No abstract

The diversity of signalling opportunities within microbial communities, and the significant role of these molecules in coordinating gene expression and promoting biofilm formation, has provided the impetus to investigate the potential of inhibitory analogues to disrupt these networks, thereby providing mechanisms to control or influence the development of dental plaque. Within the oral biofilms, resident bacterial cells interact with one another and exchange messages in the form of signalling molecules and metabolites. In this review article, our aim is to elaborate the role of this quorum sensing and their involvement in pathogenesis to decipher information that can be useful to target pathways to control diseases.

In the present study, 26 elderly subjects were recruited and randomly divided into 2 groups, that is, orange (low in antioxidant capacity) and pomegranate (high in antioxidant capacity) groups, and 250 mL of juice was consumed daily for 4 weeks. Changes in plasma antioxidant capacity, activity of antioxidant enzymes, contents of ascorbic acid, vitamin E, reduced glutathione, malondialdehyde, oxidized low-density lipoprotein and carbonyls, and the degree of DNA damage in mononuclear blood cells were measured. Urine samples were collected for determination of 8hydroxy-2′-deoxyguanosine content. Increased plasma antioxidant capacity and decreased plasma carbonyl content were demonstrated after daily consumption of pomegranate juice. In comparison, orange juice consumption presented a less significant effect on antioxidant function in elderly subjects. It is concluded that daily consumption of pomegranate juices is potentially better than orange juice in improving antioxidant function in the elderly. Because the plasma ascorbic acid, vitamin E, and reduced glutathione contents did not differ significantly between the 2 groups in this study, the phenolics may be the functional components contained in pomegranate juice that accounted for the observations.

Periodontal diseases have alarmed the current scenario globally. Still very less evidences has been clued in this area. Previously it was thought that virus is not involved with severe cases of periodontitis. In 20th century, virus association of periodontal cases has shown for the first time. After that several studies covered the strong evidences about direct virus isolation from deep focal sites. The articles published recently in journals of repute has shown a very strong evidences in the involvement of human herpes virus, Epstein Barr virus, Human cytomegalovirus, Human Immunodeficiency Virus in both chronic as well aggressive periodontitis. Our main aim of this review is to have compiled information in this article for what have been done in the area and remaining futuristic approach; as a current concern. This will not only help in early diagnostic and virus characterization as well identification of biomarkers for disease. The compiled information and critical aspects in the area will also help to develop suitable diagnostics and therapeutics.These uncertainties have given targeted efforts to find viral etiologic factors for periodontitis.

No abstract