducing MDA. Conclusions: Natural juices are possible candidates for the management of oxidative stress. The effects of juices should be further investigated by conducting larger and well-defined trials of longer duration.

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Pomegranate Juice Is Potentially Better Than Orange Juice in Improving Antioxidant Function in Elderly Subjects

Cited by 9 publications

References 27 publications

The pomegranate (Punica granatum L.) genome and the genomics of punicalagin biosynthesis

The pomegranate (Punica granatum L.) genome and the genomics of punicalagin biosynthesis

Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson’s Disease: A Comparative Study

Impact of Natural Juice Consumption on Plasma Antioxidant Status: A Systematic Review and Meta-Analysis

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